Protein detail

SYNPO

Synaptopodin

Entry name SYNPO	UniProt ID Q8N3V7	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Synaptopodin

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000171992

Entrez Gene Symbol

SYNPO

Gene Synonym

KIAA1029

Gene Description

Synaptopodin

Chromosome

Position

150601080-150659207

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization6

Tissue SpecificbrainCell SpecificBrain excitatory neuronsSingle-Nuclei Brain Specificthalamic excitatorySecretome LocationIntracellular and membraneSecretome FunctionReceptor

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (11)

Page 1 of 2

Molecular Function (2)

Biological Process (3)

KEGG

hsa04530 Tight junction

Mediation Categories

Fusion and delivery mediation

Relations & Evidence8

Ligand-Receptor Signaling (7)

7 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
tight_junction	tight_junction	GO_Intercell	Yes	Yes	No	No	No
tight_junction	tight_junction	OmniPath	Yes	Yes	No	No	No

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	4	40596376 38576002 39996590 36573687

Sequence, Structure & Domains10

Sequences

Length

929

Mass

99,463

Sequence

MLGPHLPPPPLAPSEGRPTPCAFQIPDGSYRCLALEAEESSGEEGLQGEVGPTDLEEDEGVSRSGDDSACRVTQGTPQLPKALGIQPPSCSREEQGASQHDDRASQDWDVVKAGQMMTASPSPGPGPRVAQKPALGRSTSLTEKDLKEAKARSQQIAAQLTTPPSSNSRGVQLFNRRRQRVNEFTLESHGQRGQKPSQESLRVLPSSLPGHAPGLSLSSTSLPEPGPPRHPSPQSPDRGVPGHSMEGYSEEASLLRHLEKVASEEEEVPLVVYLKENAALLTANGLHLSQNREAQQSSPAPPPAEVHSPAADVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSLPLSSIQQNSSEAQLPSNGTGPASKPSTLCADGQPQAPAEEVRCSTLLIDKVSTPATTTSTFSREATLIPSSRPPASDFMSSSLLIDIQPNTLVVSADQEMSGRAAATTPTKVYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRPLGNFTAPPTYTETLSTAPLASWVRSPPSYSVLYPSSDPKSSHLKGQAVPASKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDQGEVGVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTPPASLYHGYLPENGVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNLPKGALPPSPALPRPSRSSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQVWKPSFCFK

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8N3V7-1; Sequence=Displayed; Name=2; IsoId=Q8N3V7-2; Sequence=VSP_010476, VSP_010477; Name=3; IsoId=Q8N3V7-3; Sequence=VSP_010476

Alternative Sequence

1..244; Missing (in isoform 2 and isoform 3); 921..929; VWKPSFCFK -> DRRESLPTSPPWTPGASRPPSSLDGWVSPGPWEPGRGSSMSSPPPLPPPPPMSPSWSERSVSPLRPETEARPPSRQLQALLARNIINAARRKSASPRSAGAENPRPFSPPRAPPPPPPPPPPPPRMRSPQPARPGSAAVPGAAFAPIPRSPLPAGPSSCTSPRSPLPAPPRPFLYRRSPTDSDVSLDSEDSGAKSPGILGYNICPRGWNGSLRLKRGSLPAEASCTT (in isoform 2)

Domain & Motif Annotations

Compositional Bias

1..12; Pro residues; 60..69; Basic and acidic residues; 91..110; Basic and acidic residues; 142..151; Basic and acidic residues; 152..170; Polar residues; 224..234; Pro residues; 317..332; Low complexity; 333..379; Polar residues; 646..656; Basic and acidic residues; 685..698; Low complexity; 826..839; Low complexity; 866..880; Polar residues

Motif

562..565; PPxY motif; 581..584; PPxY motif

Region

1..260; Disordered; 285..389; Disordered; 509..558; Disordered; 589..610; Disordered; 630..726; Disordered; 740..763; Disordered; 826..916; Disordered

Protein Families

Synaptopodin family

Sequence Similarities

Belongs to the synaptopodin family.

Clinical Relevance4

Antibody (4)

CAB033265 HPA034631 CAB037325 HPA071347

Interaction Protein

ENSG00000072110

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications1

PMID	Title	Abstract
35029059	Human neural cell type-specific extracellular vesicle proteome defines disease-related molecules associated with activated astrocytes in Alzheimer's disease brain.	No abstract available