Protein detail
FGRL1
Fibroblast growth factor receptor-like 1 (FGF receptor-like protein 1) (FGF homologous factor receptor) (FGFR-like protein) (Fibroblast growth factor receptor 5) (FGFR-5)
Entry name FGRL1 | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification Human disease related genesPredicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information12
Protein Names
Fibroblast growth factor receptor-like 1 (FGF receptor-like protein 1) (FGF homologous factor receptor) (FGFR-like protein) (Fibroblast growth factor receptor 5) (FGFR-5)
Protein Class (4)
Human disease related genesPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function (3)
- Human disease related genes:Other congenital disorders:Chromosomal abnormalities
- Predicted intracellular proteins
- Transporters:Accessory Factors Involved in Transport
Transmembrane
379..399; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Description
Fibroblast growth factor receptor like 1
Chromosome
4
Position
1009936-1026898
Supporting publications (n)
1
EVMP confidence score
0.25
Fluorescence & Localization3
Tissue SpecifickidneyCell SpecificAlveolar cells type 1Single-Nuclei Brain Specificchoroid plexus epithelial cell
Function & Pathway6
Protein Function (3)
- Human disease related genes:Other congenital disorders:Chromosomal abnormalities
- Predicted intracellular proteins
- Transporters:Accessory Factors Involved in Transport
Cellular Component (4)
Molecular Function (4)
Biological Process (3)
Reactome (4)
Mediation Categories (3)
Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence50
Ligand-Receptor Signaling (49)
49 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| growth_factor_fgf_family | receptor | ICELLNET | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | HPMR | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| adhesion | adhesion | HGNC | Yes | Yes | No | Yes | No |
| ig_like | cell_adhesion | HGNC | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | Yes | No |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 15326289 |
Sequence, Structure & Domains6
Sequences
Length
504
Mass
54,537
Sequence
MTPSPLLLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLDDISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEAAEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGPPVASSSSATSLPWPVVIGIPAGAVFILGTLLLWLCQAQKKPCTPAPAPPLPGHRPPGTARDRSGDKDLPSLAALSAGPGVGLCEEHGSPAAPQHLLGPGPVAGPKLYPKLYTDIHTHTHTHSHTHSHVEGKVHQHIHYQC
Domain & Motif Annotations
Compositional Bias
129..144; Polar residues; 407..418; Pro residues; 423..432; Basic and acidic residues
Domain (FT)
29..115; Ig-like C2-type 1; 147..237; Ig-like C2-type 2; 246..354; Ig-like C2-type 3
Region
123..155; Disordered; 407..435; Disordered
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 38409426 | Mass Spectrometry-Based Characterization of Protein Aggregates in Tissues and Biofluids. | The western blotting analyses of the isolated pellet showed the positivity for CD89 and CD63, consolidated markers of exosomes, confirming the presence of exosomes within the pellet but not in the supernatant in human plasma. |