Protein detail

PNKD

Probable thioesterase PNKD (EC 3.1.2.-) (Myofibrillogenesis regulator 1) (MR-1) (Paroxysmal nonkinesiogenic dyskinesia protein) (Trans-activated by hepatitis C virus core protein 2)

Entry name PNKD	UniProt ID Q8N490	EVMP score 0.38
Frequency 2	Transmembrane count	Protein classification

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Probable thioesterase PNKD (EC 3.1.2.-) (Myofibrillogenesis regulator 1) (MR-1) (Paroxysmal nonkinesiogenic dyskinesia protein) (Trans-activated by hepatitis C virus core protein 2)

Protein Function

Predicted intracellular proteins
FDA approved drug targets:Biotech drugs

Ensembl

ENSG00000153029

Entrez Gene Symbol

MR1

Frequency

EVMP Score

0.38

Fluorescence & Localization

Cell SpecificOocytesBlood Cell Specificplasmacytoid DC

Function & Pathway

Protein Function

Predicted intracellular proteins
FDA approved drug targets:Biotech drugs

Cellular Component

Molecular Function

Biological Process

Mediation Categories

Fusion and delivery mediationImmune mediationMetabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

32 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	UniProt_topology	No	No	Yes	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	Yes	Yes	No
transmembrane_predicted	transmembrane	OmniPath	No	No	Yes	Yes	No
transmembrane	transmembrane	GO_Intercell	No	No	Yes	Yes	No
transmembrane	transmembrane	TopDB	No	No	Yes	Yes	No
transmembrane	transmembrane	LOCATE	No	No	Yes	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	Yes	Yes	No
transmembrane	transmembrane	OmniPath	No	No	Yes	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	Yes	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	Yes	Yes	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

31 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
FAM90A1 FAM90A5 KDM5B MTMR14	A8MXJ8 Q86YD7 Q8NCE2 Q9UGL1	0:0:0:0	hu.MAP
CCDC146 CCNA1 CCNA2 CCNB1 CCNB2 CDK1 CDT1 CKS1B CKS2 CREBBP GMNN MCIDAS MTMR1 ORC1 PHF8 PKMYT1 RBL1 RBL2 SCAPER SKP2 TICRR TRIM49	D6RGH6 O75496 O95067 P06493 P0CI25 P14635 P20248 P28749 P33552 P61024 P78396 Q08999 Q13309 Q13415 Q13613 Q7Z2Z1 Q8IYE0 Q92793 Q99640 Q9BY12 Q9H211 Q9UPP1	0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0	hu.MAP2
CCDC146 GMNN MCIDAS MID2 MTMR1	D6RGH6 O75496 Q13613 Q8IYE0 Q9UJV3	0:0:0:0:0	hu.MAP2
FAM90A1 FAM90A26 KDM5B MTMR14	D6RGX4 Q86YD7 Q8NCE2 Q9UGL1	0:0:0:0	hu.MAP
BRD3 BRD4 FAM90A1 KDM5B MTMR14	O60885 Q15059 Q86YD7 Q8NCE2 Q9UGL1	0:0:0:0:0	hu.MAP
FMR1 FXR1 FXR2 TOP3B	O95985 P51114 P51116 Q06787	0:0:0:0	hu.MAP2
DAZL FMR1 FXR1 FXR2 TDRD3 TOP3B	O95985 P51114 P51116 Q06787 Q92904 Q9H7E2	0:0:0:0:0:0	hu.MAP2
FMR1 PUM1 TOP3B	O95985 Q06787 Q14671	0:0:0	hu.MAP2
FMR1 RANBP9 UBC UBE2I	P0CG48 P63279 Q06787 Q96S59	1:1:1:1	CompleatCFinder	Compleat:HC6744
BCLAF1 FMR1 FXR1 MATR3	P43243 P51114 Q06787 Q9NYF8	0:0:0:0	hu.MAP

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	38716512

Sequence, Structure & Domains

Sequences

Length

385

Mass

42,876

Sequence

MAAVVAATALKGRGARNARVLRGILAGATANKASHNRTRALQSHSSPEGKEEPEPLSPELEYIPRKRGKNPMKAVGLAWYSLYTRTWLGYLFYRQQLRRARNRYPKGHSKTQPRLFNGVKVLPIPVLSDNYSYLIIDTQAQLAVAVDPSDPRAVQASIEKEGVTLVAILCTHKHWDHSGGNRDLSRRHRDCRVYGSPQDGIPYLTHPLCHQDVVSVGRLQIRALATPGHTQGHLVYLLDGEPYKGPSCLFSGDLLFLSGCGRTFEGNAETMLSSLDTVLGLGDDTLLWPGHEYAEENLGFAGVVEPENLARERKMQWVQRQRLERKGTCPSTLGEERSYNPFLRTHCLALQEALGPGPGPTGDDDYSRAQLLEELRRLKDMHKSK

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=MR-1L; IsoId=Q8N490-1; Sequence=Displayed; Name=2; Synonyms=MR-1S; IsoId=Q8N490-2; Sequence=VSP_027739, VSP_027740; Name=3; Synonyms=MR-1M; IsoId=Q8N490-3; Sequence=VSP_027736; Name=4; IsoId=Q8N490-4; Sequence=VSP_027737, VSP_027738

Alternative Sequence

1..79; MAAVVAATALKGRGARNARVLRGILAGATANKASHNRTRALQSHSSPEGKEEPEPLSPELEYIPRKRGKNPMKAVGLAW -> MAWQGWPAAWQWVAGCWLLLVLVLVLLVSPRGCRARRGLRGLLMAHSQRLLFRIG (in isoform 3); 1..60; Missing (in isoform 4); 61..78; EYIPRKRGKNPMKAVGLA -> MPSSVHHTKRQMMSIYCY (in isoform 4); 80..142; YSLYTRTWLGYLFYRQQLRRARNRYPKGHSKTQPRLFNGVKVLPIPVLSDNYSYLIIDTQAQL -> AIGFPCGILLFILTKREVDKDRVKQMKARQNMRLSNTGEYESQRFRASSQSAPSPDVGSGVQT (in isoform 2); 143..385; Missing (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Region

32..58; Disordered

Protein Families

Metallo-beta-lactamase superfamily
Glyoxalase II family

Sequence Similarities

Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

Clinical Relevance

Drugs

ANTI-THYMOCYTE GLOBULIN