Protein detail
PNKD
Probable thioesterase PNKD (EC 3.1.2.-) (Myofibrillogenesis regulator 1) (MR-1) (Paroxysmal nonkinesiogenic dyskinesia protein) (Trans-activated by hepatitis C virus core protein 2)
Entry name PNKD | UniProt ID | EVMP score 0.38 |
Frequency 2 | Transmembrane count | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Probable thioesterase PNKD (EC 3.1.2.-) (Myofibrillogenesis regulator 1) (MR-1) (Paroxysmal nonkinesiogenic dyskinesia protein) (Trans-activated by hepatitis C virus core protein 2)
Protein Function
- Predicted intracellular proteins
- FDA approved drug targets:Biotech drugs
Ensembl
Entrez Gene Symbol
Frequency
2
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificOocytesBlood Cell Specificplasmacytoid DC
Function & Pathway
Protein Function
- Predicted intracellular proteins
- FDA approved drug targets:Biotech drugs
Cellular Component
- GO:0000139 Golgi membrane
- GO:0005615 extracellular space
- GO:0005783 endoplasmic reticulum
- GO:0005789 endoplasmic reticulum membrane
- GO:0005886 plasma membrane
- GO:0009897 external side of plasma membrane
- GO:0031901 early endosome membrane
- GO:0031902 late endosome membrane
- GO:0042612 MHC class I protein complex
Molecular Function
Biological Process
Mediation Categories
Fusion and delivery mediationImmune mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
32 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_topology | No | No | Yes | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | Yes | Yes | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | Yes | Yes | No |
| transmembrane | transmembrane | GO_Intercell | No | No | Yes | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | Yes | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | Yes | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | Yes | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | Yes | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | Yes | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | Yes | Yes | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
31 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| FMR1FXR1FXR2 | P51114P51116Q06787 | 0:0:0 | hu.MAP2 | |||
| FMR1FXR1FXR2KBTBD2 | P51114P51116Q06787Q8IY47 | 0:0:0:0 | hu.MAP2 | |||
| FMR1FXR1KBTBD2 | P51114Q06787Q8IY47 | 0:0:0 | hu.MAP | |||
| FMR1KBTBD2 | Q06787Q8IY47 | 0:0 | hu.MAP | |||
| FMR1TDRD3 | Q06787Q9H7E2 | 0:0 | hu.MAP2 | |||
| MTMR1 | Q13613 | 4 | PDB | PDB:5c16 | ||
| MTMR1TRIM10TRIM35TRIM44 | Q13613Q96DX7Q9UDY6Q9UPQ4 | 0:0:0:0 | hu.MAP | |||
| MTMR12MTMR2SBF2 | Q13614Q86WG5Q9C0I1 | 0:0:0 | hu.MAP2 | |||
| MTMR10MTMR12MTMR2SBF2 | Q13614Q86WG5Q9C0I1Q9NXD2 | 0:0:0:0 | hu.MAP | |||
| FAM90A1KDM5BMTMR14 | Q86YD7Q8NCE2Q9UGL1 | 0:0:0 | hu.MAPhu.MAP2 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 38716512 |
Sequence, Structure & Domains
Sequences
Length
385
Mass
42,876
Sequence
MAAVVAATALKGRGARNARVLRGILAGATANKASHNRTRALQSHSSPEGKEEPEPLSPELEYIPRKRGKNPMKAVGLAWYSLYTRTWLGYLFYRQQLRRARNRYPKGHSKTQPRLFNGVKVLPIPVLSDNYSYLIIDTQAQLAVAVDPSDPRAVQASIEKEGVTLVAILCTHKHWDHSGGNRDLSRRHRDCRVYGSPQDGIPYLTHPLCHQDVVSVGRLQIRALATPGHTQGHLVYLLDGEPYKGPSCLFSGDLLFLSGCGRTFEGNAETMLSSLDTVLGLGDDTLLWPGHEYAEENLGFAGVVEPENLARERKMQWVQRQRLERKGTCPSTLGEERSYNPFLRTHCLALQEALGPGPGPTGDDDYSRAQLLEELRRLKDMHKSK
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=MR-1L; IsoId=Q8N490-1; Sequence=Displayed; Name=2; Synonyms=MR-1S; IsoId=Q8N490-2; Sequence=VSP_027739, VSP_027740; Name=3; Synonyms=MR-1M; IsoId=Q8N490-3; Sequence=VSP_027736; Name=4; IsoId=Q8N490-4; Sequence=VSP_027737, VSP_027738
Alternative Sequence
1..79; MAAVVAATALKGRGARNARVLRGILAGATANKASHNRTRALQSHSSPEGKEEPEPLSPELEYIPRKRGKNPMKAVGLAW -> MAWQGWPAAWQWVAGCWLLLVLVLVLLVSPRGCRARRGLRGLLMAHSQRLLFRIG (in isoform 3); 1..60; Missing (in isoform 4); 61..78; EYIPRKRGKNPMKAVGLA -> MPSSVHHTKRQMMSIYCY (in isoform 4); 80..142; YSLYTRTWLGYLFYRQQLRRARNRYPKGHSKTQPRLFNGVKVLPIPVLSDNYSYLIIDTQAQL -> AIGFPCGILLFILTKREVDKDRVKQMKARQNMRLSNTGEYESQRFRASSQSAPSPDVGSGVQT (in isoform 2); 143..385; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Region
32..58; Disordered
Protein Families
- Metallo-beta-lactamase superfamily
- Glyoxalase II family
Sequence Similarities
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.