Protein detail

PNKD

Probable thioesterase PNKD (EC 3.1.2.-) (Myofibrillogenesis regulator 1) (MR-1) (Paroxysmal nonkinesiogenic dyskinesia protein) (Trans-activated by hepatitis C virus core protein 2)

Entry name PNKD	UniProt ID Q8N490	EVMP score 0.38
Frequency 2	Transmembrane count	Protein classification

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Probable thioesterase PNKD (EC 3.1.2.-) (Myofibrillogenesis regulator 1) (MR-1) (Paroxysmal nonkinesiogenic dyskinesia protein) (Trans-activated by hepatitis C virus core protein 2)

Protein Function

Predicted intracellular proteins
FDA approved drug targets:Biotech drugs

Ensembl

ENSG00000153029

Entrez Gene Symbol

MR1

Frequency

EVMP Score

0.38

Fluorescence & Localization

Cell SpecificOocytesBlood Cell Specificplasmacytoid DC

Function & Pathway

Protein Function

Predicted intracellular proteins
FDA approved drug targets:Biotech drugs

Cellular Component

Molecular Function

Biological Process

Mediation Categories

Fusion and delivery mediationImmune mediationMetabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

32 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane_sosui	transmembrane_predicted	Almen2009	No	No	Yes	Yes	No
transmembrane_tmhmm	transmembrane_predicted	Almen2009	No	No	Yes	Yes	No

Page 4 of 4Previous

Regulatory Interaction Network

0 records.

Protein Complex Composition

31 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
FMR1 RNA-binding homodimer	FMR1	Q06787	2	ComplexPortalPDB	PDB:4qvzPDB:5de8PDB:4qw2PDB:2QNDintact:EBI-46450114PDB:5de5PDB:4ovaPDB:5deaPDB:2qnd	14755292 17850748 32878499 30765518
FMR1-FXR1 RNA-binding complex	FMR1 FXR1	P51114 Q06787	1:1	ComplexPortal	intact:EBI-46450456	30765518 7489725 14755292 17850748 32878499
FMR1-FXR2 RNA-binding complex	FMR1 FXR2	P51116 Q06787	1:1	ComplexPortal		30765518 7489725 14755292 17850748 32878499
Fmrp-Lgl complex	FMR1 LLGL1 LLGL2	Q06787 Q15334 Q6P1M3	1:1:1	Compleat	Compleat:HC2444	15621528
eIF4E-CYFIP1-FMRP translational repressor complex	CYFIP1 EIF4E FMR1	P06730 Q06787 Q7L576	1:1:1	ComplexPortal		26013047 14755292 18805096
mRNA cap binding complex	AGO2 CYFIP1 EIF4E EIF4E1B EIF4E2 EIF4E3 FMR1 NCBP1 NCBP2 PIWIL1 RAMAC RNMT	A6NMX2 O43148 O60573 P06730 P52298 Q06787 Q09161 Q7L576 Q8N5X7 Q96J94 Q9BTL3 Q9UKV8	1:1:1:1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC972	16271312 17524464 12434151 17368478
	CALCOCO2 FMR1 FXR2 RB1CC1 TBK1 TBKBP1 UBC	A7MCY6 P0CG48 P51116 Q06787 Q13137 Q8TDY2 Q9UHD2	1:1:1:1:1:1:1	CompleatCFinder	Compleat:HC5818
	CALCOCO2 FMR1 FXR2 TBK1 TBKBP1	A7MCY6 P51116 Q06787 Q13137 Q9UHD2	1:1:1:1:1	CompleatCFinder	Compleat:HC6915
	BRD3 FAM90A1 FAM90A26 FAM90A5 KDM5B MTMR14	A8MXJ8 D6RGX4 Q15059 Q86YD7 Q8NCE2 Q9UGL1	0:0:0:0:0:0	hu.MAP
	FAM90A1 FAM90A26 FAM90A5 KDM5B MTMR14	A8MXJ8 D6RGX4 Q86YD7 Q8NCE2 Q9UGL1	0:0:0:0:0	hu.MAP

Page 1 of 4Next

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	38716512

Sequence, Structure & Domains

Sequences

Length

385

Mass

42,876

Sequence

MAAVVAATALKGRGARNARVLRGILAGATANKASHNRTRALQSHSSPEGKEEPEPLSPELEYIPRKRGKNPMKAVGLAWYSLYTRTWLGYLFYRQQLRRARNRYPKGHSKTQPRLFNGVKVLPIPVLSDNYSYLIIDTQAQLAVAVDPSDPRAVQASIEKEGVTLVAILCTHKHWDHSGGNRDLSRRHRDCRVYGSPQDGIPYLTHPLCHQDVVSVGRLQIRALATPGHTQGHLVYLLDGEPYKGPSCLFSGDLLFLSGCGRTFEGNAETMLSSLDTVLGLGDDTLLWPGHEYAEENLGFAGVVEPENLARERKMQWVQRQRLERKGTCPSTLGEERSYNPFLRTHCLALQEALGPGPGPTGDDDYSRAQLLEELRRLKDMHKSK

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=MR-1L; IsoId=Q8N490-1; Sequence=Displayed; Name=2; Synonyms=MR-1S; IsoId=Q8N490-2; Sequence=VSP_027739, VSP_027740; Name=3; Synonyms=MR-1M; IsoId=Q8N490-3; Sequence=VSP_027736; Name=4; IsoId=Q8N490-4; Sequence=VSP_027737, VSP_027738

Alternative Sequence

1..79; MAAVVAATALKGRGARNARVLRGILAGATANKASHNRTRALQSHSSPEGKEEPEPLSPELEYIPRKRGKNPMKAVGLAW -> MAWQGWPAAWQWVAGCWLLLVLVLVLLVSPRGCRARRGLRGLLMAHSQRLLFRIG (in isoform 3); 1..60; Missing (in isoform 4); 61..78; EYIPRKRGKNPMKAVGLA -> MPSSVHHTKRQMMSIYCY (in isoform 4); 80..142; YSLYTRTWLGYLFYRQQLRRARNRYPKGHSKTQPRLFNGVKVLPIPVLSDNYSYLIIDTQAQL -> AIGFPCGILLFILTKREVDKDRVKQMKARQNMRLSNTGEYESQRFRASSQSAPSPDVGSGVQT (in isoform 2); 143..385; Missing (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Region

32..58; Disordered

Protein Families

Metallo-beta-lactamase superfamily
Glyoxalase II family

Sequence Similarities

Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

Clinical Relevance

Drugs

ANTI-THYMOCYTE GLOBULIN