Protein detail

CCD24

Coiled-coil domain-containing protein 24

Entry name CCD24	UniProt ID Q8N4L8	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Coiled-coil domain-containing protein 24

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000159214

Entrez Gene Symbol

CCDC24

Gene Synonym

MGC45441

Gene Description

Coiled-coil domain containing 24

Chromosome

Position

43991359-43996528

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization2

Cell SpecificChoroid plexus epithelial cellsSingle-Nuclei Brain Specifichippocampal CA4

Function & Pathway5

Protein Function

Predicted intracellular proteins

Molecular Function

GO:0005515 protein binding

Biological Process (3)

Canonical Pathways (2)

M117 Pid cone pathway
M204 Pid rhodopsin pathway

Mediation Categories

Other mediation

Relations & Evidence3

Ligand-Receptor Signaling (2)

2 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	10	39408670 40596376 38037300 34265469 40689422 33799461 39948040 38576002 39996590 36573687

Sequence, Structure & Domains8

Sequences

Length

307

Mass

34,322

Sequence

MLRHSPSLWELVEEHVPLRERREVKRILGEAAVDLSLELRAEVAMLRALLQEARSSQAPSSRPISDPSSLLAPPPLLKDLLRQELRQLLQGLRHKAICEGRDQAQAWVQYSPRVLHFALEEPRCDLPEQEIFQMRGGGPSSGHRDLSIIKDQLNVSNIDQVARHLRGLLEEECHTLEREILILQRCLEEEYLRPCHPSEAALEPTLAELKEQKKAMEQELQASVGPSCVSPNHRQRPLGSSTQGLRPPLPLCGVAPLQCCLPAPPLEPYLRPRGQSATHRWGRQLQCSPREGPASTPMSSAAPQAPA

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8N4L8-1; Sequence=Displayed; Name=2; IsoId=Q8N4L8-2; Sequence=VSP_018148

Alternative Sequence

43..78; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

296..307; Polar residues

Coiled Coil

168..225

Region

223..245; Disordered; 271..307; Disordered

Clinical Relevance1

Antibody (2)

HPA035424 HPA061710

Supporting Publications1

PMID	Title	Abstract
38343172	Analysis of secreted small extracellular vesicles from activated human microglial cell lines reveals distinct pro- and anti-inflammatory proteomic profiles.	No abstract available