Protein detail
ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein (G patch domain-containing protein 6) (Zinc finger CCCH domain-containing protein 9) (Zinc finger and G patch domain-containing protein)
Entry name ZGPAT | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information6
Protein Names
Zinc finger CCCH-type with G patch domain-containing protein (G patch domain-containing protein 6) (Zinc finger CCCH domain-containing protein 9) (Zinc finger and G patch domain-containing protein)
Protein Function (2)
- Predicted intracellular proteins
- Transcription factors:Zinc-coordinating DNA-binding domains
Ensembl
Entrez Gene Symbol
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization7
Tissue Specificheart muscleBrain Regional Specificcerebral cortexCell SpecificMyonucleiSingle-Nuclei Brain Specificamygdala excitatoryBlood Cell SpecificNK-cellBlood Lineage SpecificNK-cells
Function & Pathway5
Protein Function (2)
- Predicted intracellular proteins
- Transcription factors:Zinc-coordinating DNA-binding domains
Cellular Component (4)
Molecular Function (7)
- GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
- GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
- GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
- GO:0003700 DNA-binding transcription factor activity
- GO:0005515 protein binding
- GO:0043565 sequence-specific DNA binding
- GO:0046872 metal ion binding
Biological Process (3)
Mediation Categories
Receptor-signaling mediation
Relations & Evidence13
Ligand-Receptor Signaling (7)
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane | GO_Intercell | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
Protein Complex Composition (5)
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| BEST1ZGPAT | O76090Q8N5A5 | 0:0 | hu.MAP2 | |||
| LSM5POLHRAD23ATMCO6ZGPATZNF511 | P54725Q8N5A5Q8NB15Q96DC7Q9Y253Q9Y4Y9 | 0:0:0:0:0:0 | hu.MAP2 | |||
| SPIN1SPIN4TOPORSYRDCZGPAT | Q56A73Q86U90Q8N5A5Q9NS56Q9Y657 | 0:0:0:0:0 | hu.MAP | |||
| ZGPAT | Q8N5A5 | 4 | PDB | PDB:4ii1 | ||
| SPIN1TOPORSZGPAT | Q8N5A5Q9NS56Q9Y657 | 0:0:0 | hu.MAP |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 39409015 |
Sequence, Structure & Domains12
Sequences
Length
531
Mass
57,359
Sequence
MDEESLESALQTYRAQLQQVELALGAGLDSSEQADLRQLQGDLKELIELTEASLVSVRKSSLLAALDEERPGRQEDAEYQAFREAITEAVEAPAAARGSGSETVPKAEAGPESAAGGQEEEEGEDEEELSGTKVSAPYYSSWGTLEYHNAMVVGTEEAEDGSAGVRVLYLYPTHKSLKPCPFFLEGKCRFKENCRFSHGQVVSLDELRPFQDPDLSSLQAGSACLAKHQDGLWHAARITDVDNGYYTVKFDSLLLREAVVEGDGILPPLRTEATESDSDSDGTGDSSYARVVGSDAVDSAQSSALCPSLAVVGSDAVDSGTCSSAFAGWEVHTRGIGSRLLTKMGYEFGKGLGRHAEGRVEPIHAVVLPRGKSLDQCVETLQKQTRVGKAGTNKPPRCRGRGARPGGRPAPRNVFDFLNEKLQGQAPGALEAGAAPAGRRSKDMYHASKSAKRALSLRLFQTEEKIERTQRDIRSIQEALARNAGRHSVASAQLQEKLAGAQRQLGQLRAQEAGLQQEQRKADTHKKMTEF
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8N5A5-1; Sequence=Displayed; Name=2; IsoId=Q8N5A5-2; Sequence=VSP_007754; Name=3; IsoId=Q8N5A5-3; Sequence=VSP_038121; Name=4; Synonyms=sZIP; IsoId=Q8N5A5-4; Sequence=VSP_053599
Alternative Sequence
1..343; Missing (in isoform 4); 282..310; Missing (in isoform 3); 291..310; Missing (in isoform 2)
3D Structural Models
Helix
175..177; 183..185; 204..206; 262..264
Beta Strand
133..138; 146..157; 163..171; 195..197; 200..203; 223..227; 233..244; 246..252; 258..260
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
107..117; Low complexity; 118..129; Acidic residues; 426..438; Low complexity; 518..531; Basic and acidic residues
Zinc Finger
175..201; C3H1-type
Domain (FT)
333..379; G-patch
Region
91..133; Disordered; 267..289; Disordered; 385..409; Disordered; 426..446; Disordered; 509..531; Disordered
Clinical Relevance3
Interaction Protein
ENSG00000109606
Interaction Count
1
Interaction Dataset
intact_biogrid
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 36550367 | Surface protein profiling of prostate-derived extracellular vesicles by mass spectrometry and proximity assays. | No abstract available |