Protein detail
M4A15
Membrane-spanning 4-domains subfamily A member 15
Entry name M4A15 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 4 | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information7
Protein Names
Membrane-spanning 4-domains subfamily A member 15
Transmembrane
73..93; Helical; 100..120; Helical; 144..164; Helical; 173..193; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization3
Cell SpecificAlveolar cells type 1Single-Nuclei Brain SpecificoligodendrocyteBlood Cell Specificclassical monocyte
Function & Pathway3
Cellular Component
Biological Process (3)
Mediation Categories
Other mediation
Relations & Evidence9
Ligand-Receptor Signaling (8)
8 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | No | No |
| cell_surface | cell_surface | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture | Mass spectrometryWestern blottingMORPHELISA | 13 | 40985879379267563606464738113368373224753649718440189497410682533359250038891077329169864130796840840701 |
Sequence, Structure & Domains7
Sequences
Length
240
Mass
25,050
Sequence
MSAAPASNGVFVVIPPNNASGLCPPPAILPTSMCQPPGIMQFEEPPLGAQTPRATQPPDLRPVETFLTGEPKVLGTVQILIGLIHLGFGSVLLMVRRGHVGIFFIEGGVPFWGGACFIISGSLSVAAEKNHTSCLVRSSLGTNILSVMAAFAGTAILLMDFGVTNRDVDRGYLAVLTIFTVLEFFTAVIAMHFGCQAIHAQASAPVIFLPNAFSADFNIPSPAASAPPAYDNVAYAQGVV
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8N5U1-1; Sequence=Displayed; Name=2; IsoId=Q8N5U1-2; Sequence=VSP_031669; Name=3; IsoId=Q8N5U1-3; Sequence=VSP_053907
Alternative Sequence
1..93; Missing (in isoform 2); 76..116; Missing (in isoform 3)
Domain & Motif Annotations
Protein Families
MS4A family
Sequence Similarities
Belongs to the MS4A family.
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 39277144 | The proteomic signature of circulating extracellular vesicles following intracerebral hemorrhage: Novel insights into mechanisms underlying recovery. | No abstract available |