Protein detail
AADAT
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (KAT/AadAT) (2-aminoadipate aminotransferase) (2-aminoadipate transaminase) (EC 2.6.1.39) (Alpha-aminoadipate aminotransferase) (AadAT) (Glycine transaminase AADAT) (EC 2.6.1.4) (Kynurenine aminotransferase II) (Kynurenine--glyoxylate transaminase AADAT) (EC 2.6.1.63) (Kynurenine--oxoglutarate aminotransferase II) (Kynurenine--oxoglutarate transaminase 2) (EC 2.6.1.7) (Kynurenine--oxoglutarate transaminase II) (Methionine--glyoxylate transaminase AADAT) (EC 2.6.1.73)
Entry name AADAT | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count | Protein classification EnzymesMetabolic proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (KAT/AadAT) (2-aminoadipate aminotransferase) (2-aminoadipate transaminase) (EC 2.6.1.39) (Alpha-aminoadipate aminotransferase) (AadAT) (Glycine transaminase AADAT) (EC 2.6.1.4) (Kynurenine aminotransferase II) (Kynurenine--glyoxylate transaminase AADAT) (EC 2.6.1.63) (Kynurenine--oxoglutarate aminotransferase II) (Kynurenine--oxoglutarate transaminase 2) (EC 2.6.1.7) (Kynurenine--oxoglutarate transaminase II) (Methionine--glyoxylate transaminase AADAT) (EC 2.6.1.73)
Protein Class (3)
EnzymesMetabolic proteinsPredicted intracellular proteins
Protein Function (3)
- ENZYME proteins:Transferases
- Enzymes
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
KAT2KATIIKYAT2
Gene Description
Aminoadipate aminotransferase
Chromosome
4
Position
170060222-170091699
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization4
Tissue Specificblood vesselCell SpecificEarly spermatidsSingle-Nuclei Brain Specificamygdala excitatory
Function & Pathway7
Protein Function (3)
- ENZYME proteins:Transferases
- Enzymes
- Predicted intracellular proteins
Cellular Component (2)
Molecular Function (7)
- GO:0016212 kynurenine-oxoglutarate transaminase activity
- GO:0030170 pyridoxal phosphate binding
- GO:0042803 protein homodimerization activity
- GO:0047315 kynurenine-glyoxylate transaminase activity
- GO:0047536 2-aminoadipate transaminase activity
- GO:0047958 glycine:2-oxoglutarate aminotransferase activity
- GO:0050094 methionine-glyoxylate transaminase activity
Biological Process (3)
KEGG (4)
Reactome (3)
Mediation Categories (2)
Clinical-translation mediationMetabolism mediation
Relations & Evidence8
Ligand-Receptor Signaling (5)
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Protein Complex Composition (2)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Polymer Precipitation | Western blotting | 1 | 38731868 |
Sequence, Structure & Domains13
Sequences
Length
425
Mass
47,352
Sequence
MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQLIKESL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8N5Z0-1; Sequence=Displayed; Name=2; IsoId=Q8N5Z0-2; Sequence=VSP_009874
Alternative Sequence
23; T -> SEKRA (in isoform 2)
3D Structural Models
Turn
56..58; 98..101; 202..204; 232..235; 262..265; 267..270; 290..292; 341..344; 372..378; 402..404
Helix
3..6; 9..13; 19..21; 23..27; 43..45; 65..71; 81..95; 104..106; 117..128; 143..149; 150..152; 168..175; 180..184; 186..188; 210..223; 247..249; 278..289; 297..340; 368..371; 384..387; 407..422
Beta Strand
51..53; 61..63; 109..116; 134..137; 155..158; 193..196; 226..230; 239..241; 251..253; 255..261; 272..277; 293..295; 345..347; 351..360; 381..383; 388..390; 391..393; 397..401
3D Structure
X-ray crystallography (17)
Domain & Motif Annotations
Compositional Bias
198..208; Polar residues
Region
181..208; Disordered
Protein Families
Class-I pyridoxal-phosphate-dependent aminotransferase family
Sequence Similarities
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Clinical Relevance4
Related Diseases (2)
Biomarker
Preclinical
Drugs
Antibody
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 22655043 | Shifting the paradigm: the putative mitochondrial protein ABCB6 resides in the lysosomes of cells and in the plasma membrane of erythrocytes. | Consistent with its presence in exosomes, endogenous ABCB6 is localized to the endo/lysosomal compartment, and is absent from the mitochondria of cells. Here we show that ABCB6 is a glycoprotein present in the membrane of mature erythrocytes and in exosomes released from reticulocytes during the final steps of erythroid maturation. |