Protein detail
SC5A8
Sodium-coupled monocarboxylate transporter 1 (Apical iodide transporter) (Electrogenic sodium monocarboxylate cotransporter) (Sodium iodide-related cotransporter) (Solute carrier family 5 member 8)
Protein symbol SC5A8 | UniProt ID | EVMP score 0.38 |
Frequency | Transmembrane count 13 | Protein classification |
Basic Information
Protein Names
Sodium-coupled monocarboxylate transporter 1 (Apical iodide transporter) (Electrogenic sodium monocarboxylate cotransporter) (Sodium iodide-related cotransporter) (Solute carrier family 5 member 8)
Protein Function
Transporters:Electrochemical Potential-driven transporters
Transmembrane
10..30; Helical; 52..72; Helical; 84..104; Helical; 133..153; Helical; 162..182; Helical; 190..210; Helical; 240..260; Helical; 280..300; Helical; 337..359; Helical; 390..410; Helical; 416..436; Helical; 440..460; Helical; 519..539; Helical
Transmembrane Count
13
Ensembl
Entrez Gene Symbol
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificEsophageal apical cells
Function & Pathway
Protein Function
Transporters:Electrochemical Potential-driven transporters
Cellular Component
Molecular Function
- GO:0005343 organic acid:sodium symporter activity
- GO:0005515 protein binding
- GO:0008028 monocarboxylic acid transmembrane transporter activity
- GO:0015129 lactate transmembrane transporter activity
- GO:0015552 propionate transmembrane transporter activity
- GO:0140161 monocarboxylate:sodium symporter activity
- GO:0160081 iodide channel activity
Biological Process
Reactome
- R-hsa-196854 metabolism of vitamins and cofactors
- R-hsa-196849 metabolism of water soluble vitamins and cofactors
- R-hsa-196807 nicotinate metabolism
- R-hsa-428643 organic anion transport by slc5 17 25 transporters
- R-hsa-425407 slc mediated transmembrane transport
- R-hsa-9958790 slc mediated transport of inorganic anions
- R-hsa-9955298 slc mediated transport of organic anions
- R-hsa-382551 transport of small molecules
Mediation Categories
Fusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
24 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | TopDB | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| apical_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| apical_cell_membrane | plasma_membrane | Ramilowski_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | Ramilowski_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass Spectrometry | 1 | 33709510 |
Sequence, Structure & Domains
Sequences
Length
610
Mass
66,578
Sequence
MDTPRGIGTFVVWDYVVFAGMLVISAAIGIYYAFAGGGQQTSKDFLMGGRRMTAVPVALSLTASFMSAVTVLGTPSEVYRFGAIFSIFAFTYFFVVVISAEVFLPVFYKLGITSTYEYLELRFNKCVRLCGTVLFIVQTILYTGIVIYAPALALNQVTGFDLWGAVVATGVVCTFYCTLGGLKAVIWTDVFQVGIMVAGFASVIIQAVVMQGGISTILNDAYDGGRLNFWNFNPNPLQRHTFWTIIIGGTFTWTSIYGVNQSQVQRYISCKSRFQAKLSLYINLVGLWAILTCSVFCGLALYSRYHDCDPWTAKKVSAPDQLMPYLVLDILQDYPGLPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPYFRSLSERSLSWISQGMSVVYGALCIGMAALASLMGALLQAALSVFGMVGGPLMGLFALGILVPFANSIGALVGLMAGFAISLWVGIGAQIYPPLPERTLPLHLDIQGCNSTYNETNLMTTTEMPFTTSVFQIYNVQRTPLMDNWYSLSYLYFSTVGTLVTLLVGILVSLSTGGRKQNLDPRYILTKEDFLSNFDIFKKKKHVLSYKSHPVEDGGTDNPAFNHIELNSDQSGKSNGTRL
3D Structural Models
Turn
115..118; 175..180; 516..518
Helix
15..33; 55..65; 69..72; 74..81; 82..87; 88..101; 104..109; 119..122; 126..129; 132..158; 164..174; 187..211; 214..223; 242..257; 261..263; 265..268; 273..304; 319..321; 323..330; 338..368; 378..385; 387..402; 411..418; 421..432; 439..462; 467..470; 511..515; 526..532; 534..542
Beta Strand
12..14; 66..68; 181..183; 238..240; 270..272; 305..308; 310..314; 331..334; 369..372; 405..410
3D Structure
Electron microscopy (1)
Domain & Motif Annotations
Compositional Bias
596..610; Polar residues
Motif
608..610; PDZ-binding
Region
585..610; Disordered
Protein Families
Sodium:solute symporter (SSF) (TC 2.A.21) family
Sequence Similarities
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.