Protein detail

MET25

Probable methyltransferase-like protein 25 (EC 2.1.1.-)

Entry name MET25	UniProt ID Q8N6Q8	EVMP confidence score 0.38
Supporting publications (n) 2	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Probable methyltransferase-like protein 25 (EC 2.1.1.-)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000127720

Entrez Gene Symbol

METTL25

Gene Synonym (2)

C12orf26FLJ22789

Gene Description

Methyltransferase like 25

Chromosome

Position

82358528-82479239

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization1

Cell SpecificColonocytes

Function & Pathway4

Protein Function

Predicted intracellular proteins

Molecular Function

GO:0008168 methyltransferase activity

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence3

Ligand-Receptor Signaling (2)

2 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyPolymer PrecipitationImmunoaffinity Capture	Mass spectrometryMass spectrometry [LTQ-FT Ultra]	42	40985879 37926756 36064647 38113368 40465195 37322475 33304478 36497184 25755179 34064677 40189497 38895962 41068253 33592500 32854315 38014595 27487081 34473505 38891077 38917926 30915084 32560723 32679547 32916986 41307968 36146834 35763629 37569298 33309826 40840701 37670049 31805958 38607062 32230970 38207106 34576246 37204515 33905554 39001700 36982312 37438638 39207047

Sequence, Structure & Domains4

Sequences

Length

603

Mass

68,213

Sequence

MAASCPLPVTPDLPTLRAKLQGLLQFLRDALSISNAHTVDFYTESVWEELVDLPPETVLAALRKSASETEALPSETRPLVEAEWEAGMTDFPKIFCETSQKLVSVEAFALAAKYYSVQNLGICTPFEQLLVALRGNQNQRIGENQKAVEFMNMKKSHEVQAMSELISSIADYYGIKQVIDLGSGKGYLSSFLSLKYGLKVYGIDSSNTNTHGAEERNRKLKKHWKLCHAQSRLDVNGLALKMAKERKVQNKVKNKADTEEVFNNSPTNQEKMPTSAILPDFSGSVISNIRNQMETLHSQPHQEENLCFENSFSLINLLPINAVEPTSSQQIPNRETSEANKERRKMTSKSSESNIYSPLTSFITADSELHDIIKDLEDCLMVGLHTCGDLAPNTLRIFTSNSEIKGVCSVGCCYHLLSEEFENQHKERTQEKWGFPMCHYLKEERWCCGRNARMSACLALERVAAGQGLPTESLFYRAVLQDIIKDCYGITKCDRHVGKIYSKCSSFLDYVRRSLKKLGLDESKLPEKIIMNYYEKYKPRMNELEAFNMLKVVLAPCIETLILLDRLCYLKEQEDIAWSALVKLFDPVKSPRCYAVIALKKQQ

Domain & Motif Annotations

Region

326..352; Disordered

Clinical Relevance1

Antibody (2)

HPA039534 HPA041207

Supporting Publications2

PMID	Title	Abstract
33893753	Label-free quantitative proteomic analysis of extracellular vesicles released from fibroblasts derived from patients with spinal muscular atrophy.	No abstract available
38207106	Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.	No abstract available