Protein detail

TRIMM

Probable E3 ubiquitin-protein ligase TRIML2 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIML2) (SPRY domain-containing protein 6) (Tripartite motif family-like protein 2)

Protein symbol TRIMM	UniProt ID Q8N7C3	EVMP score 0.38
Frequency 1	Transmembrane count	Protein classification EnzymesPredicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Probable E3 ubiquitin-protein ligase TRIML2 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIML2) (SPRY domain-containing protein 6) (Tripartite motif family-like protein 2)

Protein Class

EnzymesPredicted intracellular proteins

Protein Function

ENZYME proteins:Transferases
Enzymes
Predicted intracellular proteins

Ensembl

ENSG00000179046

Entrez Gene Symbol

TRIML2

Gene Synonym

FLJ25801SPRYD6

Gene Description

Tripartite motif family like 2

Chromosome

Position

188091272-188109603

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue SpecificbrainCell SpecificAstrocytesSingle-Nuclei Brain SpecificastrocyteBlood Cell Specificclassical monocyteBlood Lineage Specificdendritic cells

Function & Pathway

Protein Function

ENZYME proteins:Transferases
Enzymes
Predicted intracellular proteins

Cellular Component

GO:0005737 cytoplasm

Molecular Function

Biological Process

Canonical Pathways

M156 Pid ecadherin nascent aj pathway
M232 Pid ecadherin stabilization pathway
M81 Pid cdc42 pathway

Mediation Categories

Other mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

3 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Western blotting	2	38731868 33709510

Sequence, Structure & Domains

Sequences

Length

437

Mass

49,893

Sequence

MSKRLSPQLQHNITEDAYCETHLEPTRLFCDVDQITLCSKCFQSQEHKHHMVCGIQEAAENYRKLFQEILNTSREKLEAAKSILTDEQERMAMIQEEEQNFKKMIESEYSMRLRLLNEECEQNLQRQQECISDLNLRETLLNQAIKLATELEEMFQEMLQRLGRVGRENMEKLKESEARASEQVRSLLKLIVELEKKCGEGTLALLKNAKYSLERSKSLLLEHLEPAHITDLSLCHIRGLSSMFRVLQRHLTLDPETAHPCLALSEDLRTMRLRHGQQDGAGNPERLDFSAMVLAAESFTSGRHYWEVDVEKATRWQVGIYHGSADAKGSTARASGEKVLLTGSVMGTEWTLWVFPPLKRLFLEKKLDTVGVFLDCEHGQISFYNVTEMSLIYNFSHCAFQGALRPVFSLCIPNGDTSPDSLTILQHGPSCDATVSP

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8N7C3-1; Sequence=Displayed; Name=2; IsoId=Q8N7C3-2; Sequence=VSP_055447, VSP_055448

Alternative Sequence

208..221; NAKYSLERSKSLLL -> VRCWEKENKIHSSI (in isoform 2); 222..437; Missing (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Coiled Coil

55..200

Zinc Finger

14..55; B box-type

Domain (FT)

231..429; B30.2/SPRY

Clinical Relevance

Antibody

HPA043838

Interaction Protein

ENSG00000119242ENSG00000177485ENSG00000196072

Interaction Count

Interaction Dataset

intact_biogrid