Protein detail

TRIMM

Probable E3 ubiquitin-protein ligase TRIML2 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIML2) (SPRY domain-containing protein 6) (Tripartite motif family-like protein 2)

Entry name TRIMM	UniProt ID Q8N7C3	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification EnzymesPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Probable E3 ubiquitin-protein ligase TRIML2 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIML2) (SPRY domain-containing protein 6) (Tripartite motif family-like protein 2)

Protein Class (2)

EnzymesPredicted intracellular proteins

Protein Function (3)

ENZYME proteins:Transferases
Enzymes
Predicted intracellular proteins

Ensembl

ENSG00000179046

Entrez Gene Symbol

TRIML2

Gene Synonym (2)

FLJ25801SPRYD6

Gene Description

Tripartite motif family like 2

Chromosome

Position

188091272-188109603

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization5

Tissue SpecificbrainCell SpecificAstrocytesSingle-Nuclei Brain SpecificastrocyteBlood Cell Specificclassical monocyteBlood Lineage Specificdendritic cells

Function & Pathway6

Protein Function (3)

ENZYME proteins:Transferases
Enzymes
Predicted intracellular proteins

Cellular Component

GO:0005737 cytoplasm

Molecular Function (4)

Biological Process (3)

Canonical Pathways (3)

M156 Pid ecadherin nascent aj pathway
M232 Pid ecadherin stabilization pathway
M81 Pid cdc42 pathway

Mediation Categories

Other mediation

Relations & Evidence4

Ligand-Receptor Signaling (3)

3 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Western blotting	2	38731868 33709510

Sequence, Structure & Domains8

Sequences

Length

437

Mass

49,893

Sequence

MSKRLSPQLQHNITEDAYCETHLEPTRLFCDVDQITLCSKCFQSQEHKHHMVCGIQEAAENYRKLFQEILNTSREKLEAAKSILTDEQERMAMIQEEEQNFKKMIESEYSMRLRLLNEECEQNLQRQQECISDLNLRETLLNQAIKLATELEEMFQEMLQRLGRVGRENMEKLKESEARASEQVRSLLKLIVELEKKCGEGTLALLKNAKYSLERSKSLLLEHLEPAHITDLSLCHIRGLSSMFRVLQRHLTLDPETAHPCLALSEDLRTMRLRHGQQDGAGNPERLDFSAMVLAAESFTSGRHYWEVDVEKATRWQVGIYHGSADAKGSTARASGEKVLLTGSVMGTEWTLWVFPPLKRLFLEKKLDTVGVFLDCEHGQISFYNVTEMSLIYNFSHCAFQGALRPVFSLCIPNGDTSPDSLTILQHGPSCDATVSP

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8N7C3-1; Sequence=Displayed; Name=2; IsoId=Q8N7C3-2; Sequence=VSP_055447, VSP_055448

Alternative Sequence

208..221; NAKYSLERSKSLLL -> VRCWEKENKIHSSI (in isoform 2); 222..437; Missing (in isoform 2)

Domain & Motif Annotations

Coiled Coil

55..200

Zinc Finger

14..55; B box-type

Domain (FT)

231..429; B30.2/SPRY

Clinical Relevance4

Antibody

HPA043838

Interaction Protein (3)

ENSG00000119242ENSG00000177485ENSG00000196072

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications1

PMID	Title	Abstract
40748658	Exosomes released from senescent cells and circulatory exosomes isolated from human plasma reveal aging-associated proteomic and lipid signatures.	No abstract available