Protein detail

NLS1

Sodium-dependent lysophosphatidylcholine symporter 1 (NLS1) (Sodium-dependent LPC symporter 1) (Major facilitator superfamily domain-containing protein 2A) (HsMFSD2A) (MFSD2a)

Entry name NLS1	UniProt ID Q8NA29	EVMP confidence score 0.50
Supporting publications (n) 2	Transmembrane count 12	Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Sodium-dependent lysophosphatidylcholine symporter 1 (NLS1) (Sodium-dependent LPC symporter 1) (Major facilitator superfamily domain-containing protein 2A) (HsMFSD2A) (MFSD2a)

Protein Class (5)

Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters

Protein Function (4)

Transporters:Electrochemical Potential-driven transporters
Disease related genes
Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
Potential drug targets

Transmembrane

41..70; Helical; 95..115; Helical; 128..147; Helical; 158..182; Helical; 190..221; Helical; 242..275; Helical; 307..333; Helical; 345..363; Helical; 368..389; Helical; 393..429; Helical; 440..466; Helical; 479..502; Helical

Transmembrane Count

Ensembl

ENSG00000168389

Entrez Gene Symbol

MFSD2A

Gene Synonym (3)

FLJ14490MFSD2SLC59A1

Gene Description

Major facilitator superfamily domain containing 2A

Chromosome

Position

39955112-39969968

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization4

Tissue SpecificbrainBrain Regional SpecificcerebellumCell SpecificBreast myoepithelial cellsSingle-Nuclei Brain Specifichippocampal CA4

Function & Pathway6

Protein Function (4)

Transporters:Electrochemical Potential-driven transporters
Disease related genes
Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
Potential drug targets

Cellular Component (3)

Molecular Function (7)

Biological Process (3)

Reactome (4)

Mediation Categories (2)

Fusion and delivery mediationMetabolism mediation

Relations & Evidence19

Ligand-Receptor Signaling (18)

18 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No
cell_surface	cell_surface	Surfaceome	No	No	No	No	No
cell_surface	cell_surface	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometryWestern blottingELISA	3	39443544 38731868 37686366

Sequence, Structure & Domains10

Sequences

Length

543

Mass

60,170

Sequence

MAKGEGAESGSAAGLLPTSILQSTERPAQVKKEPKKKKQQLSVCNKLCYALGGAPYQVTGCALGFFLQIYLLDVAQKDEEVVFCFSSFQVGPFSASIILFVGRAWDAITDPLVGLCISKSPWTCLGRLMPWIIFSTPLAVIAYFLIWFVPDFPHGQTYWYLLFYCLFETMVTCFHVPYSALTMFISTEQTERDSATAYRMTVEVLGTVLGTAIQGQIVGQADTPCFQDLNSSTVASQSANHTHGTTSHRETQKAYLLAAGVIVCIYIICAVILILGVREQREPYEAQQSEPIAYFRGLRLVMSHGPYIKLITGFLFTSLAFMLVEGNFVLFCTYTLGFRNEFQNLLLAIMLSATLTIPIWQWFLTRFGKKTAVYVGISSAVPFLILVALMESNLIITYAVAVAAGISVAAAFLLPWSMLPDVIDDFHLKQPHFHGTEPIFFSFYVFFTKFASGVSLGISTLSLDFAGYQTRGCSQPERVKFTLNMLVTMAPIVLILLGLLLFKMYPIDEERRRQNKKALQALRDEASSSGCSETDSTELASIL

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8NA29-1; Sequence=Displayed; Name=2; IsoId=Q8NA29-2; Sequence=VSP_022539; Name=3; IsoId=Q8NA29-3; Sequence=VSP_022540

Alternative Sequence

1..186; MAKGEGAESGSAAGLLPTSILQSTERPAQVKKEPKKKKQQLSVCNKLCYALGGAPYQVTGCALGFFLQIYLLDVAQKDEEVVFCFSSFQVGPFSASIILFVGRAWDAITDPLVGLCISKSPWTCLGRLMPWIIFSTPLAVIAYFLIWFVPDFPHGQTYWYLLFYCLFETMVTCFHVPYSALTMFIS -> MWLRWALSLPPSSCLWAEPGMPSQTPWWASASANPPGPAWVALCPGSSSPRPWPSLPTSSSGSCPTSHTARPIGTCFSIASLKQWSRVSMFPTRLSPCSSA (in isoform 3); 77..89; Missing (in isoform 2)

3D Structural Models

3D Structure

Electron microscopy (1)

Domain & Motif Annotations

Compositional Bias

1..14; Low complexity

Region

1..34; Disordered

Protein Families

Major facilitator superfamily

Sequence Similarities

Belongs to the major facilitator superfamily.

Clinical Relevance2

Disease Involvement (2)

Disease variantPrimary microcephaly

Antibody

HPA043107

Supporting Publications2

PMID	Title	Abstract
27605433	Secreted primary human malignant mesothelioma exosome signature reflects oncogenic cargo.	No abstract available
28396511	Database-augmented Mass Spectrometry Analysis of Exosomes Identifies Claudin 3 as a Putative Prostate Cancer Biomarker.	No abstract available