Protein detail

S43A3

Equilibrative nucleobase transporter 1 (Protein FOAP-13) (Solute carrier family 43 member 3)

Entry name S43A3	UniProt ID Q8NBI5	EVMP confidence score 0.60
Supporting publications (n) 13	Transmembrane count 12	Protein classification Predicted intracellular proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Equilibrative nucleobase transporter 1 (Protein FOAP-13) (Solute carrier family 43 member 3)

Protein Class (3)

Predicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function (2)

Transporters:Electrochemical Potential-driven transporters
Predicted intracellular proteins

Transmembrane

17..37; Helical; 72..92; Helical; 102..122; Helical; 123..143; Helical; 156..176; Helical; 188..208; Helical; 279..299; Helical; 319..339; Helical; 356..376; Helical; 396..418; Helical; 427..447; Helical; 456..476; Helical

Transmembrane Count

Ensembl

ENSG00000134802

Entrez Gene Symbol

SLC43A3

Gene Synonym (5)

DKFZp762A227Eeg1FOAP-13PRO1659SEEEG-1

Gene Description

Solute carrier family 43 member 3

Chromosome

Position

57406954-57427580

Supporting publications (n)

EVMP confidence score

0.60

Function & Pathway4

Protein Function (2)

Transporters:Electrochemical Potential-driven transporters
Predicted intracellular proteins

Cellular Component

GO:0016323 basolateral plasma membrane

Molecular Function (5)

Mediation Categories (2)

Clinical-translation mediationFusion and delivery mediation

Relations & Evidence22

Ligand-Receptor Signaling (21)

21 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transporter	transporter	Surfaceome	No	Yes	No	No	No
mfs	transporter	Surfaceome	No	Yes	No	No	No
slc43	transporter	Surfaceome	No	Yes	No	No	No
slc	transporter	Surfaceome	No	Yes	No	No	No
transporter	transporter	OmniPath	No	Yes	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometryWestern blotting	4	31508500 33709510 37922300 33709510

Sequence, Structure & Domains7

Sequences

Length

491

Mass

54,529

Sequence

MAGQGLPLHVATLLTGLLECLGFAGVLFGWPSLVFVFKNEDYFKDLCGPDAGPIGNATGQADCKAQDERFSLIFTLGSFMNNFMTFPTGYIFDRFKTTVARLIAIFFYTTATLIIAFTSAGSAVLLFLAMPMLTIGGILFLITNLQIGNLFGQHRSTIITLYNGAFDSSSAVFLIIKLLYEKGISLRASFIFISVCSTWHVARTFLLMPRGHIPYPLPPNYSYGLCPGNGTTKEEKETAEHENRELQSKEFLSAKEETPGAGQKQELRSFWSYAFSRRFAWHLVWLSVIQLWHYLFIGTLNSLLTNMAGGDMARVSTYTNAFAFTQFGVLCAPWNGLLMDRLKQKYQKEARKTGSSTLAVALCSTVPSLALTSLLCLGFALCASVPILPLQYLTFILQVISRSFLYGSNAAFLTLAFPSEHFGKLFGLVMALSAVVSLLQFPIFTLIKGSLQNDPFYVNVMFMLAILLTFFHPFLVYRECRTWKESPSAIA

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8NBI5-1; Sequence=Displayed; Name=2; IsoId=Q8NBI5-2; Sequence=VSP_055620

Alternative Sequence

61; A -> AGRLGCMGDLFSTP (in isoform 2)

Domain & Motif Annotations

Protein Families

SLC43A transporter (TC 2.A.1.44) family

Sequence Similarities

Belongs to the SLC43A transporter (TC 2.A.1.44) family.

Clinical Relevance4

Antibody (2)

HPA030551 HPA077244

Interaction Protein

ENSG00000165280

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications13

PMID	Title	Abstract
39558134	Serum small extracellular vesicles-derived BST2 as a biomarker for papillary thyroid microcarcinoma promotes lymph node metastasis.	No abstract available
39766158	A Proteomic Examination of Plasma Extracellular Vesicles Across Colorectal Cancer Stages Uncovers Biological Insights That Potentially Improve Prognosis.	No abstract available
39948040	Quantitative proteomics identifies possible flow of metastatic cues between progressive stages of colorectal cancer via transfer of ceramide-dependent exosomal cargoes.	No abstract available

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