Protein detail
SUMF2
Inactive C-alpha-formylglycine-generating enzyme 2 (Paralog of formylglycine-generating enzyme) (pFGE) (Sulfatase-modifying factor 2)
Entry name SUMF2 | UniProt ID | EVMP score 0.38 |
Frequency 4 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Inactive C-alpha-formylglycine-generating enzyme 2 (Paralog of formylglycine-generating enzyme) (pFGE) (Sulfatase-modifying factor 2)
Protein Class
Plasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
DKFZp566I1024
Gene Description
Sulfatase modifying factor 2
Chromosome
7
Position
56064002-56080670
Frequency
4
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificEsophageal apical cells
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-163841 gamma carboxylation hypusinylation hydroxylation and arylsulfatase activation
- R-hsa-9840310 glycosphingolipid catabolism
- R-hsa-1660662 glycosphingolipid metabolism
- R-hsa-556833 metabolism of lipids
- R-hsa-597592 post translational protein modification
- R-hsa-428157 sphingolipid metabolism
- R-hsa-1663150 the activation of arylsulfatases
Mediation Categories
Metabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass Spectrometry | 1 | 33709510 |
Sequence, Structure & Domains
Sequences
Length
301
Mass
33,843
Sequence
MARHGLPLLPLLSLLVGAWLKLGNGQATSMVQLQGGRFLMGTNSPDSRDGDGPVREATVKPFAIDIFPVTNKDFRDFVREKKYRTEAEMFGWSFVFEDFVSDELRNKATQPMKSVLWWLPVEKAFWRQPAGPGSGIRERLEHPVLHVSWNDARAYCAWRGKRLPTEEEWEFAARGGLKGQVYPWGNWFQPNRTNLWQGKFPKGDKAEDGFHGVSPVNAFPAQNNYGLYDLLGNVWEWTASPYQAAEQDMRVLRGASWIDTADGSANHRARVTTRMGNTPDSASDNLGFRCAADAGRPPGEL
Alternative Products
Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8NBJ7-1; Sequence=Displayed; Name=2; IsoId=Q8NBJ7-2; Sequence=VSP_007878; Name=3; IsoId=Q8NBJ7-3; Sequence=VSP_007879; Name=5; IsoId=Q8NBJ7-5; Sequence=VSP_040878; Name=4; IsoId=Q8NBJ7-4; Sequence=VSP_007880
Alternative Sequence
1..88; Missing (in isoform 2); 114..301; SVLWWLPVEKAFWRQPAGPGSGIRERLEHPVLHVSWNDARAYCAWRGKRLPTEEEWEFAARGGLKGQVYPWGNWFQPNRTNLWQGKFPKGDKAEDGFHGVSPVNAFPAQNNYGLYDLLGNVWEWTASPYQAAEQDMRVLRGASWIDTADGSANHRARVTTRMGNTPDSASDNLGFRCAADAGRPPGEL -> VKFTHGGTGSSQTAPTCGRESSPRETKLRMASMESPQMLSPPRTTTGSMTSWGTCGSGQHHRTRLLSRTCASSGGHPGSTQLMALPITGPGSPPGWATLQIQPQTTSVSAVLQTQAGRQGSCKQPGGDKEKSLLGSLSFPGHVANSAIPSSRASASGKNFPFPVSHPSVAGASHQGRRGLSLLCFGEGAQCVLTMAGGQVFLLEAKYY (in isoform 4); 114..197; Missing (in isoform 5); 227..301; LYDLLGNVWEWTASPYQAAEQDMRVLRGASWIDTADGSANHRARVTTRMGNTPDSASDNLGFRCAADAGRPPGEL -> WATLQIQPQTTSVSAVLQTQAGRQGSCKQPGGDKEKSLLGSLSFPGHVANSAIPSSRASASGKNFPFPVSHPSVAGASHQGRRGLSLLCFGEGAQCVLTMAGGQVFLLEAKYY (in isoform 3)
3D Structural Models
Turn
200..202
Helix
71..81; 86..90; 97..99; 102..106; 149..158; 166..174; 245..247
Beta Strand
30..33; 36..41; 55..59; 61..67; 92..96; 118..122; 185..187; 231..241; 250..254; 263..268; 274..277; 291..293
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
274..284; Polar residues
Motif
298..301; Non-canonical ER retention motif
Domain (CC)
The non-canonical ER retention motif mediates retention of the protein in the endoplasmic reticulum.
Region
274..301; Disordered
Protein Families
Sulfatase-modifying factor family
Sequence Similarities
Belongs to the sulfatase-modifying factor family.