Protein detail
SIDT2
SID1 transmembrane family member 2
Entry name SIDT2 | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 2 | Transmembrane count 10 | Protein classification Predicted intracellular proteinsPredicted membrane proteinsTransporters |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
SID1 transmembrane family member 2
Protein Class (3)
Predicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function (2)
- Transporters:Transporter channels and pores
- Predicted intracellular proteins
Transmembrane
297..317; Helical; 448..468; Helical; 500..520; Helical; 547..567; Helical; 606..626; Helical; 632..652; Helical; 689..709; Helical; 716..736; Helical; 747..767; Helical; 797..817; Helical
Transmembrane Count
10
Ensembl
Entrez Gene Symbol
Gene Synonym
CGI-40
Gene Description
SID1 transmembrane family member 2
Chromosome
11
Position
117178736-117197445
Supporting publications (n)
2
EVMP confidence score
0.40
Fluorescence & Localization
Cell SpecificEpicardial cells
Function & Pathway
Protein Function (2)
- Transporters:Transporter channels and pores
- Predicted intracellular proteins
Cellular Component (3)
Molecular Function (6)
Biological Process (3)
Mediation Categories (2)
Fusion and delivery mediationMetabolism mediation
Relations & Evidence19
Ligand-Receptor Signaling (18)
18 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | OmniPath | Yes | ||||
| intracellular | intracellular | ComPPI | Yes | ||||
| intracellular | intracellular | GO_Intercell | Yes | ||||
| intracellular | intracellular | UniProt_location | Yes | ||||
| intracellular | intracellular | OmniPath | Yes | ||||
| transmembrane | transmembrane | UniProt_location | Yes | ||||
| transmembrane | transmembrane | UniProt_topology | Yes | ||||
| transmembrane | transmembrane | UniProt_keyword | Yes | ||||
| transmembrane | transmembrane | TopDB | Yes | ||||
| transmembrane | transmembrane | Ramilowski_location | Yes |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass Spectrometry | 1 | 33709510 |
Sequence, Structure & Domains
Sequences
Length
832
Mass
94,454
Sequence
MFALGLPFLVLLVASVESHLGVLGPKNVSQKDAEFERTYVDEVNSELVNIYTFNHTVTRNRTEGVRVSVNVLNKQKGAPLLFVVRQKEAVVSFQVPLILRGMFQRKYLYQKVERTLCQPPTKNESEIQFFYVDVSTLSPVNTTYQLRVSRMDDFVLRTGEQFSFNTTAAQPQYFKYEFPEGVDSVIVKVTSNKAFPCSVISIQDVLCPVYDLDNNVAFIGMYQTMTKKAAITVQRKDFPSNSFYVVVVVKTEDQACGGSLPFYPFAEDEPVDQGHRQKTLSVLVSQAVTSEAYVSGMLFCLGIFLSFYLLTVLLACWENWRQKKKTLLVAIDRACPESGHPRVLADSFPGSSPYEGYNYGSFENVSGSTDGLVDSAGTGDLSYGYQGRSFEPVGTRPRVDSMSSVEEDDYDTLTDIDSDKNVIRTKQYLYVADLARKDKRVLRKKYQIYFWNIATIAVFYALPVVQLVITYQTVVNVTGNQDICYYNFLCAHPLGNLSAFNNILSNLGYILLGLLFLLIILQREINHNRALLRNDLCALECGIPKHFGLFYAMGTALMMEGLLSACYHVCPNYTNFQFDTSFMYMIAGLCMLKLYQKRHPDINASAYSAYACLAIVIFFSVLGVVFGKGNTAFWIVFSIIHIIATLLLSTQLYYMGRWKLDSGIFRRILHVLYTDCIRQCSGPLYVDRMVLLVMGNVINWSLAAYGLIMRPNDFASYLLAIGICNLLLYFAFYIIMKLRSGERIKLIPLLCIVCTSVVWGFALFFFFQGLSTWQKTPAESREHNRDCILLDFFDDHDIWHFLSSIAMFGSFLVLLTLDDDLDTVQRDKIYVF
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8NBJ9-1; Sequence=Displayed; Name=2; IsoId=Q8NBJ9-2; Sequence=VSP_013523, VSP_013524
Alternative Sequence
387; G -> GHDQFKRRLPSGQMRQLCIAMG (in isoform 2); 814..832; LLTLDDDLDTVQRDKIYVF -> SGPPGAALRIT (in isoform 2)
3D Structural Models
Turn
213..217; 488..490; 531..533; 537..540; 574..576; 626..628; 747..749; 790..792; 827..830
Helix
235..237; 254..256; 291..318; 451..478; 501..504; 507..530; 548..567; 577..580; 583..598; 603..625; 631..651; 686..709; 715..738; 750..768; 777..781; 795..816; 817..819
Beta Strand
27..32; 38..43; 47..58; 64..73; 76..78; 80..85; 90..100; 102..104; 106..115; 122..136; 142..151; 162..167; 168..170; 172..177; 184..190; 194..196; 198..203; 205..207; 218..234; 241..249; 267..269; 278..286; 482..484; 541..543; 769..772; 773..775
3D Structure
Electron microscopy (7)
Domain & Motif Annotations
Protein Families
SID1 family
Sequence Similarities
Belongs to the SID1 family.
Clinical Relevance
Antibody
Supporting Publications2
| PMID | Title | Related sentences |
|---|---|---|
| 31753726 | Serum extracellular vesicles contain SPARC and LRG1 as biomarkers of colon cancer and differ by tumour primary location. | No related sentences available |
| 38071653 | Extracellular vesicle proteome unveils cathepsin B connection to Alzheimer's disease pathogenesis. | Extracellular vesicle proteome unveils cathepsin B connection to Alzheimer's disease pathogenesis. |