Protein detail
TM87A
Transmembrane protein 87A (Elkin1)
Protein symbol TM87A | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 7 | Protein classification Predicted intracellular proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Transmembrane protein 87A (Elkin1)
Protein Class
Predicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Transporters
- Predicted intracellular proteins
Transmembrane
226..246; Helical; Name=1; 258..278; Helical; Name=2; 306..322; Helical; Name=3; 326..346; Helical; Name=4; 362..382; Helical; Name=5; 404..424; Helical; Name=6; 438..458; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
DKFZP564G2022
Gene Description
Transmembrane protein 87A
Chromosome
15
Position
42210447-42273534
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificAlveolar cells type 1Single-Nuclei Brain Specificeccentric medium spiny neuronBlood Cell SpecificneutrophilBlood Lineage SpecificB-cells
Function & Pathway
Protein Function
- Transporters
- Predicted intracellular proteins
Cellular Component
Biological Process
Reactome
Mediation Categories
Receptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
16 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | UniProt_location | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass Spectrometry | 1 | 33709510 |
Sequence, Structure & Domains
Sequences
Length
555
Mass
63,430
Sequence
MAAAAWLQVLPVILLLLGAHPSPLSFFSAGPATVAAADRSKWHIPIPSGKNYFSFGKILFRNTTIFLKFDGEPCDLSLNITWYLKSADCYNEIYNFKAEEVELYLEKLKEKRGLSGKYQTSSKLFQNCSELFKTQTFSGDFMHRLPLLGEKQEAKENGTNLTFIGDKTAMHEPLQTWQDAPYIFIVHIGISSSKESSKENSLSNLFTMTVEVKGPYEYLTLEDYPLMIFFMVMCIVYVLFGVLWLAWSACYWRDLLRIQFWIGAVIFLGMLEKAVFYAEFQNIRYKGESVQGALILAELLSAVKRSLARTLVIIVSLGYGIVKPRLGVTLHKVVVAGALYLLFSGMEGVLRVTGAQTDLASLAFIPLAFLDTALCWWIFISLTQTMKLLKLRRNIVKLSLYRHFTNTLILAVAASIVFIIWTTMKFRIVTCQSDWRELWVDDAIWRLLFSMILFVIMVLWRPSANNQRFAFSPLSEEEEEDEQKEPMLKESFEGMKMRSTKQEPNGNSKVNKAQEDDLKWVEENVPSSVTDVALPALLDSDEERMITHFERSKME
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8NBN3-1; Sequence=Displayed; Name=2; IsoId=Q8NBN3-2; Sequence=VSP_022208, VSP_022209; Name=3; IsoId=Q8NBN3-3; Sequence=VSP_022207
Alternative Sequence
1..69; MAAAAWLQVLPVILLLLGAHPSPLSFFSAGPATVAAADRSKWHIPIPSGKNYFSFGKILFRNTTIFLKF -> MAHSDTVV (in isoform 3); 169..181; AMHEPLQTWQDAP -> IQMPFLKKHFLDC (in isoform 2); 182..555; Missing (in isoform 2)
3D Structural Models
Turn
108..111; 134..136; 221..223; 291..293; 320..322; 331..334; 426..428; 466..469
Helix
91..94; 98..100; 101..107; 224..250; 258..286; 294..316; 327..330; 335..338; 339..352; 360..391; 396..425; 440..442; 444..459
Beta Strand
40..44; 46..48; 52..59; 64..72; 76..85; 118..127; 173..175; 177..191; 206..213; 215..218; 429..431
3D Structure
Electron microscopy (4)
Domain & Motif Annotations
Compositional Bias
484..496; Basic and acidic residues; 502..511; Polar residues
Region
473..516; Disordered
Protein Families
- LU7TM family
- TMEM87 subfamily
Sequence Similarities
Belongs to the LU7TM family. TMEM87 subfamily.