Protein detail
AQP11
Aquaporin-11 (AQP-11)
Protein symbol AQP11 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 6 | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Aquaporin-11 (AQP-11)
Protein Function
Transporters:Transporter channels and pores
Transmembrane
15..35; Helical; Name=1; 42..62; Helical; Name=2; 75..95; Helical; Name=3; 164..184; Helical; Name=4; 195..215; Helical; Name=5; 235..255; Helical; Name=6
Transmembrane Count
6
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificchoroid plexusCell SpecificChoroid plexus epithelial cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cell
Function & Pathway
Protein Function
Transporters:Transporter channels and pores
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
20 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ion_channel | ion_channel | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Western blottingMass spectrometryFACSWestern blotting|FACS|Mass spectrometryImmunoelectron MicroscopyMass spectrometry|Western blottingWestern blotting|FACSImmunoelectron microscopyMass spectrometry [LTQ-FT Ultra]|Western blottingMass spectrometry [QTOF]Flow cytometric alysis|Mass spectrometryFlow cytometryImmuno-EM | 1 | 23260141 |
Sequence, Structure & Domains
Sequences
Length
271
Mass
30,203
Sequence
MSPLLGLRSELQDTCTSLGLMLSVVLLMGLARVVARQQLHRPVAHAFVLEFLATFQLCCCTHELQLLSEQHPAHPTWTLTLVYFFSLVHGLTLVGTSSNPCGVMMQMMLGGMSPETGAVRLLAQLVSALCSRYCTSALWSLGLTQYHVSERSFACKNPIRVDLLKAVITEAVCSFLFHSALLHFQEVRTKLRIHLLAALITFLVYAGGSLTGAVFNPALALSLHFMCFDEAFPQFFIVYWLAPSLGILLMILMFSFFLPWLHNNHTINKKE
3D Structural Models
Domain & Motif Annotations
Motif
99..101; NPC; 216..218; NPA
Domain (CC)
The NPC motif is essential for oligomerization and water permeability function.
Protein Families
- MIP/aquaporin (TC 1.A.8) family
- AQP11/AQP12 subfamily
Sequence Similarities
Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.