Protein detail
CTL5
Choline transporter-like protein 5 (Solute carrier family 44 member 5)
Entry name CTL5 | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 1 | Transmembrane count 10 | Protein classification Metabolic proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Choline transporter-like protein 5 (Solute carrier family 44 member 5)
Protein Class (3)
Metabolic proteinsPredicted membrane proteinsTransporters
Protein Function
Transporters:Electrochemical Potential-driven transporters
Transmembrane
39..59; Helical; 243..263; Helical; 266..286; Helical; 326..346; Helical; 352..372; Helical; 375..395; Helical; 461..481; Helical; 516..536; Helical; 611..631; Helical; 650..670; Helical
Transmembrane Count
10
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
CTL5MGC34032
Gene Description
Solute carrier family 44 member 5
Chromosome
1
Position
75202129-75611114
Supporting publications (n)
1
EVMP confidence score
0.25
Fluorescence & Localization1
Cell SpecificEarly spermatids
Function & Pathway7
Protein Function
Transporters:Electrochemical Potential-driven transporters
Cellular Component (2)
Molecular Function (4)
Biological Process (3)
Reactome (8)
- R-hsa-1483206 glycerophospholipid biosynthesis
- R-hsa-556833 metabolism of lipids
- R-hsa-1483257 phospholipid metabolism
- R-hsa-9958517 slc mediated bile acid transport
- R-hsa-425407 slc mediated transmembrane transport
- R-hsa-9955298 slc mediated transport of organic anions
- R-hsa-1483191 synthesis of pc
- R-hsa-382551 transport of small molecules
Mediation Categories (2)
Fusion and delivery mediationMetabolism mediation
Relations & Evidence18
Ligand-Receptor Signaling (17)
17 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transporter | transporter | Surfaceome | No | Yes | No | No | No |
| solute_carrier | transporter | Almen2009 | No | Yes | No | No | No |
| slc44 | transporter | Surfaceome | No | Yes | No | No | No |
| slc | transporter | Surfaceome | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
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Isolation & Detection Technology (1)
Sequence, Structure & Domains8
Sequences
Length
719
Mass
81,694
Sequence
MNDTEKPADTPSEEEDFGDPRTYDPDFKGPVANRSCTDVLCCMIFLLCIIGYIVLGLVAWVHGDPRRAAYPTDSQGHFCGQKGTPNENKTILFYFNLLRCTSPSVLLNLQCPTTQICVSKCPEKFLTYVEMQLLYTKDKSYWEDYRQFCKTTAKPVKSLTQLLLDDDCPTAIFPSKPFLQRCFPDFSTKNGTLTIGSKMMFQDGNGGTRSVVELGIAANGINKLLDAKSLGLKVFEDYARTWYWILIGLTIAMVLSWIFLILLRFIAGCLFWVFMIGVIGIIGYGIWHCYQQYTNLQERPSSVLTIYDIGIQTNISMYFELQQTWFTFMIILCIIEVIVILMLIFLRNRIRVAIILLKEGSKAIGYVPSTLVYPALTFILLSICICYWVVTAVFLATSGVPVYKVIAPGGHCIHENQTCDPEIFNTTEIAKACPGALCNFAFYGGKSLYHQYIPTFHVYNLFVFLWLINFVIALGQCALAGAFATYYWAMKKPDDIPRYPLFTAFGRAIRYHTGSLAFGSLIIALIQMFKIVLEYLDHRLKRTQNTLSKFLQCCLRCCFWCLENAIKFLNRNAYIMIAIYGRNFCRSAKDAFNLLMRNVLKVAVTDEVTYFVLFLGKLLVAGSIGVLAFLFFTQRLPVIAQGPASLNYYWVPLLTVIFGSYLIAHGFFSVYAMCVETIFICFCEDLERNDGSTEKPYFVTPNLHGILIKKQLVPQKQKE
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=A; IsoId=Q8NCS7-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q8NCS7-4; Sequence=VSP_059803; Name=3; IsoId=Q8NCS7-5; Sequence=VSP_059802, VSP_059803
Alternative Sequence
1..42; Missing (in isoform 3); 683..719; CEDLERNDGSTEKPYFVTPNLHGILIKKQLVPQKQKE -> LEDLERNDGSTARPYYVSQPLLKIFQEENPQTRKQ (in isoform 2 and isoform 3)
Domain & Motif Annotations
Region
1..24; Disordered
Protein Families
CTL (choline transporter-like) family
Sequence Similarities
Belongs to the CTL (choline transporter-like) family.
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 30550287 | Label-Free Proteomic Analysis of Exosomes Secreted from THP-1-Derived Macrophages Treated with IFN-α Identifies Antiviral Proteins Enriched in Exosomes. | No abstract available |