Protein detail
GLT11
Polypeptide N-acetylgalactosaminyltransferase 11 (EC 2.4.1.41) (Polypeptide GalNAc transferase 11) (GalNAc-T11) (pp-GaNTase 11) (Protein-UDP acetylgalactosaminyltransferase 11) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11)
Entry name GLT11 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification Disease related genesEnzymesMetabolic proteinsPotential drug targetsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Polypeptide N-acetylgalactosaminyltransferase 11 (EC 2.4.1.41) (Polypeptide GalNAc transferase 11) (GalNAc-T11) (pp-GaNTase 11) (Protein-UDP acetylgalactosaminyltransferase 11) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11)
Protein Class (5)
Disease related genesEnzymesMetabolic proteinsPotential drug targetsPredicted membrane proteins
Protein Function (4)
- ENZYME proteins:Transferases
- Disease related genes
- Enzymes
- Potential drug targets
Transmembrane
7..29; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
GalNAc-T11
Gene Description
Polypeptide N-acetylgalactosaminyltransferase 11
Chromosome
7
Position
152025674-152122340
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization3
Cell SpecificGonadotrophsBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes
Function & Pathway7
Protein Function (4)
- ENZYME proteins:Transferases
- Disease related genes
- Enzymes
- Potential drug targets
Cellular Component (2)
Molecular Function (5)
Biological Process (3)
KEGG (3)
Reactome (3)
Mediation Categories
Metabolism mediation
Relations & Evidence14
Ligand-Receptor Signaling (13)
13 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
| transmembrane_phobius | transmembrane_predicted | Almen2009 | No | No | No | No | No |
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 | No | No | No | No | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | R Sequencing | 1 | 33709510 |
Sequence, Structure & Domains10
Sequences
Length
608
Mass
68,919
Sequence
MGSVTVRYFCYGCLFTSATWTVLLFVYFNFSEVTQPLKNVPVKGSGPHGPSPKKFYPRFTRGPSRVLEPQFKANKIDDVIDSRVEDPEEGHLKFSSELGMIFNERDQELRDLGYQKHAFNMLISDRLGYHRDVPDTRNAACKEKFYPPDLPAASVVICFYNEAFSALLRTVHSVIDRTPAHLLHEIILVDDDSDFDDLKGELDEYVQKYLPGKIKVIRNTKREGLIRGRMIGAAHATGEVLVFLDSHCEVNVMWLQPLLAAIREDRHTVVCPVIDIISADTLAYSSSPVVRGGFNWGLHFKWDLVPLSELGRAEGATAPIKSPTMAGGLFAMNRQYFHELGQYDSGMDIWGGENLEISFRIWMCGGKLFIIPCSRVGHIFRKRRPYGSPEGQDTMTHNSLRLAHVWLDEYKEQYFSLRPDLKTKSYGNISERVELRKKLGCKSFKWYLDNVYPEMQISGSHAKPQQPIFVNRGPKRPKVLQRGRLYHLQTNKCLVAQGRPSQKGGLVVLKACDYSDPNQIWIYNEEHELVLNSLLCLDMSETRSSDPPRLMKCHGSGGSQQWTFGKNNRLYQVSVGQCLRAVDPLGQKGSVAMAICDGSSSQQWHLEG
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8NCW6-1; Sequence=Displayed; Name=2; IsoId=Q8NCW6-2; Sequence=VSP_011215, VSP_011216
Alternative Sequence
196..202; DDLKGEL -> GKECCTW (in isoform 2); 203..608; Missing (in isoform 2)
Domain & Motif Annotations
Domain (CC)
There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.; DOMAIN: The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
Domain (FT)
476..607; Ricin B-type lectin
Region
150..261; Catalytic subdomain A; 319..381; Catalytic subdomain B
Protein Families (2)
- Glycosyltransferase 2 family
- GalNAc-T subfamily
Sequence Similarities
Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 27605433 | Secreted primary human malignant mesothelioma exosome signature reflects oncogenic cargo. | No abstract available |