Protein detail
BANK1
B-cell scaffold protein with ankyrin repeats
Entry name BANK1 | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 3 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
B-cell scaffold protein with ankyrin repeats
Protein Class (3)
Disease related genesHuman disease related genesPredicted intracellular proteins
Protein Function (4)
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- Disease related genes
- Human disease related genes:Skin diseases:Skin and soft tissue diseases
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
BANKFLJ20706
Gene Description
B cell scaffold protein with ankyrin repeats 1
Chromosome
4
Position
101411286-102074812
Supporting publications (n)
3
EVMP confidence score
0.40
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificCardiomyocytesBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function (4)
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- Disease related genes
- Human disease related genes:Skin diseases:Skin and soft tissue diseases
- Predicted intracellular proteins
Cellular Component
Molecular Function (6)
Biological Process (3)
Canonical Pathways (2)
- M77 Pid wnt signaling pathway
- M23 Pid wnt noncanonical pathway
Mediation Categories (2)
Immune mediationReceptor-signaling mediation
Relations & Evidence6
Enzyme-Mediated Modification (2)
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| BANK1 | BLK | P51451 | Y | 146 | phosphorylation | RLIMS-P_ProtMapperProtMapper | ProtMapper:23555801 |
| BANK1 | BLK | P51451 | Y | 484 | phosphorylation | RLIMS-P_ProtMapperProtMapper | ProtMapper:23555801 |
Ligand-Receptor Signaling (3)
3 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | OmniPath |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationImmunoaffinity Capture | R SequencingMass spectrometry | 1 | 22285593 |
Sequence, Structure & Domains
Sequences
Length
785
Mass
89,282
Sequence
MLPAAPGKGLGSPDPAPCGPAPPGNTKDIIMIYEEDAEEWALYLTEVFLHVVKREAILLYRLENFSFRHLELLNLTSYKCKLLILSNSLLRDLTPKKCQFLEKILHSPKSVVTLLCGVKSSDQLYELLNISQSRWEISTEQEPEDYISVIQSIIFKDSEDYFEVNIPTDLRAKHSGEISERKEIEELSEASRNTIPLAVVLPTEIPCENPGEIFIILRDEVIGDTVEVEFTSSNKRIRTRPALWNKKVWCMKALEFPAGSVHVNVYCDGIVKATTKIKYYPTAKAKECLFRMADSGESLCQNSIEELDGVLTSIFKHEIPYYEFQSLQTEICSQNKYTHFKELPTLLHCAAKFGLKNLAIHLLQCSGATWASKMKNMEGSDPAHIAERHGHKELKKIFEDFSIQEIDINNEQENDYEEDIASFSTYIPSTQNPAFHHESRKTYGQSADGAEANEMEGEGKQNGSGMETKHSPLEVGSESSEDQYDDLYVFIPGADPENNSQEPLMSSRPPLPPPRPVANAFQLERPHFTLPGTMVEGQMERSQNWGHPGVRQETGDEPKGEKEKKEEEKEQEEEEDPYTFAEIDDSEYDMILANLSIKKKTGSRSFIINRPPAPTPRPTSIPPKEETTPYIAQVFQQKTARRQSDDDKFCGLPKKQDRARIESPAFSTLRGCLTDGQEELILLQEKVKNGKMSMDEALEKFKHWQMGKSGLEMIQQEKLRQLRDCIIGKRPEEENVYNKLTIVHHPGGKETAHNENKFYNVHFSNKLPARPQVEKEFGFCCKKDH
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8NDB2-1; Sequence=Displayed; Name=2; IsoId=Q8NDB2-2; Sequence=VSP_020804, VSP_020805; Name=3; IsoId=Q8NDB2-3; Sequence=VSP_020803; Name=4; Synonyms=delta2; IsoId=Q8NDB2-4; Sequence=VSP_034214
Alternative Sequence
1..30; Missing (in isoform 3); 1..14; Missing (in isoform 2); 15..23; PAPCGPAPP -> MVNCHLKI (in isoform 2); 24..156; Missing (in isoform 4)
Domain & Motif Annotations
Compositional Bias
553..568; Basic and acidic residues; 569..578; Acidic residues; 611..621; Pro residues
Repeat
342..371; ANK 1; 378..408; ANK 2
Domain (FT)
25..153; TIR; 200..327; DBB
Region
1..154; Interaction with ITPR2; 433..480; Disordered; 493..514; Disordered; 538..578; Disordered; 606..625; Disordered
Clinical Relevance
Disease Involvement
Systemic lupus erythematosus
Related Diseases
Antibody
Interaction Protein
ENSG00000254087
Interaction Count
1
Interaction Dataset
intact_biogrid
Supporting Publications3
| PMID | Title | Related sentences |
|---|---|---|
| 33709510 | Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection. | No related sentences available |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No related sentences available |
| 40098346 | Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays. | No related sentences available |