Protein detail

BANK1

B-cell scaffold protein with ankyrin repeats

Entry name BANK1	UniProt ID Q8NDB2	EVMP confidence score 0.38
Supporting publications (n) 3	Transmembrane count	Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

B-cell scaffold protein with ankyrin repeats

Protein Class (3)

Disease related genesHuman disease related genesPredicted intracellular proteins

Protein Function (4)

Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
Disease related genes
Human disease related genes:Skin diseases:Skin and soft tissue diseases
Predicted intracellular proteins

Ensembl

ENSG00000153064

Entrez Gene Symbol

BANK1

Gene Synonym (2)

BANKFLJ20706

Gene Description

B cell scaffold protein with ankyrin repeats 1

Chromosome

Position

101411286-102074812

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization5

Tissue Specificbone marrowCell SpecificCardiomyocytesBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes

Function & Pathway7

Protein Function (4)

Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
Disease related genes
Human disease related genes:Skin diseases:Skin and soft tissue diseases
Predicted intracellular proteins

Cellular Component

GO:0048471 perinuclear region of cytoplasm

Molecular Function (6)

Biological Process (3)

KEGG

hsa04662 B cell receptor signaling pathway

Canonical Pathways (2)

M77 Pid wnt signaling pathway
M23 Pid wnt noncanonical pathway

Mediation Categories (2)

Immune mediationReceptor-signaling mediation

Relations & Evidence6

Enzyme-Mediated Modification (2)

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
BANK1	BLK	P51451	Y	146	phosphorylation	RLIMS-P_ProtMapperProtMapper	ProtMapper:23555801
BANK1	BLK	P51451	Y	484	phosphorylation	RLIMS-P_ProtMapperProtMapper	ProtMapper:23555801

Ligand-Receptor Signaling (3)

3 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationImmunoaffinity Capture	R SequencingMass spectrometry	1	22285593

Sequence, Structure & Domains9

Sequences

Length

785

Mass

89,282

Sequence

MLPAAPGKGLGSPDPAPCGPAPPGNTKDIIMIYEEDAEEWALYLTEVFLHVVKREAILLYRLENFSFRHLELLNLTSYKCKLLILSNSLLRDLTPKKCQFLEKILHSPKSVVTLLCGVKSSDQLYELLNISQSRWEISTEQEPEDYISVIQSIIFKDSEDYFEVNIPTDLRAKHSGEISERKEIEELSEASRNTIPLAVVLPTEIPCENPGEIFIILRDEVIGDTVEVEFTSSNKRIRTRPALWNKKVWCMKALEFPAGSVHVNVYCDGIVKATTKIKYYPTAKAKECLFRMADSGESLCQNSIEELDGVLTSIFKHEIPYYEFQSLQTEICSQNKYTHFKELPTLLHCAAKFGLKNLAIHLLQCSGATWASKMKNMEGSDPAHIAERHGHKELKKIFEDFSIQEIDINNEQENDYEEDIASFSTYIPSTQNPAFHHESRKTYGQSADGAEANEMEGEGKQNGSGMETKHSPLEVGSESSEDQYDDLYVFIPGADPENNSQEPLMSSRPPLPPPRPVANAFQLERPHFTLPGTMVEGQMERSQNWGHPGVRQETGDEPKGEKEKKEEEKEQEEEEDPYTFAEIDDSEYDMILANLSIKKKTGSRSFIINRPPAPTPRPTSIPPKEETTPYIAQVFQQKTARRQSDDDKFCGLPKKQDRARIESPAFSTLRGCLTDGQEELILLQEKVKNGKMSMDEALEKFKHWQMGKSGLEMIQQEKLRQLRDCIIGKRPEEENVYNKLTIVHHPGGKETAHNENKFYNVHFSNKLPARPQVEKEFGFCCKKDH

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8NDB2-1; Sequence=Displayed; Name=2; IsoId=Q8NDB2-2; Sequence=VSP_020804, VSP_020805; Name=3; IsoId=Q8NDB2-3; Sequence=VSP_020803; Name=4; Synonyms=delta2; IsoId=Q8NDB2-4; Sequence=VSP_034214

Alternative Sequence

1..30; Missing (in isoform 3); 1..14; Missing (in isoform 2); 15..23; PAPCGPAPP -> MVNCHLKI (in isoform 2); 24..156; Missing (in isoform 4)

Domain & Motif Annotations

Compositional Bias

553..568; Basic and acidic residues; 569..578; Acidic residues; 611..621; Pro residues

Repeat

342..371; ANK 1; 378..408; ANK 2

Domain (FT)

25..153; TIR; 200..327; DBB

Region

1..154; Interaction with ITPR2; 433..480; Disordered; 493..514; Disordered; 538..578; Disordered; 606..625; Disordered

Clinical Relevance5

Disease Involvement

Systemic lupus erythematosus

Antibody

HPA037002

Interaction Protein

ENSG00000254087

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications3

PMID	Title	Abstract
33709510	Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.	No abstract available
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No abstract available