Protein detail

EHBP1

EH domain-binding protein 1

Entry name EHBP1	UniProt ID Q8NDI1	EVMP confidence score 0.50
Supporting publications (n) 5	Transmembrane count	Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

EH domain-binding protein 1

Protein Class (4)

Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

Protein Function (3)

Disease related genes
Human disease related genes:Cancers:Cancers of male genital organs
Predicted intracellular proteins

Ensembl

ENSG00000115504

Entrez Gene Symbol

EHBP1

Gene Synonym (2)

KIAA0903NACSIN

Gene Description

EH domain binding protein 1

Chromosome

Position

62673851-63046487

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization4

Tissue SpecifictestisCell SpecificAstrocytesBlood Cell Specificeosinophil

Function & Pathway4

Protein Function (3)

Disease related genes
Human disease related genes:Cancers:Cancers of male genital organs
Predicted intracellular proteins

Cellular Component (4)

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence8

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (3)

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
ANTXR2 EHBP1 HOMER1 HOMER2 HOMER3 IFT57 SPAG5 SPTBN4 TRAF5	O00463 P58335 Q86YM7 Q8NDI1 Q96R06 Q9H254 Q9NSB8 Q9NSC5 Q9NWB7	0:0:0:0:0:0:0:0:0	hu.MAP2
EHBP1 HOMER1 HOMER2 HOMER3 IFT57 SPAG5	Q86YM7 Q8NDI1 Q96R06 Q9NSB8 Q9NSC5 Q9NWB7	0:0:0:0:0:0	hu.MAP2
EHBP1	Q8NDI1	4	PDB	PDB:6zsh

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	2	33709510 29148239

Sequence, Structure & Domains15

Sequences

Length

1,231

Mass

140,017

Sequence

MASVWKRLQRVGKHASKFQFVASYQELMVECTKKWQPDKLVVVWTRRSRRKSSKAHSWQPGIKNPYRGVVVWPVPENIEITVTLFKDPHAEEFEDKEWTFVIENESPSGRRKALATSSINMKQYASPMPTQTDVKLKFKPLSKKVVSAALQFSLSCIFLREGKATDEDMQSLASLMSMKQADIGNLDDFEEDNEDDDENRVNQEEKAAKITEIVNQLNALSSLDEDQDDCIKQANMRSAKSASSSEELINKLNFLDEAEKDLATVNSNPFDDPDAAELNPFGDPDSEEPITETASPRKTEDSFYNNSYNPFKEVQTPQYLNPFDEPEAFVTIKDSPPQSTKRKNIRPVDMSKYLYADSSKTEEEELDESNPFYEPKSTPPPNNLVNPVQELETERRVKRKAPAPPVLSPKTGVLNENTVSAGKDLSTSPKPSPIPSPVLGRKPNASQSLLVWCKEVTKNYRGVKITNFTTSWRNGLSFCAILHHFRPDLIDYKSLNPQDIKENNKKAYDGFASIGISRLLEPSDMVLLAIPDKLTVMTYLYQIRAHFSGQELNVVQIEENSSKSTYKVGNYETDTNSSVDQEKFYAELSDLKREPELQQPISGAVDFLSQDDSVFVNDSGVGESESEHQTPDDHLSPSTASPYCRRTKSDTEPQKSQQSSGRTSGSDDPGICSNTDSTQAQVLLGKKRLLKAETLELSDLYVSDKKKDMSPPFICEETDEQKLQTLDIGSNLEKEKLENSRSLECRSDPESPIKKTSLSPTSKLGYSYSRDLDLAKKKHASLRQTESDPDADRTTLNHADHSSKIVQHRLLSRQEELKERARVLLEQARRDAALKAGNKHNTNTATPFCNRQLSDQQDEERRRQLRERARQLIAEARSGVKMSELPSYGEMAAEKLKERSKASGDENDNIEIDTNEEIPEGFVVGGGDELTNLENDLDTPEQNSKLVDLKLKKLLEVQPQVANSPSSAAQKAVTESSEQDMKSGTEDLRTERLQKTTERFRNPVVFSKDSTVRKTQLQSFSQYIENRPEMKRQRSIQEDTKKGNEEKAAITETQRKPSEDEVLNKGFKDTSQYVVGELAALENEQKQIDTRAALVEKRLRYLMDTGRNTEEEEAMMQEWFMLVNKKNALIRRMNQLSLLEKEHDLERRYELLNRELRAMLAIEDWQKTEAQKRREQLLLDELVALVNKRDALVRDLDAQEKQAEEEDEHLERTLEQNKGKMAKKEEKCVLQ

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8NDI1-1; Sequence=Displayed; Name=2; IsoId=Q8NDI1-2; Sequence=VSP_024834; Name=3; IsoId=Q8NDI1-3; Sequence=VSP_024834, VSP_024835

Alternative Sequence

212..246; Missing (in isoform 2 and isoform 3); 905..940; Missing (in isoform 3)

3D Structural Models

Turn

457..459; 1199..1201

Helix

445..456; 470..472; 476..485; 487..489; 492..494; 500..513; 522..528; 533..547; 1076..1101; 1110..1160; 1164..1166; 1169..1198

Beta Strand

466..469

3D Structure

NMR spectroscopy (1); X-ray crystallography (3)

Domain & Motif Annotations

Compositional Bias

302..318; Polar residues; 625..635; Basic and acidic residues; 654..675; Polar residues; 737..753; Basic and acidic residues; 754..764; Polar residues; 790..800; Basic and acidic residues; 839..849; Polar residues; 895..904; Basic and acidic residues; 905..919; Acidic residues; 960..976; Polar residues; 979..996; Basic and acidic residues; 1026..1065; Basic and acidic residues; 1209..1231; Basic and acidic residues

Motif

1228..1231; CAAX motif

Coiled Coil

185..210; 808..879; 1076..1100; 1136..1230

Domain (CC)

The CAAX motif is a signal for prenylation and required for endosomal colocalization with Rab8 and Rab10..; DOMAIN: The bivalent Mical/EHBP Rab binding (bMERB) domain, mediates binding to Rab8, Rab10, Rab10, Rab13 and Rab15 (in their GTP-bound forms).

Domain (FT)

8..158; C2 NT-type; 443..548; Calponin-homology (CH); 1056..1212; bMERB

Region

264..318; Disordered; 358..440; Disordered; 616..675; Disordered; 737..764; Disordered; 777..800; Disordered; 837..865; Disordered; 895..941; Disordered; 960..996; Disordered; 1025..1065; Disordered; 1198..1231; Disordered

Clinical Relevance1

Antibody (2)

HPA035468 HPA035469

Supporting Publications5

PMID	Title	Abstract
27894104	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	No abstract available
33204424	Proteomic analysis of extracellular vesicles reveals an immunogenic cargo in rheumatoid arthritis synovial fluid.	No abstract available
38321535	Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles.	No abstract available
39505756	Differential proteomic profiles of exosomes in pediatric and adult adamantinomatous craniopharyngioma cyst fluid.	No abstract available
40089067	Metabolic Reprogramming Into a Glycolysis Phenotype Induced by Extracellular Vesicles Derived From Prostate Cancer Cells.	No abstract available