Protein detail

EHBP1

EH domain-binding protein 1

Protein symbol EHBP1	UniProt ID Q8NDI1	EVMP score 0.50
Frequency 5	Transmembrane count	Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

Basic Information

Protein Names

EH domain-binding protein 1

Protein Class

Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

Protein Function

Disease related genes
Human disease related genes:Cancers:Cancers of male genital organs
Predicted intracellular proteins

Ensembl

ENSG00000115504

Entrez Gene Symbol

EHBP1

Gene Synonym

KIAA0903NACSIN

Gene Description

EH domain binding protein 1

Chromosome

Position

62673851-63046487

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue SpecifictestisCell SpecificAstrocytesBlood Cell Specificeosinophil

Function & Pathway

Protein Function

Disease related genes
Human disease related genes:Cancers:Cancers of male genital organs
Predicted intracellular proteins

Cellular Component

Biological Process

Mediation Categories

Other mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
ANTXR2 EHBP1 HOMER1 HOMER2 HOMER3 IFT57 SPAG5 SPTBN4 TRAF5	O00463 P58335 Q86YM7 Q8NDI1 Q96R06 Q9H254 Q9NSB8 Q9NSC5 Q9NWB7	0:0:0:0:0:0:0:0:0	hu.MAP2
EHBP1 HOMER1 HOMER2 HOMER3 IFT57 SPAG5	Q86YM7 Q8NDI1 Q96R06 Q9NSB8 Q9NSC5 Q9NWB7	0:0:0:0:0:0	hu.MAP2
EHBP1	Q8NDI1	4	PDB	PDB:6zsh

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	2	33709510 29148239

Sequence, Structure & Domains

Sequences

Length

1,231

Mass

140,017

Sequence

MASVWKRLQRVGKHASKFQFVASYQELMVECTKKWQPDKLVVVWTRRSRRKSSKAHSWQPGIKNPYRGVVVWPVPENIEITVTLFKDPHAEEFEDKEWTFVIENESPSGRRKALATSSINMKQYASPMPTQTDVKLKFKPLSKKVVSAALQFSLSCIFLREGKATDEDMQSLASLMSMKQADIGNLDDFEEDNEDDDENRVNQEEKAAKITEIVNQLNALSSLDEDQDDCIKQANMRSAKSASSSEELINKLNFLDEAEKDLATVNSNPFDDPDAAELNPFGDPDSEEPITETASPRKTEDSFYNNSYNPFKEVQTPQYLNPFDEPEAFVTIKDSPPQSTKRKNIRPVDMSKYLYADSSKTEEEELDESNPFYEPKSTPPPNNLVNPVQELETERRVKRKAPAPPVLSPKTGVLNENTVSAGKDLSTSPKPSPIPSPVLGRKPNASQSLLVWCKEVTKNYRGVKITNFTTSWRNGLSFCAILHHFRPDLIDYKSLNPQDIKENNKKAYDGFASIGISRLLEPSDMVLLAIPDKLTVMTYLYQIRAHFSGQELNVVQIEENSSKSTYKVGNYETDTNSSVDQEKFYAELSDLKREPELQQPISGAVDFLSQDDSVFVNDSGVGESESEHQTPDDHLSPSTASPYCRRTKSDTEPQKSQQSSGRTSGSDDPGICSNTDSTQAQVLLGKKRLLKAETLELSDLYVSDKKKDMSPPFICEETDEQKLQTLDIGSNLEKEKLENSRSLECRSDPESPIKKTSLSPTSKLGYSYSRDLDLAKKKHASLRQTESDPDADRTTLNHADHSSKIVQHRLLSRQEELKERARVLLEQARRDAALKAGNKHNTNTATPFCNRQLSDQQDEERRRQLRERARQLIAEARSGVKMSELPSYGEMAAEKLKERSKASGDENDNIEIDTNEEIPEGFVVGGGDELTNLENDLDTPEQNSKLVDLKLKKLLEVQPQVANSPSSAAQKAVTESSEQDMKSGTEDLRTERLQKTTERFRNPVVFSKDSTVRKTQLQSFSQYIENRPEMKRQRSIQEDTKKGNEEKAAITETQRKPSEDEVLNKGFKDTSQYVVGELAALENEQKQIDTRAALVEKRLRYLMDTGRNTEEEEAMMQEWFMLVNKKNALIRRMNQLSLLEKEHDLERRYELLNRELRAMLAIEDWQKTEAQKRREQLLLDELVALVNKRDALVRDLDAQEKQAEEEDEHLERTLEQNKGKMAKKEEKCVLQ

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8NDI1-1; Sequence=Displayed; Name=2; IsoId=Q8NDI1-2; Sequence=VSP_024834; Name=3; IsoId=Q8NDI1-3; Sequence=VSP_024834, VSP_024835

Alternative Sequence

212..246; Missing (in isoform 2 and isoform 3); 905..940; Missing (in isoform 3)

3D Structural Models

Turn

457..459; 1199..1201

Helix

445..456; 470..472; 476..485; 487..489; 492..494; 500..513; 522..528; 533..547; 1076..1101; 1110..1160; 1164..1166; 1169..1198

Beta Strand

466..469

3D Structure

NMR spectroscopy (1); X-ray crystallography (3)

Domain & Motif Annotations

Compositional Bias

302..318; Polar residues; 625..635; Basic and acidic residues; 654..675; Polar residues; 737..753; Basic and acidic residues; 754..764; Polar residues; 790..800; Basic and acidic residues; 839..849; Polar residues; 895..904; Basic and acidic residues; 905..919; Acidic residues; 960..976; Polar residues; 979..996; Basic and acidic residues; 1026..1065; Basic and acidic residues; 1209..1231; Basic and acidic residues

Motif

1228..1231; CAAX motif

Coiled Coil

185..210; 808..879; 1076..1100; 1136..1230

Domain (CC)

The CAAX motif is a signal for prenylation and required for endosomal colocalization with Rab8 and Rab10..; DOMAIN: The bivalent Mical/EHBP Rab binding (bMERB) domain, mediates binding to Rab8, Rab10, Rab10, Rab13 and Rab15 (in their GTP-bound forms).

Domain (FT)

8..158; C2 NT-type; 443..548; Calponin-homology (CH); 1056..1212; bMERB

Region

264..318; Disordered; 358..440; Disordered; 616..675; Disordered; 737..764; Disordered; 777..800; Disordered; 837..865; Disordered; 895..941; Disordered; 960..996; Disordered; 1025..1065; Disordered; 1198..1231; Disordered

Clinical Relevance

Antibody

HPA035468 HPA035469