Protein detail
EHBP1
EH domain-binding protein 1
Entry name EHBP1 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 5 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
EH domain-binding protein 1
Protein Class (4)
Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins
Protein Function (3)
- Disease related genes
- Human disease related genes:Cancers:Cancers of male genital organs
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
KIAA0903NACSIN
Gene Description
EH domain binding protein 1
Chromosome
2
Position
62673851-63046487
Supporting publications (n)
5
EVMP confidence score
0.53
Fluorescence & Localization
Tissue SpecifictestisCell SpecificAstrocytesBlood Cell Specificeosinophil
Function & Pathway
Protein Function (3)
- Disease related genes
- Human disease related genes:Cancers:Cancers of male genital organs
- Predicted intracellular proteins
Cellular Component (4)
Biological Process (3)
Mediation Categories
Other mediation
Relations & Evidence8
Ligand-Receptor Signaling (4)
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath |
Protein Complex Composition (3)
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ANTXR2EHBP1HOMER1HOMER2HOMER3IFT57SPAG5SPTBN4TRAF5 | O00463P58335Q86YM7Q8NDI1Q96R06Q9H254Q9NSB8Q9NSC5Q9NWB7 | 0:0:0:0:0:0:0:0:0 | hu.MAP2 | |||
| EHBP1HOMER1HOMER2HOMER3IFT57SPAG5 | Q86YM7Q8NDI1Q96R06Q9NSB8Q9NSC5Q9NWB7 | 0:0:0:0:0:0 | hu.MAP2 | |||
| EHBP1 | Q8NDI1 | 4 | PDB | PDB:6zsh |
Sequence, Structure & Domains
Sequences
Length
1,231
Mass
140,017
Sequence
MASVWKRLQRVGKHASKFQFVASYQELMVECTKKWQPDKLVVVWTRRSRRKSSKAHSWQPGIKNPYRGVVVWPVPENIEITVTLFKDPHAEEFEDKEWTFVIENESPSGRRKALATSSINMKQYASPMPTQTDVKLKFKPLSKKVVSAALQFSLSCIFLREGKATDEDMQSLASLMSMKQADIGNLDDFEEDNEDDDENRVNQEEKAAKITEIVNQLNALSSLDEDQDDCIKQANMRSAKSASSSEELINKLNFLDEAEKDLATVNSNPFDDPDAAELNPFGDPDSEEPITETASPRKTEDSFYNNSYNPFKEVQTPQYLNPFDEPEAFVTIKDSPPQSTKRKNIRPVDMSKYLYADSSKTEEEELDESNPFYEPKSTPPPNNLVNPVQELETERRVKRKAPAPPVLSPKTGVLNENTVSAGKDLSTSPKPSPIPSPVLGRKPNASQSLLVWCKEVTKNYRGVKITNFTTSWRNGLSFCAILHHFRPDLIDYKSLNPQDIKENNKKAYDGFASIGISRLLEPSDMVLLAIPDKLTVMTYLYQIRAHFSGQELNVVQIEENSSKSTYKVGNYETDTNSSVDQEKFYAELSDLKREPELQQPISGAVDFLSQDDSVFVNDSGVGESESEHQTPDDHLSPSTASPYCRRTKSDTEPQKSQQSSGRTSGSDDPGICSNTDSTQAQVLLGKKRLLKAETLELSDLYVSDKKKDMSPPFICEETDEQKLQTLDIGSNLEKEKLENSRSLECRSDPESPIKKTSLSPTSKLGYSYSRDLDLAKKKHASLRQTESDPDADRTTLNHADHSSKIVQHRLLSRQEELKERARVLLEQARRDAALKAGNKHNTNTATPFCNRQLSDQQDEERRRQLRERARQLIAEARSGVKMSELPSYGEMAAEKLKERSKASGDENDNIEIDTNEEIPEGFVVGGGDELTNLENDLDTPEQNSKLVDLKLKKLLEVQPQVANSPSSAAQKAVTESSEQDMKSGTEDLRTERLQKTTERFRNPVVFSKDSTVRKTQLQSFSQYIENRPEMKRQRSIQEDTKKGNEEKAAITETQRKPSEDEVLNKGFKDTSQYVVGELAALENEQKQIDTRAALVEKRLRYLMDTGRNTEEEEAMMQEWFMLVNKKNALIRRMNQLSLLEKEHDLERRYELLNRELRAMLAIEDWQKTEAQKRREQLLLDELVALVNKRDALVRDLDAQEKQAEEEDEHLERTLEQNKGKMAKKEEKCVLQ
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8NDI1-1; Sequence=Displayed; Name=2; IsoId=Q8NDI1-2; Sequence=VSP_024834; Name=3; IsoId=Q8NDI1-3; Sequence=VSP_024834, VSP_024835
Alternative Sequence
212..246; Missing (in isoform 2 and isoform 3); 905..940; Missing (in isoform 3)
3D Structural Models
Turn
457..459; 1199..1201
Helix
445..456; 470..472; 476..485; 487..489; 492..494; 500..513; 522..528; 533..547; 1076..1101; 1110..1160; 1164..1166; 1169..1198
Beta Strand
466..469
3D Structure
NMR spectroscopy (1); X-ray crystallography (3)
Domain & Motif Annotations
Compositional Bias
302..318; Polar residues; 625..635; Basic and acidic residues; 654..675; Polar residues; 737..753; Basic and acidic residues; 754..764; Polar residues; 790..800; Basic and acidic residues; 839..849; Polar residues; 895..904; Basic and acidic residues; 905..919; Acidic residues; 960..976; Polar residues; 979..996; Basic and acidic residues; 1026..1065; Basic and acidic residues; 1209..1231; Basic and acidic residues
Motif
1228..1231; CAAX motif
Coiled Coil
185..210; 808..879; 1076..1100; 1136..1230
Domain (CC)
The CAAX motif is a signal for prenylation and required for endosomal colocalization with Rab8 and Rab10..; DOMAIN: The bivalent Mical/EHBP Rab binding (bMERB) domain, mediates binding to Rab8, Rab10, Rab10, Rab13 and Rab15 (in their GTP-bound forms).
Domain (FT)
8..158; C2 NT-type; 443..548; Calponin-homology (CH); 1056..1212; bMERB
Region
264..318; Disordered; 358..440; Disordered; 616..675; Disordered; 737..764; Disordered; 777..800; Disordered; 837..865; Disordered; 895..941; Disordered; 960..996; Disordered; 1025..1065; Disordered; 1198..1231; Disordered
Supporting Publications5
| PMID | Title | Related sentences |
|---|---|---|
| 27894104 | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | No related sentences available |
| 33204424 | Proteomic analysis of extracellular vesicles reveals an immunogenic cargo in rheumatoid arthritis synovial fluid. | No related sentences available |
| 38321535 | Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles. | No related sentences available |
| 39505756 | Differential proteomic profiles of exosomes in pediatric and adult adamantinomatous craniopharyngioma cyst fluid. | No related sentences available |
| 40089067 | Metabolic Reprogramming Into a Glycolysis Phenotype Induced by Extracellular Vesicles Derived From Prostate Cancer Cells. | No related sentences available |