Protein detail

CC112

Coiled-coil domain-containing protein 112 (Mutated in bladder cancer protein 1)

Entry name CC112	UniProt ID Q8NEF3	EVMP confidence score 0.38
Supporting publications (n) 2	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Coiled-coil domain-containing protein 112 (Mutated in bladder cancer protein 1)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000164221

Entrez Gene Symbol

CCDC112

Gene Synonym

MGC39633

Gene Description

Coiled-coil domain containing 112

Chromosome

Position

115267190-115296693

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization1

Cell SpecificEsophageal apical cells

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component (2)

Molecular Function

GO:0005515 protein binding

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence10

Ligand-Receptor Signaling (6)

6 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	Yes	No	No
intracellular	intracellular	GO_Intercell	No	No	Yes	No	No
intracellular	intracellular	UniProt_location	No	No	Yes	No	No
intracellular	intracellular	OmniPath	No	No	Yes	No	No
secreted	secreted	HPA_secretome	No	No	Yes	No	No
secreted	secreted	OmniPath	No	No	Yes	No	No

Protein Complex Composition (3)

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database
CCDC112 NOL4 TEX9	O94818 Q8N6V9 Q8NEF3	0:0:0	hu.MAP2
CCDC112 NOL4 NOL4L TEX9	O94818 Q8N6V9 Q8NEF3 Q96MY1	0:0:0:0	hu.MAPhu.MAP2
CCDC112 NOL4L TEX9	Q8N6V9 Q8NEF3 Q96MY1	0:0:0	hu.MAPhu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometryMass spectrometry [LTQ-FT Ultra]R Sequencing	25	40985879 37926756 40831280 36064647 38113368 28680152 37322475 40189497 41068253 33592500 32854315 34473505 32560723 32916986 41307968 36146834 33309826 38607062 32230970 38207106 34576246 37204515 39001700 39207047 38590132

Sequence, Structure & Domains8

Sequences

Length

446

Mass

53,565

Sequence

MEKDKHSHFYNQKSDFRIEHSMLEELENKLIHSRKTERAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLREMMEEIENAINTFKEEQRLIYEELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLPEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQHEKWYQKFLALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDNQKQKEEQRKKQKLAVEAWKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKLLLESYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLELKILDRQAKEDEKSQKQRRLAKLKEKVENNVSRDPSRLYKPTKGWEERTKKIGPTGSGPLLHIPHRAIPTWRQGIQRRV

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8NEF3-1; Sequence=Displayed; Name=2; IsoId=Q8NEF3-2; Sequence=VSP_031624

Alternative Sequence

1; M -> MAALTTVVVAAAATAVAGAVAGAGAATGTGVGATPAPQQSDGCFSTSGGIRPFHLQNWKQKVNQTKKAEFVRTAEKFKNQVINM (in isoform 2)

Domain & Motif Annotations

Compositional Bias

255..268; Basic and acidic residues

Coiled Coil

35..116; 219..400

Region

253..272; Disordered; 390..430; Disordered

Clinical Relevance4

Antibody (2)

HPA045120 HPA050621

Interaction Protein (2)

ENSG00000151575ENSG00000171357

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications2

PMID	Title	Abstract
36741391	Circulating exosomal immuno-oncological checkpoints and cytokines are potential biomarkers to monitor tumor response to anti-PD-1/PD-L1 therapy in non-small cell lung cancer patients.	We have also shown that immuno-oncological proteins isolated from pre-ICIs treated patients were significantly higher in exosomes compared to their soluble-free counterparts (CD152, p=0.0008; CD80, p=0.0182; IDO, p=0.0443; Arginase, p<0.0001; Nectin-2, p<0.0001; NT5E, p<0.0001; Siglec-7, p<0.0001; Siglec-9, p=0.0335; CD28, p=0.0092; GITR, p<0.0001; MICA, p<0.0001).
37547182	Retroviral b-Zip protein (HBZ) contributes to the release of soluble and exosomal immune checkpoint molecules in the context of neuroinflammation.	For the very first time, we demonstrate a unique elevated presence of several stimulatory (CD27, CD28, 4-1BB) and inhibitory (BTLA, CTLA-4, LAG-3, PD-1, PD-L2) ICP receptors in HAM/TSP sera, and in purified exosomes from a HAM/TSP-derived HTLV-1-producing (OSP2) cells.