Protein detail

TRPV3

Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3)

Protein symbol TRPV3	UniProt ID Q8NET8	EVMP score 0.50
Frequency 2	Transmembrane count 6	Protein classification

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3)

Protein Function

Disease related genes
Transporters:Transporter channels and pores
Human disease related genes:Congenital malformations:Congenital malformations of skin
FDA approved drug targets:Small molecule drugs

Transmembrane

431..460; Helical; Name=S1; 480..508; Helical; Name=S2; 520..540; Helical; Name=S3; 546..566; Helical; Name=S4; 570..608; Helical; Name=S5; 650..686; Helical; Name=S6

Transmembrane Count

Ensembl

ENSG00000167723

Entrez Gene Symbol

TRPV3

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue SpecificesophagusCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Lineage SpecificB-cells

Function & Pathway

Protein Function

Disease related genes
Transporters:Transporter channels and pores
Human disease related genes:Congenital malformations:Congenital malformations of skin
FDA approved drug targets:Small molecule drugs

Cellular Component

Molecular Function

Biological Process

KEGG

hsa04750 Inflammatory mediator regulation of TRP channels

Reactome

Mediation Categories

Clinical-translation mediationFusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
TRPV3	MAPK3	P27361	T	264	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper

Ligand-Receptor Signaling

28 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
ion_channel	ion_channel	DGIdb	No	Yes	No	No	No
transient_receptor_potential_cation	ion_channel	HGNC	No	Yes	No	No	No
ion_channel	ion_channel	HGNC	No	Yes	No	No	No
ion_channel	ion_channel	Almen2009	No	Yes	No	No	No

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Regulatory Interaction Network

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
MK03	P27361	TRPV3	Q8NET8	Yes	Yes	No	SIGNORPhosphoSitePhosphoSite_ProtMapperProtMapper	SIGNOR:29084846 PhosphoSite:29084846

Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	TRPV3	Q8NET8	4	PDB	PDB:6mhoPDB:6mhsPDB:6uw4PDB:8gkaPDB:6uw8PDB:8v6kPDB:8gkgPDB:9jefPDB:6mhxPDB:9jegPDB:8v6mPDB:6uw9PDB:9bkuPDB:7xj0PDB:8v6nPDB:8v6lPDB:6ot5PDB:7xj1PDB:9dijPDB:7xj3PDB:9je5PDB:8v6oPDB:6ot2PDB:6mhwPDB:9jdmPDB:6uw6PDB:6mhvPDB:7xj2PDB:9jee
	HIF1AN TRPV3	Q8NET8 Q9NWT6	1:1	PDB	PDB:6h9jPDB:6ha6

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient CentrifugationSize Exclusion ChromatographyMicrofluidics-Based Methods	Mass spectrometry	9	38225453 38556629 40545963 26775013 24505114 33709510 37686366 40091455 31588238

Sequence, Structure & Domains

Sequences

Length

790

Mass

90,636

Sequence

MKAHPKEMVPLMGKRVAAPSGNPAILPEKRPAEITPTKKSAHFFLEIEGFEPNPTVAKTSPPVFSKPMDSNIRQCISGNCDDMDSPQSPQDDVTETPSNPNSPSAQLAKEEQRRKKRRLKKRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNINPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYILSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEMLTLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPREEEAIPHPLALTHKMGWLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFIQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEKCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSKYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSRFRMGELCKVAEDDFRLCLRINEVKWTEWKTHVSFLNEDPGPVRRTDFNKIQDSSRNNSKTTLNAFEEVEEFPETSV

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8NET8-1; Sequence=Displayed; Name=2; Synonyms=A; IsoId=Q8NET8-2; Sequence=VSP_013433; Name=3; Synonyms=B; IsoId=Q8NET8-3; Sequence=VSP_013434, VSP_013435

Alternative Sequence

759; T -> TA (in isoform 2); 760..765; DFNKIQ -> GTVAVR (in isoform 3); 766..790; Missing (in isoform 3)

3D Structural Models

Turn

127..130; 200..202; 236..238; 248..250; 310..312; 393..395; 617..619; 666..668; 748..750

Helix

120..126; 132..148; 154..161; 171..177; 183..196; 218..224; 230..235; 265..271; 275..283; 299..306; 316..328; 332..335; 344..351; 354..361; 371..373; 403..409; 416..419; 423..435; 437..460; 465..468; 483..508; 513..519; 521..542; 547..560; 561..568; 570..585; 587..606; 609..611; 612..614; 625..637; 651..665; 669..685; 688..706; 709..714; 739..747

Beta Strand

72..74; 151..153; 165..167; 210..212; 253..257; 367..369; 375..382; 385..391; 399..401; 412..414; 477..479; 621..624; 646..649; 719..724; 727..737; 787..789

3D Structure

Electron microscopy (29); X-ray crystallography (3)

Domain & Motif Annotations

Compositional Bias

95..105; Polar residues

Repeat

117..148; ANK 1; 170..198; ANK 2; 214..243; ANK 3; 261..291; ANK 4; 298..330; ANK 5; 340..362; ANK 6; 398..420; ANK 7

Region

15..34; Disordered; 52..71; Disordered; 76..112; Disordered

Protein Families

Transient receptor (TC 1.A.4) family
TrpV subfamily
TRPV3 sub-subfamily

Sequence Similarities

Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV3 sub-subfamily.

Clinical Relevance

Related Diseases

Depression Diabetes mellitus Pain

Biomarker

Investigative; Phase 2

Drugs

RACEMENTHOL CHEMBL:CHEMBL120580 GRC-15300