Protein detail
TRPV3
Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3)
Protein symbol TRPV3 | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count 6 | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3)
Protein Function
- Disease related genes
- Transporters:Transporter channels and pores
- Human disease related genes:Congenital malformations:Congenital malformations of skin
- FDA approved drug targets:Small molecule drugs
Transmembrane
431..460; Helical; Name=S1; 480..508; Helical; Name=S2; 520..540; Helical; Name=S3; 546..566; Helical; Name=S4; 570..608; Helical; Name=S5; 650..686; Helical; Name=S6
Transmembrane Count
6
Ensembl
Entrez Gene Symbol
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificesophagusCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Lineage SpecificB-cells
Function & Pathway
Protein Function
- Disease related genes
- Transporters:Transporter channels and pores
- Human disease related genes:Congenital malformations:Congenital malformations of skin
- FDA approved drug targets:Small molecule drugs
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| TRPV3 | MAPK3 | P27361 | T | 264 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper |
Ligand-Receptor Signaling
28 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| peripheral | peripheral | UniProt_topology | No | No | No | No | No |
| peripheral | peripheral | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
| receptor | receptor | CellCellInteractions | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| MK03 | P27361 | TRPV3 | Q8NET8 | Yes | Yes | No | SIGNORPhosphoSitePhosphoSite_ProtMapperProtMapper | SIGNOR:29084846PhosphoSite:29084846 |
Protein Complex Composition
2 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| TRPV3 | Q8NET8 | 4 | PDB | PDB:6mhoPDB:6mhsPDB:6uw4PDB:8gkaPDB:6uw8PDB:8v6kPDB:8gkgPDB:9jefPDB:6mhxPDB:9jegPDB:8v6mPDB:6uw9PDB:9bkuPDB:7xj0PDB:8v6nPDB:8v6lPDB:6ot5PDB:7xj1PDB:9dijPDB:7xj3PDB:9je5PDB:8v6oPDB:6ot2PDB:6mhwPDB:9jdmPDB:6uw6PDB:6mhvPDB:7xj2PDB:9jee | ||
| HIF1ANTRPV3 | Q8NET8Q9NWT6 | 1:1 | PDB | PDB:6h9jPDB:6ha6 |
Isolation & Detection Technology
Sequence, Structure & Domains
Sequences
Length
790
Mass
90,636
Sequence
MKAHPKEMVPLMGKRVAAPSGNPAILPEKRPAEITPTKKSAHFFLEIEGFEPNPTVAKTSPPVFSKPMDSNIRQCISGNCDDMDSPQSPQDDVTETPSNPNSPSAQLAKEEQRRKKRRLKKRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNINPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYILSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEMLTLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPREEEAIPHPLALTHKMGWLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFIQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEKCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSKYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSRFRMGELCKVAEDDFRLCLRINEVKWTEWKTHVSFLNEDPGPVRRTDFNKIQDSSRNNSKTTLNAFEEVEEFPETSV
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8NET8-1; Sequence=Displayed; Name=2; Synonyms=A; IsoId=Q8NET8-2; Sequence=VSP_013433; Name=3; Synonyms=B; IsoId=Q8NET8-3; Sequence=VSP_013434, VSP_013435
Alternative Sequence
759; T -> TA (in isoform 2); 760..765; DFNKIQ -> GTVAVR (in isoform 3); 766..790; Missing (in isoform 3)
3D Structural Models
Turn
127..130; 200..202; 236..238; 248..250; 310..312; 393..395; 617..619; 666..668; 748..750
Helix
120..126; 132..148; 154..161; 171..177; 183..196; 218..224; 230..235; 265..271; 275..283; 299..306; 316..328; 332..335; 344..351; 354..361; 371..373; 403..409; 416..419; 423..435; 437..460; 465..468; 483..508; 513..519; 521..542; 547..560; 561..568; 570..585; 587..606; 609..611; 612..614; 625..637; 651..665; 669..685; 688..706; 709..714; 739..747
Beta Strand
72..74; 151..153; 165..167; 210..212; 253..257; 367..369; 375..382; 385..391; 399..401; 412..414; 477..479; 621..624; 646..649; 719..724; 727..737; 787..789
3D Structure
Electron microscopy (29); X-ray crystallography (3)
Domain & Motif Annotations
Compositional Bias
95..105; Polar residues
Repeat
117..148; ANK 1; 170..198; ANK 2; 214..243; ANK 3; 261..291; ANK 4; 298..330; ANK 5; 340..362; ANK 6; 398..420; ANK 7
Region
15..34; Disordered; 52..71; Disordered; 76..112; Disordered
Protein Families
- Transient receptor (TC 1.A.4) family
- TrpV subfamily
- TRPV3 sub-subfamily
Sequence Similarities
Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV3 sub-subfamily.
Clinical Relevance
Related Diseases
Biomarker
Investigative; Phase 2