Protein detail
ZN397
Zinc finger protein 397 (Zinc finger and SCAN domain-containing protein 15) (Zinc finger protein 47)
Entry name ZN397 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Predicted intracellular proteinsTranscription factors |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Zinc finger protein 397 (Zinc finger and SCAN domain-containing protein 15) (Zinc finger protein 47)
Protein Class (2)
Predicted intracellular proteinsTranscription factors
Protein Function (2)
- Predicted intracellular proteins
- Transcription factors:Zinc-coordinating DNA-binding domains
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
MGC13250ZNF47ZSCAN15
Gene Description
Zinc finger protein 397
Chromosome
18
Position
35241030-35267133
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization4
Tissue SpecificplacentaCell SpecificcDCBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cells
Function & Pathway6
Protein Function (2)
- Predicted intracellular proteins
- Transcription factors:Zinc-coordinating DNA-binding domains
Cellular Component (6)
Molecular Function (6)
- GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
- GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
- GO:0005515 protein binding
- GO:0042803 protein homodimerization activity
- GO:0046872 metal ion binding
- GO:0046982 protein heterodimerization activity
Biological Process (3)
Canonical Pathways (3)
- M5883 Naba secreted factors
- M5885 Naba matrisome associated
- M5889 Naba matrisome
Mediation Categories
Other mediation
Relations & Evidence6
Ligand-Receptor Signaling (4)
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 39535266 |
Sequence, Structure & Domains11
Sequences
Length
534
Mass
61,139
Sequence
MAVESGVISTLIPQDPPEQELILVKVEDNFSWDEKFKQNGSTQSCQELFRQQFRKFCYQETPGPREALSRLQELCYQWLMPELHTKEQILELLVLEQFLSILPEELQIWVQQHNPESGEEAVTLLEDLEREFDDPGQQVPASPQGPAVPWKDLTCLRASQESTDIHLQPLKTQLKSWKPCLSPKSDCENSETATKEGISEEKSQGLPQEPSFRGISEHESNLVWKQGSATGEKLRSPSQGGSFSQVIFTNKSLGKRDLYDEAERCLILTTDSIMCQKVPPEERPYRCDVCGHSFKQHSSLTQHQRIHTGEKPYKCNQCGKAFSLRSYLIIHQRIHSGEKAYECSECGKAFNQSSALIRHRKIHTGEKACKCNECGKAFSQSSYLIIHQRIHTGEKPYECNECGKTFSQSSKLIRHQRIHTGERPYECNECGKAFRQSSELITHQRIHSGEKPYECSECGKAFSLSSNLIRHQRIHSGEEPYQCNECGKTFKRSSALVQHQRIHSGDEAYICNECGKAFRHRSVLMRHQRVHTIK
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=ZNF397-fu; IsoId=Q8NF99-1; Sequence=Displayed; Name=2; IsoId=Q8NF99-2; Sequence=VSP_006924, VSP_006925; Name=3; Synonyms=Truncated, ZNF397-nf; IsoId=Q8NF99-3; Sequence=VSP_042491, VSP_042492
Alternative Sequence
186..207; DCENSETATKEGISEEKSQGLP -> GEEWEIIWKLLTLRPLFLRMQN (in isoform 3); 208..534; Missing (in isoform 3); 216..275; SEHESNLVWKQGSATGEKLRSPSQGGSFSQVIFTNKSLGKRDLYDEAERCLILTTDSIMC -> KLSRPPKASSAIRWECVSPGSFPGDIIAAEATHSTISCFAINTLPATILPSKNVNRKYFS (in isoform 2); 276..534; Missing (in isoform 2)
Domain & Motif Annotations
Compositional Bias
193..203; Basic and acidic residues
Zinc Finger
285..307; C2H2-type 1; 313..335; C2H2-type 2; 341..363; C2H2-type 3; 369..391; C2H2-type 4; 397..419; C2H2-type 5; 425..447; C2H2-type 6; 453..475; C2H2-type 7; 481..503; C2H2-type 8; 509..531; C2H2-type 9
Domain (FT)
50..132; SCAN box
Region
180..217; Disordered
Protein Families
Krueppel C2H2-type zinc-finger protein family
Sequence Similarities
Belongs to the krueppel C2H2-type zinc-finger protein family.
Clinical Relevance4
Antibody
Interaction Protein (2)
ENSG00000083838ENSG00000171222
Interaction Count
2
Interaction Dataset
intact_biogrid
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No abstract available |