Protein detail
NCKX4
Sodium/potassium/calcium exchanger 4 (Na(+)/K(+)/Ca(2+)-exchange protein 4) (Solute carrier family 24 member 4)
Entry name NCKX4 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 10 | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information8
Protein Names
Sodium/potassium/calcium exchanger 4 (Na(+)/K(+)/Ca(2+)-exchange protein 4) (Solute carrier family 24 member 4)
Protein Function (5)
- Predicted intracellular proteins
- Human disease related genes:Digestive system diseases:Mouth and dental diseases
- Potential drug targets
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
Transmembrane
98..118; Helical; 143..163; Helical; 173..193; Helical; 201..221; Helical; 225..245; Helical; 458..478; Helical; 480..500; Helical; 527..547; Helical; 558..578; Helical; 587..607; Helical
Transmembrane Count
10
Ensembl
Entrez Gene Symbol
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization2
Cell SpecificEsophageal apical cellsSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway8
Protein Function (5)
- Predicted intracellular proteins
- Human disease related genes:Digestive system diseases:Mouth and dental diseases
- Potential drug targets
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
Cellular Component (6)
Molecular Function (5)
Biological Process (3)
Reactome (6)
Canonical Pathways (3)
- M5883 Naba secreted factors
- M5885 Naba matrisome associated
- M5889 Naba matrisome
Mediation Categories (4)
Clinical-translation mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence21
Ligand-Receptor Signaling (20)
20 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transporter | transporter | Surfaceome | No | Yes | No | No | No |
| slc24 | transporter | Surfaceome | No | Yes | No | No | No |
| slc | transporter | Surfaceome | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 36982312 |
Sequence, Structure & Domains10
Sequences
Length
622
Mass
69,042
Sequence
MALRGTLRPLKVRRRREMLPQQVGFVCAVLALVCCASGLFGSLGHKTASASKRVLPDTWRNRKLMAPVNGTQTAKNCTDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKMQAFFTVKQKSIANGNPVNSELEAGNDFYDGSYDDPSVPLLGQVKEKPQYGKNPVVMVDEIMSSSPPKFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINSANGVSSKPLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARGDKVKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIMIEFNVFTFVNLPMCREDD
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8NFF2-1; Sequence=Displayed; Name=2; IsoId=Q8NFF2-2; Sequence=VSP_008369; Name=3; IsoId=Q8NFF2-3; Sequence=VSP_008372; Name=4; IsoId=Q8NFF2-4; Sequence=VSP_008370, VSP_008371
Alternative Sequence
1..109; Missing (in isoform 4); 1..64; Missing (in isoform 2); 172..210; Missing (in isoform 4); 275..293; Missing (in isoform 3)
Domain & Motif Annotations
Compositional Bias
380..393; Low complexity; 394..404; Pro residues
Repeat
139..179; Alpha-1; 495..526; Alpha-2
Region
358..410; Disordered
Protein Families (2)
- Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family
- SLC24A subfamily
Sequence Similarities
Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
Clinical Relevance1
Drugs
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 36337342 | Small extracellular vesicles in plasma reveal molecular effects of modified Mediterranean-ketogenic diet in participants with mild cognitive impairment. | L1 cell adhesion molecule, synaptophysin and neural cell adhesion molecule surface markers were used to enrich for neuron-secreted small extracellular vesicles (sEV © The Author(s) 2022. |