Protein detail
FAD1
Bifunctional FAD diphosphatase/FAD synthase [Includes: FAD diphosphatase (EC 3.6.1.18) (EC 3.6.1.22) (FAD pyrophosphatase) (FADPPase) (FADHy) (NADH diphosphatase); FAD synthase (FADSy) (EC 2.7.7.2) (FMN adenylyltransferase) (FMNAT) (Flavin adenine dinucleotide synthase)]
Protein symbol FAD1 | UniProt ID | EVMP score 0.50 |
Frequency 7 | Transmembrane count | Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteins |
Basic Information
Protein Names
Bifunctional FAD diphosphatase/FAD synthase [Includes: FAD diphosphatase (EC 3.6.1.18) (EC 3.6.1.22) (FAD pyrophosphatase) (FADPPase) (FADHy) (NADH diphosphatase); FAD synthase (FADSy) (EC 2.7.7.2) (FMN adenylyltransferase) (FMNAT) (Flavin adenine dinucleotide synthase)]
Protein Class
Disease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteins
Protein Function
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of cofactor/vitamin metabolism
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym
FAD1PP591
Gene Description
Flavin adenine dinucleotide synthetase 1
Chromosome
1
Position
154983338-154993111
Frequency
7
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificbrainCell SpecificBasal prostatic cellsSingle-Nuclei Brain SpecificleukocyteBlood Cell SpecificgdT-cellBlood Lineage SpecificT-cells
Function & Pathway
Protein Function
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of cofactor/vitamin metabolism
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Disease related genes
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Canonical Pathways
- M264 Pid toll endogenous pathway
- M5883 Naba secreted factors
- M5885 Naba matrisome associated
Mediation Categories
Metabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| FLAD1FUOMTAFA3 | A2VDF0Q7Z5A8Q8NFF5 | 0:0:0 | hu.MAP2 | |||
| FLAD1NUDT21RCC1 | O43809P18754Q8NFF5 | 1:1:1 | CompleatCFinder | Compleat:HC4937 | ||
| CSNK2BCYP3A4FLAD1FTH1HMGCS1JMJD6NDUFS1 | P02794P08684P28331P67870Q01581Q6NYC1Q8NFF5 | 1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC4383 | ||
| FLAD1 | Q8NFF5 | 4 | PDB | PDB:8ron |
Sequence, Structure & Domains
Sequences
Length
587
Mass
65,266
Sequence
MGWDLGTRLFQRQEQRSRLSRIWLEKTRVFLEGSTRTPALPHCLFWLLQVPSTQDPLFPGYGPQCPVDLAGPPCLRPLFGGLGGYWRALQRGREGRTMTSRASELSPGRSVTAGIIIVGDEILKGHTQDTNTFFLCRTLRSLGVQVCRVSVVPDEVATIAAEVTSFSNRFTHVLTAGGIGPTHDDVTFEAVAQAFGDELKPHPKLEAATKALGGEGWEKLSLVPSSARLHYGTDPCTGQPFRFPLVSVRNVYLFPGIPELLRRVLEGMKGLFQNPAVQFHSKELYVAADEASIAPILAEAQAHFGRRLGLGSYPDWGSNYYQVKLTLDSEEEGPLEECLAYLTARLPQGSLVPYMPNAVEQASEAVYKLAESGSSLGKKVAGALQTIETSLAQYSLTQLCVGFNGGKDCTALLHLFHAAVQRKLPDVPNPLQILYIRSISPFPELEQFLQDTIKRYNLQMLEAEGSMKQALGELQARHPQLEAVLMGTRRTDPYSCSLCPFSPTDPGWPAFMRINPLLDWTYRDIWDFLRQLFVPYCILYDRGYTSLGSRENTVRNPALKCLSPGGHPTYRPAYLLENEEEERNSRT
Alternative Products
Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=FADS1; IsoId=Q8NFF5-1; Sequence=Displayed; Name=2; Synonyms=FADS2; IsoId=Q8NFF5-2; Sequence=VSP_027947; Name=3; IsoId=Q8NFF5-3; Sequence=VSP_027947, VSP_027954; Name=4; IsoId=Q8NFF5-4; Sequence=VSP_027948, VSP_027949, VSP_027951, VSP_027952; Name=5; IsoId=Q8NFF5-5; Sequence=VSP_027948, VSP_027949, VSP_027950, VSP_027953
Alternative Sequence
1..97; Missing (in isoform 2 and isoform 3); 1..30; Missing (in isoform 4 and isoform 5); 31..124; LEGSTRTPALPHCLFWLLQVPSTQDPLFPGYGPQCPVDLAGPPCLRPLFGGLGGYWRALQRGREGRTMTSRASELSPGRSVTAGIIIVGDEILK -> MQPSSSTPPLHPYSTDGLIFPFNPQ (in isoform 4 and isoform 5); 374..437; SSLGKKVAGALQTIETSLAQYSLTQLCVGFNGGKDCTALLHLFHAAVQRKLPDVPNPLQILYIR -> NYLMFQTPSRSCISAASPLSLSWNSFYRTLSREQAIPENQIASPPSEAKGAEEPWMGPFPGQQG (in isoform 5); 374..393; SSLGKKVAGALQTIETSLAQ -> RDLMEEGHYAQSHWWHPRSQ (in isoform 4); 394..587; Missing (in isoform 4); 438..587; Missing (in isoform 5); 544..587; Missing (in isoform 3)
3D Structural Models
Turn
235..237; 358..361; 396..398; 516..519; 550..552
Helix
120..124; 131..141; 156..169; 187..194; 203..211; 218..221; 258..268; 269..272; 290..304; 333..345; 362..370; 375..393; 407..423; 443..456; 467..477; 493..496; 522..531; 538..541; 579..584
Beta Strand
112..118; 145..152; 171..177; 180..182; 199..201; 222..224; 228..230; 238..240; 245..248; 251..254; 280..288; 309..314; 322..332; 372..374; 399..402; 425..427; 432..437; 459..466; 483..485; 500..503; 506..508; 512..514
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Region
110..354; FAD diphosphatase; 355..587; FAD synthase
Protein Families
- MoaB/Mog family
- PAPS reductase family, FAD1 subfamily
Sequence Similarities
In the N-terminal section; belongs to the MoaB/Mog family.; SIMILARITY: In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.