Protein detail

RAI3

Retinoic acid-induced protein 3 (G-protein coupled receptor family C group 5 member A) (Phorbol ester induced gene 1) (PEIG-1) (Retinoic acid-induced gene 1 protein) (RAIG-1)

Entry name RAI3	UniProt ID Q8NFJ5	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count 7	Protein classification G-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Retinoic acid-induced protein 3 (G-protein coupled receptor family C group 5 member A) (Phorbol ester induced gene 1) (PEIG-1) (Retinoic acid-induced gene 1 protein) (RAIG-1)

Protein Class (3)

G-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteins

Protein Function (3)

G-protein coupled receptors:Family 3 (C) receptors
Predicted intracellular proteins
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

34..54; Helical; Name=1; 69..89; Helical; Name=2; 98..118; Helical; Name=3; 130..150; Helical; Name=4; 177..197; Helical; Name=5; 213..233; Helical; Name=6; 248..268; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000013588

Entrez Gene Symbol

GPRC5A

Gene Synonym (4)

PEIG-1RAI3RAIG1TIG1

Gene Description

G protein-coupled receptor class C group 5 member A

Chromosome

Position

12891559-12917937

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization5

Tissue SpecificlungCell SpecificcDCSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificclassical monocyteBlood Lineage SpecificB-cells

Function & Pathway5

Protein Function (3)

G-protein coupled receptors:Family 3 (C) receptors
Predicted intracellular proteins
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component (7)

Molecular Function (4)

Biological Process (3)

Mediation Categories

Receptor-signaling mediation

Relations & Evidence51

Enzyme-Mediated Modification (4)

4 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
GPRC5A	EGFR	P00533	Y	350	phosphorylation	REACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper	ProtMapper:25311788
GPRC5A	EGFR	P00533	Y	320	phosphorylation	REACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper	ProtMapper:25311788
GPRC5A	EGFR	P00533	Y	317	phosphorylation	REACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper	ProtMapper:25311788
GPRC5A	EGFR	P00533	Y	347	phosphorylation	REACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper	ProtMapper:25311788

Ligand-Receptor Signaling (43)

43 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	HPMR	No	Yes	No	Yes	No
receptor	receptor	Surfaceome	No	Yes	No	Yes	No
gpcr	receptor	DGIdb	No	Yes	No	Yes	No
gpcr	receptor	Almen2009	No	Yes	No	Yes	No
glutamate	receptor	Almen2009	No	Yes	No	Yes	No
gpcr	receptor	UniProt_keyword	No	Yes	No	Yes	No
seven_transmembrane_7tm	receptor	HPMR	No	Yes	No	Yes	No
7tm_c	receptor	HPMR	No	Yes	No	Yes	No
metabotropic_glutamate_receptor_7tm_c	receptor	HPMR	No	Yes	No	Yes	No
glutamate	receptor	Surfaceome	No	Yes	No	Yes	No

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
EGFR	P00533	RAI3	Q8NFJ5	Yes	No	Yes	PhosphoSite_norefSIGNORiPTMnetProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:25311788 PhosphoSite:25311788 SIGNOR:25311788

Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	GPRC5A GTF2F2 HSP90AA2P HSPA9	P13984 P38646 Q14568 Q8NFJ5	0:0:0:0	Havugimana2012	Havugimana2012:C_305
	CHMP2B GOLT1B GPRC5A KIDINS220 RABAC1 TMUB1 XPR1	Q8NFJ5 Q9BVT8 Q9UBH6 Q9UI14 Q9ULH0 Q9UQN3 Q9Y3E0	0:0:0:0:0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	27605433

Sequence, Structure & Domains5

Sequences

Length

357

Mass

40,251

Sequence

MATTVPDGCRNGLKSKYYRLCDKAEAWGIVLETVATAGVVTSVAFMLTLPILVCKVQDSNRRKMLPTQFLFLLGVLGIFGLTFAFIIGLDGSTGPTRFFLFGILFSICFSCLLAHAVSLTKLVRGRKPLSLLVILGLAVGFSLVQDVIAIEYIVLTMNRTNVNVFSELSAPRRNEDFVLLLTYVLFLMALTFLMSSFTFCGSFTGWKRHGAHIYLTMLLSIAIWVAWITLLMLPDFDRRWDDTILSSALAANGWVFLLAYVSPEFWLLTKQRNPMDYPVEDAFCKPQLVKKSYGVENRAYSQEEITQGFEETGDTLYAPYSTHFQLQNQPPQKEFSIPRAHAWPSPYKDYEVKKEGS

Domain & Motif Annotations

Protein Families

G-protein coupled receptor 3 family

Sequence Similarities

Belongs to the G-protein coupled receptor 3 family.

Clinical Relevance2

Disease Involvement

Tumor suppressor

Antibody (2)

HPA007928 HPA046526

Supporting Publications1

PMID	Title	Abstract
39025337	Shotgun proteomics of thyroid carcinoma exosomes - Insight into the role of exosomal proteins in carcinogenesis and thyroid homeostasis.	No abstract available