Protein detail

GP156

Probable G-protein coupled receptor 156 (G-protein coupled receptor PGR28) (GABAB-related G-protein coupled receptor)

Entry name GP156	UniProt ID Q8NFN8	EVMP confidence score 0.50
Supporting publications (n) 4	Transmembrane count 7	Protein classification G-protein coupled receptorsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Probable G-protein coupled receptor 156 (G-protein coupled receptor PGR28) (GABAB-related G-protein coupled receptor)

Protein Class (3)

G-protein coupled receptorsPredicted membrane proteinsTransporters

Protein Function (3)

G-protein coupled receptors:Family 3 (C) receptors
Transporters
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

48..68; Helical; 87..107; Helical; 119..139; Helical; 165..185; Helical; 223..243; Helical; 258..278; Helical; 289..309; Helical

Transmembrane Count

Ensembl

ENSG00000175697

Entrez Gene Symbol

GPR156

Gene Synonym (2)

GABABLPGR28

Gene Description

G protein-coupled receptor 156

Chromosome

Position

120164645-120285222

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization6

Cell SpecificLate spermatidsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificclassical monocyteBlood Lineage Specificdendritic cellsSecretome LocationSecreted to bloodSecretome FunctionChemokine

Function & Pathway7

Protein Function (3)

G-protein coupled receptors:Family 3 (C) receptors
Transporters
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component (2)

Molecular Function

GO:0004965 G protein-coupled GABA receptor activity

Biological Process (3)

KEGG

hsa04080 Neuroactive ligand-receptor interaction

Canonical Pathways (3)

M155 Pid s1p meta pathway
M268 Pid s1p s1p2 pathway
M55 Pid s1p s1p3 pathway

Mediation Categories

Receptor-signaling mediation

Relations & Evidence39

Ligand-Receptor Signaling (37)

37 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
gpcr	receptor	Surfaceome	No	Yes	No	Yes	No
class_c_glutamate	receptor	GPCRdb	No	Yes	No	Yes	No
class_c_glutamate_orphan	receptor	GPCRdb	No	Yes	No	Yes	No
class_c_glutamate_orphan_class_c_orphans	receptor	GPCRdb	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	HPMR	No	No	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	GPR156	Q8NFN8	2	PDB	PDB:8yjpPDB:8ieqPDB:8ieiPDB:8iepPDB:8ieb

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometryR Sequencing	6	38113368 37322475 40189497 32854315 41307968 38207106

Sequence, Structure & Domains14

Sequences

Length

814

Mass

89,097

Sequence

MEPEINCSELCDSFPGQELDRRPLHDLCKTTITSSHHSSKTISSLSPVLLGIVWTFLSCGLLLILFFLAFTIHCRKNRIVKMSSPNLNIVTLLGSCLTYSSAYLFGIQDVLVGSSMETLIQTRLSMLCIGTSLVFGPILGKSWRLYKVFTQRVPDKRVIIKDLQLLGLVAALLMADVILLMTWVLTDPIQCLQILSVSMTVTGKDVSCTSTSTHFCASRYSDVWIALIWGCKGLLLLYGAYLAGLTGHVSSPPVNQSLTIMVGVNLLVLAAGLLFVVTRYLHSWPNLVFGLTSGGIFVCTTTINCFIFIPQLKQWKAFEEENQTIRRMAKYFSTPNKSFHTQYGEEENCHPRGEKSSMERLLTEKNAVIESLQEQVNNAKEKIVRLMSAECTYDLPEGAAPPASSPNKDVQAVASVHTLAAAQGPSGHLSDFQNDPGMAARDSQCTSGPSSYAQSLEGPGKDSSFSPGKEEKISDSKDFSDHLDSGCSQKPWTEQSLGPERGDQVPMNPSQSLLPERGGSDPQRQRHLENSEEPPERRSRVSSVIREKLQEVLQDLGLGPEASLSTAPSCHQQTWKNSAAFSPQKMPLSKELGFSPYMVRRRRAAQRARSHFPGSAPSSVGHRANRTVPGAHSRLHVQNGDSPSLAPQTTDSRVRRPSSRKPSLPSDPQDRPGTLEGSKQSQTEPEGARGSKAAFLRQPSGSGRAPSPAAPCLSKASPDLPEQWQLWPPVPSGCASLSSQHSYFDTESSSSDEFFCRCHRPYCEICFQSSSDSSDSGTSDTDPEPTGGLASWEKLWARSKPIVNFKDDLKPTLV

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8NFN8-1; Sequence=Displayed; Name=2; IsoId=Q8NFN8-2; Sequence=VSP_044603

Alternative Sequence

197..200; Missing (in isoform 2)

3D Structural Models

Turn

34..37; 74..76; 246..248; 281..283

Helix

23..33; 47..73; 78..82; 85..104; 115..148; 162..186; 221..245; 252..255; 257..280; 285..318; 325..327; 328..331

Beta Strand

111..113; 154..156; 190..201; 206..217

3D Structure

Electron microscopy (7)

Domain & Motif Annotations

Compositional Bias

443..454; Polar residues; 468..484; Basic and acidic residues; 486..496; Polar residues; 523..545; Basic and acidic residues; 563..581; Polar residues; 599..610; Basic residues; 639..651; Polar residues; 769..780; Low complexity

Coiled Coil

354..390

Region

422..545; Disordered; 557..724; Disordered; 769..792; Disordered

Protein Families (2)

G-protein coupled receptor 3 family
GABA-B receptor subfamily

Sequence Similarities

Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.

Clinical Relevance2

Disease Involvement (2)

DeafnessNon-syndromic deafness

Antibody (2)

HPA028642 HPA028644

Supporting Publications4

PMID	Title	Abstract
28240915	Quantitative Proteomic Analysis of Serum Exosomes from Patients with Locally Advanced Pancreatic Cancer Undergoing Chemoradiotherapy.	No abstract available
31414377	Global extracellular vesicle proteomic signature defines U87-MG glioma cell hypoxic status with potential implications for non-invasive diagnostics.	No abstract available
32331267	Mass Spectrometry-Based Proteomic Characterization of Cutaneous Melanoma Ectosomes Reveals the Presence of Cancer-Related Molecules.	No abstract available
33169421	A novel method of high-purity extracellular vesicle enrichment from microliter-scale human serum for proteomic analysis.	No abstract available