Protein detail
MDGA1
MAM domain-containing glycosylphosphatidylinositol anchor protein 1 (GPI and MAM protein) (GPIM) (Glycosylphosphatidylinositol-MAM) (MAM domain-containing protein 3)
Entry name MDGA1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
MAM domain-containing glycosylphosphatidylinositol anchor protein 1 (GPI and MAM protein) (GPIM) (Glycosylphosphatidylinositol-MAM) (MAM domain-containing protein 3)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
GPIMMAMDC3
Gene Description
MAM domain containing glycosylphosphatidylinositol anchor 1
Chromosome
6
Position
37630679-37699306
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificbrainCell SpecificAdrenal medulla cellsSingle-Nuclei Brain Specificupper rhombic lip
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Canonical Pathways
- M155 Pid s1p meta pathway
- M55 Pid s1p s1p3 pathway
Mediation Categories
Adhesion and uptake mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
15 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | Yes |
| intracellular | intracellular | GO_Intercell | No | No | No | No | Yes |
| intracellular | intracellular | OmniPath | No | No | No | No | Yes |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | No | Yes |
| adhesion | adhesion | OmniPath | Yes | Yes | No | No | Yes |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | No | Yes |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | Yes |
| transmembrane | transmembrane | OmniPath | No | No | No | No | Yes |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | Yes |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | No | Yes |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass SpectrometryElisa | 1 | 36982312 |
Sequence, Structure & Domains
Sequences
Length
955
Mass
105,790
Sequence
MEVTCLLLLALIPFHCRGQGVYAPAQAQIVHAGQACVVKEDNISERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDTPNPTRSHKLSKNYSYVLQWTQREPDAVDPVLNYRLSIRQLNQHNAVVKAIPVRRVEKGQLLEYILTDLRVPHSYEVRLTPYTTFGAGDMASRIIHYTEPINSPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDISGTPEGYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNLLVRSRNKGALDTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDVTLKKGECPRKQTDPNKVVVMPGSGAPCQSSPQLWGPMAIFLLALQR
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8NFP4-1; Sequence=Displayed; Name=2; IsoId=Q8NFP4-2; Sequence=VSP_009835
Alternative Sequence
926..955; VVVMPGSGAPCQSSPQLWGPMAIFLLALQR -> GARREGGGGAESGGSCAWRGFLSVEGGCLGLNRGSECLSDGNHVALTV (in isoform 2)
3D Structural Models
Turn
178..180
Helix
81..83; 100..102; 221..223; 300..302
Beta Strand
23..33; 36..40; 45..51; 56..66; 69..74; 77..79; 93..95; 104..111; 113..116; 118..129; 133..139; 152..158; 161..163; 166..174; 184..187; 193..201; 206..208; 210..217; 227..232; 241..246; 248..252; 258..266; 272..274; 292..297; 304..311; 318..326
3D Structure
X-ray crystallography (3)
Domain & Motif Annotations
Compositional Bias
779..788; Polar residues
Domain (FT)
24..123; Ig-like 1; 132..230; Ig-like 2; 240..323; Ig-like 3; 338..432; Ig-like 4; 440..532; Ig-like 5; 539..631; Ig-like 6; 643..743; Fibronectin type-III; 751..918; MAM
Region
779..798; Disordered