Protein detail
DNER
Delta and Notch-like epidermal growth factor-related receptor
Entry name DNER | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification Cancer-related genesPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Delta and Notch-like epidermal growth factor-related receptor
Protein Class (2)
Cancer-related genesPredicted membrane proteins
Protein Function
Cancer-related genes:Mutated cancer genes
Transmembrane
641..661; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
betUNQ26
Gene Description
Delta/notch like EGF repeat containing
Chromosome
2
Position
229357629-229714555
Supporting publications (n)
1
EVMP confidence score
0.25
Fluorescence & Localization3
Cell SpecificAstrocytesSingle-Nuclei Brain Specificcommitted oligodendrocyte precursorBlood Lineage SpecificNK-cells
Function & Pathway7
Protein Function
Cancer-related genes:Mutated cancer genes
Cellular Component (4)
Molecular Function (5)
Biological Process (3)
Reactome (3)
Canonical Pathways (2)
- M64 Pid s1p s1p4 pathway
- M155 Pid s1p meta pathway
Mediation Categories (2)
Fusion and delivery mediationReceptor-signaling mediation
Relations & Evidence26
Ligand-Receptor Signaling (24)
24 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
| transmembrane_phobius | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
| transmembrane_sosui | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
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Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| DNER | Q8NFT8 | NOTC1 | P46531 | Yes | Yes | No | SIGNOR | SIGNOR:15965470 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass SpectrometryElisa | 1 | 36982312 |
Sequence, Structure & Domains5
Sequences
Length
737
Mass
78,475
Sequence
MQPRRAQAPGAQLLPALALLLLLLGAGPRGSSLANPVPAAPLSAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQALPSLPATGWTESMAPRQLQPVPATQEPDKILPRSQATVTLPTWQPKTGQKVVEMKWDQVEVIPDIACGNASSNSSAGGRLVSFEVPQNTSVKIRQDATASLILLWKVTATGFQQCSLIDGRSVTPLQASGGLVLLEEMLALGNNHFIGFVNDSVTKSIVALRLTLVVKVSTCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHLQWKSGHMAESLTNMPRHSLYIIIGALCVAFILMLIILIVGICRISRIEYQGSSRPAYEEFYNCRSIDSEFSNAIASIRHARFGKKSRPAMYDVSPIAYEDYSPDDKPLVTLIKTKDL
Domain & Motif Annotations
Domain (FT)
44..92; EGF-like 1; 94..133; EGF-like 2; 309..348; EGF-like 3; 349..390; EGF-like 4; 392..428; EGF-like 5; 430..466; EGF-like 6; 468..503; EGF-like 7; 505..541; EGF-like 8; calcium-binding; 543..579; EGF-like 9; 546..568; Follistatin-like; 581..617; EGF-like 10; calcium-binding
Region
44..133; Interaction with NOTCH1; 677..680; Interaction with AP1G1 and somatodendritic targeting
Clinical Relevance3
Disease Involvement
Cancer-related genes
Drugs (14)
Antibody
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 27894104 | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | No abstract available |