Protein detail
SEM6D
Semaphorin-6D
Entry name SEM6D | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Semaphorin-6D
Protein Function
Predicted intracellular proteins
Transmembrane
663..683; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Supporting publications (n)
1
EVMP confidence score
0.40
Fluorescence & Localization
Cell SpecificBergmann gliaSingle-Nuclei Brain SpecificBergmann glia
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (4)
Molecular Function (4)
Biological Process (3)
Reactome (3)
Canonical Pathways (2)
- M64 Pid s1p s1p4 pathway
- M155 Pid s1p meta pathway
Mediation Categories (2)
Immune mediationReceptor-signaling mediation
Relations & Evidence50
Ligand-Receptor Signaling (49)
49 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | LOCATE | Yes | ||||
| extracellular | extracellular | OmniPath | Yes | ||||
| intracellular | intracellular | LOCATE | Yes | ||||
| intracellular | intracellular | GO_Intercell | Yes | ||||
| intracellular | intracellular | UniProt_location | Yes | ||||
| intracellular | intracellular | OmniPath | Yes | ||||
| cell_surface_ligand | cell_surface_ligand | connectomeDB2020 | Yes | Yes | |||
| cell_surface_ligand | cell_surface_ligand | CellChatDB | Yes | Yes | |||
| cell_surface_ligand | cell_surface_ligand | Baccin2019 | Yes | Yes | |||
| cell_surface_ligand | cell_surface_ligand | CellPhoneDB | Yes | Yes |
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Sequence, Structure & Domains
Sequences
Length
1,073
Mass
119,872
Sequence
MRVFLLCAYILLLMVSQLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQLMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGSCGRVTPGMLAEGYEQDTEFGNTAHLGDCHEILPTSTTPDYKIFGGPTSDMEVSSSSVTTMASIPEITPKVIDTWRPKLTSSRKFVVQDDPNTSDFTDPLSGIPKGVRWEVQSGESNQMVHMNVLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFAKLNGLFDSPVKEYQQNIDSPKLYSNLLTSRKELPPNGDTKSMVMDHRGQPPELAALPTPESTPVLHQKTLQAMKSHSEKAHGHGASRKETPQFFPSSPPPHSPLSHGHIPSAIVLPNATHDYNTSFSNSNAHKAEKKLQNIDHPLTKSSSKRDHRRSVDSRNTLNDLLKHLNDPNSNPKAIMGDIQMAHQNLMLDPMGSMSEVPPKVPNREASLYSPPSTLPRNSPTKRVDVPTTPGVPMTSLERQRGYHKNSSQRHSISAMPKNLNSPNGVLLSRQPSMNRGGYMPTPTGAKVDYIQGTPVSVHLQPSLSRQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTPSVRPLNKYTY
Alternative Products
Event=Alternative splicing; Named isoforms=8; Name=4; Synonyms=SEMA6D.4; IsoId=Q8NFY4-1; Sequence=Displayed; Name=1; Synonyms=SEMA6D.1; IsoId=Q8NFY4-2; Sequence=VSP_016565, VSP_016566; Name=2; Synonyms=SEMA6D.2; IsoId=Q8NFY4-3; Sequence=VSP_016566; Name=3; Synonyms=SEMA6D.3; IsoId=Q8NFY4-4; Sequence=VSP_016567; Name=5; IsoId=Q8NFY4-5; Sequence=VSP_016565, VSP_016567; Name=6; IsoId=Q8NFY4-6; Sequence=VSP_016572; Name=7; Synonyms=SEMA6Ds, Short; IsoId=Q8NFY4-7; Sequence=VSP_016564; Name=8; IsoId=Q8NFY4-8; Sequence=VSP_016572, VSP_054084
Alternative Sequence
477..1073; Missing (in isoform 7); 549; L -> LLLTEDFFAFHNHS (in isoform 1 and isoform 5); 570..644; Missing (in isoform 1 and isoform 2); 570..588; Missing (in isoform 6 and isoform 8); 589..644; Missing (in isoform 3 and isoform 5); 601..1073; ASIPEITPKVIDTWRPKLTSSRKFVVQDDPNTSDFTDPLSGIPKGVRWEVQSGESNQMVHMNVLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFAKLNGLFDSPVKEYQQNIDSPKLYSNLLTSRKELPPNGDTKSMVMDHRGQPPELAALPTPESTPVLHQKTLQAMKSHSEKAHGHGASRKETPQFFPSSPPPHSPLSHGHIPSAIVLPNATHDYNTSFSNSNAHKAEKKLQNIDHPLTKSSSKRDHRRSVDSRNTLNDLLKHLNDPNSNPKAIMGDIQMAHQNLMLDPMGSMSEVPPKVPNREASLYSPPSTLPRNSPTKRVDVPTTPGVPMTSLERQRGYHKNSSQRHSISAMPKNLNSPNGVLLSRQPSMNRGGYMPTPTGAKVDYIQGTPVSVHLQPSLSRQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTPSVRPLNKYTY -> VYDGKSSLESPTRWST (in isoform 8)
Domain & Motif Annotations
Compositional Bias
790..805; Basic and acidic residues; 931..942; Polar residues; 980..995; Polar residues; 1021..1037; Polar residues
Domain (FT)
27..512; Sema; 514..569; PSI
Region
744..775; Disordered; 787..825; Disordered; 839..874; Disordered; 914..1005; Disordered; 1021..1073; Disordered
Protein Families
Semaphorin family
Sequence Similarities
Belongs to the semaphorin family.
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 39535266 | Divergent Proteomic Profiles and Uptake Mechanisms of Exosomes Derived from Human Dental Pulp Stem Cells, Endothelial Cells, and Fibroblasts. | No related sentences available |