Protein detail

SEM6D

Semaphorin-6D

Entry name SEM6D	UniProt ID Q8NFY4	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count 1	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Semaphorin-6D

Protein Function

Predicted intracellular proteins

Transmembrane

663..683; Helical

Transmembrane Count

Ensembl

ENSG00000137872

Entrez Gene Symbol

SEMA6D

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization2

Cell SpecificBergmann gliaSingle-Nuclei Brain SpecificBergmann glia

Function & Pathway8

Protein Function

Predicted intracellular proteins

Cellular Component (4)

Molecular Function (4)

Biological Process (3)

KEGG

hsa04360 Axon guidance

Reactome (3)

Canonical Pathways (2)

M64 Pid s1p s1p4 pathway
M155 Pid s1p meta pathway

Mediation Categories (2)

Immune mediationReceptor-signaling mediation

Relations & Evidence50

Ligand-Receptor Signaling (49)

49 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
extracellular	extracellular	LOCATE	No	No	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	LOCATE	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	UniProt_location	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	connectomeDB2020	Yes	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	CellChatDB	Yes	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	Baccin2019	Yes	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	CellPhoneDB	Yes	No	No	Yes	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	2	39535266 38576002

Sequence, Structure & Domains10

Sequences

Length

1,073

Mass

119,872

Sequence

MRVFLLCAYILLLMVSQLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQLMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGSCGRVTPGMLAEGYEQDTEFGNTAHLGDCHEILPTSTTPDYKIFGGPTSDMEVSSSSVTTMASIPEITPKVIDTWRPKLTSSRKFVVQDDPNTSDFTDPLSGIPKGVRWEVQSGESNQMVHMNVLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFAKLNGLFDSPVKEYQQNIDSPKLYSNLLTSRKELPPNGDTKSMVMDHRGQPPELAALPTPESTPVLHQKTLQAMKSHSEKAHGHGASRKETPQFFPSSPPPHSPLSHGHIPSAIVLPNATHDYNTSFSNSNAHKAEKKLQNIDHPLTKSSSKRDHRRSVDSRNTLNDLLKHLNDPNSNPKAIMGDIQMAHQNLMLDPMGSMSEVPPKVPNREASLYSPPSTLPRNSPTKRVDVPTTPGVPMTSLERQRGYHKNSSQRHSISAMPKNLNSPNGVLLSRQPSMNRGGYMPTPTGAKVDYIQGTPVSVHLQPSLSRQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTPSVRPLNKYTY

Alternative Products

Event=Alternative splicing; Named isoforms=8; Name=4; Synonyms=SEMA6D.4; IsoId=Q8NFY4-1; Sequence=Displayed; Name=1; Synonyms=SEMA6D.1; IsoId=Q8NFY4-2; Sequence=VSP_016565, VSP_016566; Name=2; Synonyms=SEMA6D.2; IsoId=Q8NFY4-3; Sequence=VSP_016566; Name=3; Synonyms=SEMA6D.3; IsoId=Q8NFY4-4; Sequence=VSP_016567; Name=5; IsoId=Q8NFY4-5; Sequence=VSP_016565, VSP_016567; Name=6; IsoId=Q8NFY4-6; Sequence=VSP_016572; Name=7; Synonyms=SEMA6Ds, Short; IsoId=Q8NFY4-7; Sequence=VSP_016564; Name=8; IsoId=Q8NFY4-8; Sequence=VSP_016572, VSP_054084

Alternative Sequence

477..1073; Missing (in isoform 7); 549; L -> LLLTEDFFAFHNHS (in isoform 1 and isoform 5); 570..644; Missing (in isoform 1 and isoform 2); 570..588; Missing (in isoform 6 and isoform 8); 589..644; Missing (in isoform 3 and isoform 5); 601..1073; ASIPEITPKVIDTWRPKLTSSRKFVVQDDPNTSDFTDPLSGIPKGVRWEVQSGESNQMVHMNVLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFAKLNGLFDSPVKEYQQNIDSPKLYSNLLTSRKELPPNGDTKSMVMDHRGQPPELAALPTPESTPVLHQKTLQAMKSHSEKAHGHGASRKETPQFFPSSPPPHSPLSHGHIPSAIVLPNATHDYNTSFSNSNAHKAEKKLQNIDHPLTKSSSKRDHRRSVDSRNTLNDLLKHLNDPNSNPKAIMGDIQMAHQNLMLDPMGSMSEVPPKVPNREASLYSPPSTLPRNSPTKRVDVPTTPGVPMTSLERQRGYHKNSSQRHSISAMPKNLNSPNGVLLSRQPSMNRGGYMPTPTGAKVDYIQGTPVSVHLQPSLSRQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTPSVRPLNKYTY -> VYDGKSSLESPTRWST (in isoform 8)

Domain & Motif Annotations

Compositional Bias

790..805; Basic and acidic residues; 931..942; Polar residues; 980..995; Polar residues; 1021..1037; Polar residues

Domain (FT)

27..512; Sema; 514..569; PSI

Region

744..775; Disordered; 787..825; Disordered; 839..874; Disordered; 914..1005; Disordered; 1021..1073; Disordered

Protein Families

Semaphorin family

Sequence Similarities

Belongs to the semaphorin family.

Supporting Publications1

PMID	Title	Abstract
39535266	Divergent Proteomic Profiles and Uptake Mechanisms of Exosomes Derived from Human Dental Pulp Stem Cells, Endothelial Cells, and Fibroblasts.	No abstract available