Protein detail
NLGN2
Neuroligin-2
Entry name NLGN2 | UniProt ID | EVMP confidence score 0.47 |
Supporting publications (n) 12 | Transmembrane count 1 | Protein classification Predicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Neuroligin-2
Protein Class (3)
Predicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function (2)
- Predicted intracellular proteins
- Transporters:Accessory Factors Involved in Transport
Transmembrane
678..698; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
KIAA1366
Gene Description
Neuroligin 2
Chromosome
17
Position
7404874-7419860
Supporting publications (n)
12
EVMP confidence score
0.47
Fluorescence & Localization4
Tissue Specificadrenal glandCell SpecificAdrenal cortex cellsSingle-Nuclei Brain Specifichippocampal CA1-3
Function & Pathway7
Protein Function (2)
- Predicted intracellular proteins
- Transporters:Accessory Factors Involved in Transport
Cellular Component (15)
- GO:0005886 plasma membrane
- GO:0009986 cell surface
- GO:0016020 membrane
- GO:0030424 axon
- GO:0042734 presynaptic membrane
- GO:0043198 dendritic shaft
- GO:0045202 synapse
- GO:0045211 postsynaptic membrane
- GO:0060076 excitatory synapse
- GO:0060077 inhibitory synapse
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Molecular Function (4)
Biological Process (3)
Reactome (3)
Mediation Categories (2)
Adhesion and uptake mediationFusion and delivery mediation
Relations & Evidence73
Ligand-Receptor Signaling (54)
54 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_surface_ligand | cell_surface_ligand | OmniPath | Yes | No | No | Yes | No |
| neuroligin | cell_adhesion | HGNC | Yes | Yes | No | Yes | No |
| adhesion | adhesion | HGNC | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | Zhong2015 | Yes | Yes | No | Yes | No |
| icam | cell_adhesion | Zhong2015 | Yes | Yes | No | Yes | No |
| neuroligin | cell_adhesion | Almen2009 | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | Almen2009 | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | HGNC | Yes | Yes | No | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
Regulatory Interaction Network (15)
15 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| NLGN2 | Q8NFZ4 | NRX3B | Q9HDB5 | Yes | Yes | No | CellTalkDBFantom5_LRdbHPMR_LRdbiTALKCellPhoneDBHPMR_CellinkertalklrRamilowski2015SIGNORconnectomeDB2020CellinkerWangLRdbHPMR_talklr | LRdb:8576240connectomeDB2020:8576240SIGNOR:18923512Cellinker:8576240CellTalkDB:8576240 |
| NRX3B | Q9HDB5 | NLGN2 | Q8NFZ4 | Yes | Yes | No | CellPhoneDBCellChatDBWangSIGNOR | SIGNOR:22626546SIGNOR:22626547 |
| NLGN2 | Q8NFZ4 | NRX3A | Q9Y4C0 | Yes | Yes | No | CellTalkDBFantom5_LRdbHPMR_LRdbiTALKCellPhoneDBHPMR_CellinkertalklrRamilowski2015SIGNORconnectomeDB2020CellinkerWangLRdbHPMR_talklr | LRdb:8576240connectomeDB2020:8576240SIGNOR:18923512Cellinker:8576240CellTalkDB:8576240 |
| NRX3A | Q9Y4C0 | NLGN2 | Q8NFZ4 | Yes | Yes | No | CellPhoneDBCellChatDBWangSIGNOR | SIGNOR:22626546SIGNOR:22626547 |
| NLGN2 | Q8NFZ4 | NRX1A | Q9ULB1 | Yes | Yes | No | iTALKSIGNORHPMR_talklrHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019CellinkerEMBRACECellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb | LRdb:8576240connectomeDB2020:8576240SIGNOR:18923512Baccin2019:85762408576240HPRD:8576240Cellinker:8576240CellTalkDB:8576240 |
| NRX1A | Q9ULB1 | NLGN2 | Q8NFZ4 | Yes | Yes | No | CellChatDBCellPhoneDBSIGNORHPRDBaccin2019Ramilowski2015_Baccin2019Wang | HPRD:8576240SIGNOR:22626542SIGNOR:22626543 |
| NRX1B | P58400 | NLGN2 | Q8NFZ4 | Yes | Yes | No | CellChatDBCellPhoneDBSIGNORHPRDBaccin2019Ramilowski2015_Baccin2019Wang | HPRD:8576240SIGNOR:22626542SIGNOR:22626543 |
| NLGN2 | Q8NFZ4 | NRX1B | P58400 | Yes | Yes | No | iTALKSIGNORHPMR_talklrHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019CellinkerEMBRACECellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb | LRdb:8576240connectomeDB2020:8576240SIGNOR:18923512Baccin2019:85762408576240HPRD:8576240Cellinker:8576240CellTalkDB:8576240 |
| NLGN2 | Q8NFZ4 | NRX2A | Q9P2S2 | Yes | Yes | No | CellTalkDBFantom5_LRdbHPMR_LRdbiTALKCellPhoneDBHPMR_CellinkertalklrRamilowski2015SIGNORconnectomeDB2020Baccin2019Ramilowski2015_Baccin2019CellinkerWangLRdbEMBRACEHPMR_talklr | Baccin2019:8576240LRdb:8576240connectomeDB2020:8576240SIGNOR:18923512Cellinker:8576240CellTalkDB:8576240 |
| NRX2A | Q9P2S2 | NLGN2 | Q8NFZ4 | Yes | Yes | No | CellChatDBCellPhoneDBSIGNORBaccin2019Ramilowski2015_Baccin2019Wang | SIGNOR:22626544SIGNOR:22626545 |
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Protein Complex Composition (3)
Sequence, Structure & Domains11
Sequences
Length
835
Mass
90,820
Sequence
MWLLALCLVGLAGAQRGGGGPGGGAPGGPGLGLGSLGEERFPVVNTAYGRVRGVRRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPPDTDIRDPGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYGNVIVATLNYRLGVLGFLSTGDQAAKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTAISSWSVNYQPLKYTRLLAAKVGCDREDSAEAVECLRRKPSRELVDQDVQPARYHIAFGPVVDGDVVPDDPEILMQQGEFLNYDMLIGVNQGEGLKFVEDSAESEDGVSASAFDFTVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRDNGEMRRKTLLALFTDHQWVAPAVATAKLHADYQSPVYFYTFYHHCQAEGRPEWADAAHGDELPYVFGVPMVGATDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVVWSKFNSKEKQYLHIGLKPRVRDNYRANKVAFWLELVPHLHNLHTELFTTTTRLPPYATRWPPRPPAGAPGTRRPPPPATLPPEPEPEPGPRAYDRFPGDSRDYSTELSVTVAVGASLLFLNILAFAALYYKRDRRQELRCRRLSPPGGSGSGVPGGGPLLPAAGRELPPEEELVSLQLKRGGGVGADPAEALRPACPPDYTLALRRAPDDVPLLAPGALTLLPSGLGPPPPPPPPSLHPFGPFPPPPPTATSHNNTLPHPHSTTRV
3D Structural Models
Turn
81..84; 116..118; 279..283; 297..299; 500..503; 575..577; 604..607
Helix
121..125; 127..131; 132..134; 193..195; 199..205; 217..221; 233..246; 249..252; 266..276; 304..314; 322..329; 334..338; 364..369; 388..391; 403..417; 424..434; 438..440; 444..459; 461..473; 504..507; 510..512; 525..544; 595..603
Beta Strand
43..45; 50..52; 54..57; 61..63; 65..73; 94..98; 110..112; 135..137; 143..148; 177..183; 186..190; 208..212; 225..228; 254..264; 285..291; 294..296; 300..302; 350..352; 357..360; 377..383; 478..483; 517..519; 545..550; 580..586; 588..591
3D Structure
Electron microscopy (13); X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
630..658; Pro residues; 795..818; Pro residues; 823..835; Polar residues
Region
623..668; Disordered; 678..698; Required for interaction with LHFPL4; 790..835; Disordered
Protein Families
Type-B carboxylesterase/lipase family
Sequence Similarities
Belongs to the type-B carboxylesterase/lipase family.
Supporting Publications12
| PMID | Title | Abstract |
|---|---|---|
| 27312428 | A novel TP53 pathway influences the HGS-mediated exosome formation in colorectal cancer. | No abstract available |
| 29562735 | Altered Proteome of Extracellular Vesicles Derived from Bladder Cancer Patients Urine. | No abstract available |
| 31320591 | Exosomes regulate neurogenesis and circuit assembly. | No abstract available |
| 31508500 | Proteomic profiling of extracellular vesicles allows for human breast cancer subtyping. | No abstract available |
| 33718342 | Extracellular Vesicles Derived From Adult and Fetal Bone Marrow Mesenchymal Stromal Cells Differentially Promote ex vivo Expansion of Hematopoietic Stem and Progenitor Cells. | No abstract available |
| 37922300 | Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women. | No abstract available |
| 38321535 | Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles. | No abstract available |
| 39873726 | Size-Dependent Separation of Extracellular Vesicle Subtypes with Exodisc Enabling Proteomic Analysis in Prostate Cancer. | No abstract available |
| 39949490 | CRISPR-dCas9 Activation of TSG-6 in MSCs Modulates the Cargo of MSC-Derived Extracellular Vesicles and Attenuates Inflammatory Responses in Human Intervertebral Disc Cells In Vitro. | No abstract available |
| 40098346 | Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays. | No abstract available |
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