Protein detail

NLGN2

Neuroligin-2

Entry name NLGN2	UniProt ID Q8NFZ4	EVMP confidence score 0.60
Supporting publications (n) 12	Transmembrane count 1	Protein classification Predicted intracellular proteinsPredicted membrane proteinsTransporters

Basic Information

Protein Names

Neuroligin-2

Protein Class (3)

Predicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function (2)

Predicted intracellular proteins
Transporters:Accessory Factors Involved in Transport

Transmembrane

678..698; Helical

Transmembrane Count

Ensembl

ENSG00000169992

Entrez Gene Symbol

NLGN2

Gene Synonym

KIAA1366

Gene Description

Neuroligin 2

Chromosome

Position

7404874-7419860

Supporting publications (n)

EVMP confidence score

0.60

Fluorescence & Localization

Tissue Specificadrenal glandCell SpecificAdrenal cortex cellsSingle-Nuclei Brain Specifichippocampal CA1-3

Function & Pathway

Protein Function (2)

Predicted intracellular proteins
Transporters:Accessory Factors Involved in Transport

Cellular Component (15)

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Molecular Function (4)

Biological Process (3)

KEGG (2)

Reactome (3)

Mediation Categories (2)

Adhesion and uptake mediationFusion and delivery mediation

Relations & Evidence73

Ligand-Receptor Signaling (54)

54 records.

Category	Parent	Database	Transmitter	Receiver	Plasma Membrane (Transmembrane)
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	Yes
transmembrane	transmembrane	UniProt_location			Yes
transmembrane	transmembrane	UniProt_topology			Yes
transmembrane	transmembrane	UniProt_keyword			Yes
transmembrane_predicted	transmembrane	OmniPath			Yes
transmembrane	transmembrane	CellPhoneDB			Yes
transmembrane	transmembrane	TopDB			Yes
transmembrane	transmembrane	LOCATE			Yes
transmembrane	transmembrane	Ramilowski_location			Yes
transmembrane	transmembrane	OmniPath			Yes

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Regulatory Interaction Network (15)

15 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Database	References
NRX2B	P58401	NLGN2	Q8NFZ4	Yes	Yes	CellChatDBCellPhoneDBSIGNORBaccin2019Ramilowski2015_Baccin2019Wang	SIGNOR:22626544 SIGNOR:22626545
NLGN2	Q8NFZ4	NRX2B	P58401	Yes	Yes	CellTalkDBFantom5_LRdbHPMR_LRdbiTALKCellPhoneDBHPMR_CellinkertalklrRamilowski2015SIGNORconnectomeDB2020Baccin2019Ramilowski2015_Baccin2019CellinkerWangLRdbEMBRACEHPMR_talklr	Baccin2019:8576240 LRdb:8576240 connectomeDB2020:8576240 SIGNOR:18923512 Cellinker:8576240 CellTalkDB:8576240
GEPH	Q9NQX3	NLGN2	Q8NFZ4	Yes	Yes	SIGNOR	SIGNOR:25882190
NLGN2	Q8NFZ4	MAGI2	Q86UL8	Yes	Yes	SIGNOR	SIGNOR:22626542
NLGN2	Q8NFZ4	DLG4	P78352	Yes	Yes	HPRDSIGNOR	SIGNOR:18923512 HPRD:9278515

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Protein Complex Composition (3)

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
GABRG2 LHFPL4 NLGN2	P18507 Q7Z7J7 Q8NFZ4	1:1:1	PDB	PDB:9farPDB:9fan
NLGN2	Q8NFZ4	2	PDB	PDB:8gs4
NLGN2 NRXN2 PATJ	Q8NFZ4 Q8NI35 Q9P2S2	1:1:1	CompleatCFinder	Compleat:HC4773

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometryWestern blottingFlow cytometryRNA Sequencing	2	33709510 40098346

Sequence, Structure & Domains

Sequences

Length

835

Mass

90,820

Sequence

MWLLALCLVGLAGAQRGGGGPGGGAPGGPGLGLGSLGEERFPVVNTAYGRVRGVRRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPPDTDIRDPGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYGNVIVATLNYRLGVLGFLSTGDQAAKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTAISSWSVNYQPLKYTRLLAAKVGCDREDSAEAVECLRRKPSRELVDQDVQPARYHIAFGPVVDGDVVPDDPEILMQQGEFLNYDMLIGVNQGEGLKFVEDSAESEDGVSASAFDFTVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRDNGEMRRKTLLALFTDHQWVAPAVATAKLHADYQSPVYFYTFYHHCQAEGRPEWADAAHGDELPYVFGVPMVGATDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVVWSKFNSKEKQYLHIGLKPRVRDNYRANKVAFWLELVPHLHNLHTELFTTTTRLPPYATRWPPRPPAGAPGTRRPPPPATLPPEPEPEPGPRAYDRFPGDSRDYSTELSVTVAVGASLLFLNILAFAALYYKRDRRQELRCRRLSPPGGSGSGVPGGGPLLPAAGRELPPEEELVSLQLKRGGGVGADPAEALRPACPPDYTLALRRAPDDVPLLAPGALTLLPSGLGPPPPPPPPSLHPFGPFPPPPPTATSHNNTLPHPHSTTRV

3D Structural Models

Turn

81..84; 116..118; 279..283; 297..299; 500..503; 575..577; 604..607

Helix

121..125; 127..131; 132..134; 193..195; 199..205; 217..221; 233..246; 249..252; 266..276; 304..314; 322..329; 334..338; 364..369; 388..391; 403..417; 424..434; 438..440; 444..459; 461..473; 504..507; 510..512; 525..544; 595..603

Beta Strand

43..45; 50..52; 54..57; 61..63; 65..73; 94..98; 110..112; 135..137; 143..148; 177..183; 186..190; 208..212; 225..228; 254..264; 285..291; 294..296; 300..302; 350..352; 357..360; 377..383; 478..483; 517..519; 545..550; 580..586; 588..591

3D Structure

Electron microscopy (13); X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

630..658; Pro residues; 795..818; Pro residues; 823..835; Polar residues

Region

623..668; Disordered; 678..698; Required for interaction with LHFPL4; 790..835; Disordered

Protein Families

Type-B carboxylesterase/lipase family

Sequence Similarities

Belongs to the type-B carboxylesterase/lipase family.

Clinical Relevance

Antibody (2)

HPA055321 HPA069278

Supporting Publications12

PMID	Title	Related sentences
27312428	A novel TP53 pathway influences the HGS-mediated exosome formation in colorectal cancer.	No related sentences available
29562735	Altered Proteome of Extracellular Vesicles Derived from Bladder Cancer Patients Urine.	No related sentences available
31320591	Exosomes regulate neurogenesis and circuit assembly.	No related sentences available
31508500	Proteomic profiling of extracellular vesicles allows for human breast cancer subtyping.	No related sentences available
33718342	Extracellular Vesicles Derived From Adult and Fetal Bone Marrow Mesenchymal Stromal Cells Differentially Promote ex vivo Expansion of Hematopoietic Stem and Progenitor Cells.	No related sentences available
37922300	Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women.	No related sentences available
38321535	Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles.	No related sentences available
39873726	Size-Dependent Separation of Extracellular Vesicle Subtypes with Exodisc Enabling Proteomic Analysis in Prostate Cancer.	No related sentences available
39949490	CRISPR-dCas9 Activation of TSG-6 in MSCs Modulates the Cargo of MSC-Derived Extracellular Vesicles and Attenuates Inflammatory Responses in Human Intervertebral Disc Cells In Vitro.	No related sentences available
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No related sentences available

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