Protein detail

NLGN2

Neuroligin-2

Entry name NLGN2	UniProt ID Q8NFZ4	EVMP score 0.47
Frequency 12	Transmembrane count 1	Protein classification Predicted intracellular proteinsPredicted membrane proteinsTransporters

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Neuroligin-2

Protein Class

Predicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function

Predicted intracellular proteins
Transporters:Accessory Factors Involved in Transport

Transmembrane

678..698; Helical

Transmembrane Count

Ensembl

ENSG00000169992

Entrez Gene Symbol

NLGN2

Gene Synonym

KIAA1366

Gene Description

Neuroligin 2

Chromosome

Position

7404874-7419860

Frequency

EVMP Score

0.47

Fluorescence & Localization

Tissue Specificadrenal glandCell SpecificAdrenal cortex cellsSingle-Nuclei Brain Specifichippocampal CA1-3

Function & Pathway

Protein Function

Predicted intracellular proteins
Transporters:Accessory Factors Involved in Transport

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Adhesion and uptake mediationFusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

54 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	Cellinker	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	connectomeDB2020	No	No	No	Yes	No
cell_surface	cell_surface	Baccin2019	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No

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Regulatory Interaction Network

15 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
NRX2B	P58401	NLGN2	Q8NFZ4	Yes	Yes	No	CellChatDBCellPhoneDBSIGNORBaccin2019Ramilowski2015_Baccin2019Wang	SIGNOR:22626544 SIGNOR:22626545
NLGN2	Q8NFZ4	NRX2B	P58401	Yes	Yes	No	CellTalkDBFantom5_LRdbHPMR_LRdbiTALKCellPhoneDBHPMR_CellinkertalklrRamilowski2015SIGNORconnectomeDB2020Baccin2019Ramilowski2015_Baccin2019CellinkerWangLRdbEMBRACEHPMR_talklr	Baccin2019:8576240 LRdb:8576240 connectomeDB2020:8576240 SIGNOR:18923512 Cellinker:8576240 CellTalkDB:8576240
GEPH	Q9NQX3	NLGN2	Q8NFZ4	Yes	Yes	No	SIGNOR	SIGNOR:25882190
NLGN2	Q8NFZ4	MAGI2	Q86UL8	Yes	Yes	No	SIGNOR	SIGNOR:22626542
NLGN2	Q8NFZ4	DLG4	P78352	Yes	Yes	No	HPRDSIGNOR	SIGNOR:18923512 HPRD:9278515

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Protein Complex Composition

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
GABRG2 LHFPL4 NLGN2	P18507 Q7Z7J7 Q8NFZ4	1:1:1	PDB	PDB:9farPDB:9fan
NLGN2	Q8NFZ4	2	PDB	PDB:8gs4
NLGN2 NRXN2 PATJ	Q8NFZ4 Q8NI35 Q9P2S2	1:1:1	CompleatCFinder	Compleat:HC4773

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometryWestern blottingFlow cytometryRNA Sequencing	2	33709510 40098346

Sequence, Structure & Domains

Sequences

Length

835

Mass

90,820

Sequence

MWLLALCLVGLAGAQRGGGGPGGGAPGGPGLGLGSLGEERFPVVNTAYGRVRGVRRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPPDTDIRDPGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYGNVIVATLNYRLGVLGFLSTGDQAAKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTAISSWSVNYQPLKYTRLLAAKVGCDREDSAEAVECLRRKPSRELVDQDVQPARYHIAFGPVVDGDVVPDDPEILMQQGEFLNYDMLIGVNQGEGLKFVEDSAESEDGVSASAFDFTVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRDNGEMRRKTLLALFTDHQWVAPAVATAKLHADYQSPVYFYTFYHHCQAEGRPEWADAAHGDELPYVFGVPMVGATDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVVWSKFNSKEKQYLHIGLKPRVRDNYRANKVAFWLELVPHLHNLHTELFTTTTRLPPYATRWPPRPPAGAPGTRRPPPPATLPPEPEPEPGPRAYDRFPGDSRDYSTELSVTVAVGASLLFLNILAFAALYYKRDRRQELRCRRLSPPGGSGSGVPGGGPLLPAAGRELPPEEELVSLQLKRGGGVGADPAEALRPACPPDYTLALRRAPDDVPLLAPGALTLLPSGLGPPPPPPPPSLHPFGPFPPPPPTATSHNNTLPHPHSTTRV

3D Structural Models

Turn

81..84; 116..118; 279..283; 297..299; 500..503; 575..577; 604..607

Helix

121..125; 127..131; 132..134; 193..195; 199..205; 217..221; 233..246; 249..252; 266..276; 304..314; 322..329; 334..338; 364..369; 388..391; 403..417; 424..434; 438..440; 444..459; 461..473; 504..507; 510..512; 525..544; 595..603

Beta Strand

43..45; 50..52; 54..57; 61..63; 65..73; 94..98; 110..112; 135..137; 143..148; 177..183; 186..190; 208..212; 225..228; 254..264; 285..291; 294..296; 300..302; 350..352; 357..360; 377..383; 478..483; 517..519; 545..550; 580..586; 588..591

3D Structure

Electron microscopy (13); X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

630..658; Pro residues; 795..818; Pro residues; 823..835; Polar residues

Region

623..668; Disordered; 678..698; Required for interaction with LHFPL4; 790..835; Disordered

Protein Families

Type-B carboxylesterase/lipase family

Sequence Similarities

Belongs to the type-B carboxylesterase/lipase family.

Clinical Relevance

Antibody

HPA055321 HPA069278