Protein detail

NLGN2

Neuroligin-2

Entry name NLGN2	UniProt ID Q8NFZ4	EVMP confidence score 0.60
Supporting publications (n) 12	Transmembrane count 1	Protein classification Predicted intracellular proteinsPredicted membrane proteinsTransporters

Basic Information

Protein Names

Neuroligin-2

Protein Class (3)

Predicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function (2)

Predicted intracellular proteins
Transporters:Accessory Factors Involved in Transport

Transmembrane

678..698; Helical

Transmembrane Count

Ensembl

ENSG00000169992

Entrez Gene Symbol

NLGN2

Gene Synonym

KIAA1366

Gene Description

Neuroligin 2

Chromosome

Position

7404874-7419860

Supporting publications (n)

EVMP confidence score

0.60

Fluorescence & Localization

Tissue Specificadrenal glandCell SpecificAdrenal cortex cellsSingle-Nuclei Brain Specifichippocampal CA1-3

Function & Pathway

Protein Function (2)

Predicted intracellular proteins
Transporters:Accessory Factors Involved in Transport

Cellular Component (15)

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Molecular Function (4)

Biological Process (3)

KEGG (2)

Reactome (3)

Mediation Categories (2)

Adhesion and uptake mediationFusion and delivery mediation

Relations & Evidence73

Ligand-Receptor Signaling (54)

54 records.

Category	Parent	Database	Transmitter	Receiver	Plasma Membrane (Transmembrane)
ligand	ligand	talklr	Yes		Yes
ligand	ligand	iTALK	Yes		Yes
ligand	ligand	EMBRACE	Yes		Yes
ligand	ligand	CellTalkDB	Yes		Yes
ligand	ligand	Ramilowski2015	Yes		Yes
ligand	ligand	LRdb	Yes		Yes
ligand	ligand	Almen2009	Yes		Yes
neuroligin	ligand	Almen2009	Yes		Yes
ligand	ligand	OmniPath	Yes		Yes
receptor	receptor	CellCellInteractions		Yes	Yes

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Regulatory Interaction Network (15)

15 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Database	References
NLGN2	Q8NFZ4	NRX3B	Q9HDB5	Yes	Yes	CellTalkDBFantom5_LRdbHPMR_LRdbiTALKCellPhoneDBHPMR_CellinkertalklrRamilowski2015SIGNORconnectomeDB2020CellinkerWangLRdbHPMR_talklr	LRdb:8576240 connectomeDB2020:8576240 SIGNOR:18923512 Cellinker:8576240 CellTalkDB:8576240
NRX3B	Q9HDB5	NLGN2	Q8NFZ4	Yes	Yes	CellPhoneDBCellChatDBWangSIGNOR	SIGNOR:22626546 SIGNOR:22626547
NLGN2	Q8NFZ4	NRX3A	Q9Y4C0	Yes	Yes	CellTalkDBFantom5_LRdbHPMR_LRdbiTALKCellPhoneDBHPMR_CellinkertalklrRamilowski2015SIGNORconnectomeDB2020CellinkerWangLRdbHPMR_talklr	LRdb:8576240 connectomeDB2020:8576240 SIGNOR:18923512 Cellinker:8576240 CellTalkDB:8576240
NRX3A	Q9Y4C0	NLGN2	Q8NFZ4	Yes	Yes	CellPhoneDBCellChatDBWangSIGNOR	SIGNOR:22626546 SIGNOR:22626547
NLGN2	Q8NFZ4	NRX1A	Q9ULB1	Yes	Yes	iTALKSIGNORHPMR_talklrHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019CellinkerEMBRACECellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	LRdb:8576240 connectomeDB2020:8576240 SIGNOR:18923512Baccin2019:85762408576240HPRD:8576240 Cellinker:8576240 CellTalkDB:8576240
NRX1A	Q9ULB1	NLGN2	Q8NFZ4	Yes	Yes	CellChatDBCellPhoneDBSIGNORHPRDBaccin2019Ramilowski2015_Baccin2019Wang	HPRD:8576240 SIGNOR:22626542 SIGNOR:22626543
NRX1B	P58400	NLGN2	Q8NFZ4	Yes	Yes	CellChatDBCellPhoneDBSIGNORHPRDBaccin2019Ramilowski2015_Baccin2019Wang	HPRD:8576240 SIGNOR:22626542 SIGNOR:22626543
NLGN2	Q8NFZ4	NRX1B	P58400	Yes	Yes	iTALKSIGNORHPMR_talklrHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019CellinkerEMBRACECellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	LRdb:8576240 connectomeDB2020:8576240 SIGNOR:18923512Baccin2019:85762408576240HPRD:8576240 Cellinker:8576240 CellTalkDB:8576240
NLGN2	Q8NFZ4	NRX2A	Q9P2S2	Yes	Yes	CellTalkDBFantom5_LRdbHPMR_LRdbiTALKCellPhoneDBHPMR_CellinkertalklrRamilowski2015SIGNORconnectomeDB2020Baccin2019Ramilowski2015_Baccin2019CellinkerWangLRdbEMBRACEHPMR_talklr	Baccin2019:8576240 LRdb:8576240 connectomeDB2020:8576240 SIGNOR:18923512 Cellinker:8576240 CellTalkDB:8576240
NRX2A	Q9P2S2	NLGN2	Q8NFZ4	Yes	Yes	CellChatDBCellPhoneDBSIGNORBaccin2019Ramilowski2015_Baccin2019Wang	SIGNOR:22626544 SIGNOR:22626545

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Protein Complex Composition (3)

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
GABRG2 LHFPL4 NLGN2	P18507 Q7Z7J7 Q8NFZ4	1:1:1	PDB	PDB:9farPDB:9fan
NLGN2	Q8NFZ4	2	PDB	PDB:8gs4
NLGN2 NRXN2 PATJ	Q8NFZ4 Q8NI35 Q9P2S2	1:1:1	CompleatCFinder	Compleat:HC4773

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometryWestern blottingFlow cytometryRNA Sequencing	2	33709510 40098346

Sequence, Structure & Domains

Sequences

Length

835

Mass

90,820

Sequence

MWLLALCLVGLAGAQRGGGGPGGGAPGGPGLGLGSLGEERFPVVNTAYGRVRGVRRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPPDTDIRDPGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYGNVIVATLNYRLGVLGFLSTGDQAAKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTAISSWSVNYQPLKYTRLLAAKVGCDREDSAEAVECLRRKPSRELVDQDVQPARYHIAFGPVVDGDVVPDDPEILMQQGEFLNYDMLIGVNQGEGLKFVEDSAESEDGVSASAFDFTVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRDNGEMRRKTLLALFTDHQWVAPAVATAKLHADYQSPVYFYTFYHHCQAEGRPEWADAAHGDELPYVFGVPMVGATDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVVWSKFNSKEKQYLHIGLKPRVRDNYRANKVAFWLELVPHLHNLHTELFTTTTRLPPYATRWPPRPPAGAPGTRRPPPPATLPPEPEPEPGPRAYDRFPGDSRDYSTELSVTVAVGASLLFLNILAFAALYYKRDRRQELRCRRLSPPGGSGSGVPGGGPLLPAAGRELPPEEELVSLQLKRGGGVGADPAEALRPACPPDYTLALRRAPDDVPLLAPGALTLLPSGLGPPPPPPPPSLHPFGPFPPPPPTATSHNNTLPHPHSTTRV

3D Structural Models

Turn

81..84; 116..118; 279..283; 297..299; 500..503; 575..577; 604..607

Helix

121..125; 127..131; 132..134; 193..195; 199..205; 217..221; 233..246; 249..252; 266..276; 304..314; 322..329; 334..338; 364..369; 388..391; 403..417; 424..434; 438..440; 444..459; 461..473; 504..507; 510..512; 525..544; 595..603

Beta Strand

43..45; 50..52; 54..57; 61..63; 65..73; 94..98; 110..112; 135..137; 143..148; 177..183; 186..190; 208..212; 225..228; 254..264; 285..291; 294..296; 300..302; 350..352; 357..360; 377..383; 478..483; 517..519; 545..550; 580..586; 588..591

3D Structure

Electron microscopy (13); X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

630..658; Pro residues; 795..818; Pro residues; 823..835; Polar residues

Region

623..668; Disordered; 678..698; Required for interaction with LHFPL4; 790..835; Disordered

Protein Families

Type-B carboxylesterase/lipase family

Sequence Similarities

Belongs to the type-B carboxylesterase/lipase family.

Clinical Relevance

Antibody (2)

HPA055321 HPA069278

Supporting Publications12

PMID	Title	Related sentences
27312428	A novel TP53 pathway influences the HGS-mediated exosome formation in colorectal cancer.	No related sentences available
29562735	Altered Proteome of Extracellular Vesicles Derived from Bladder Cancer Patients Urine.	No related sentences available
31320591	Exosomes regulate neurogenesis and circuit assembly.	No related sentences available
31508500	Proteomic profiling of extracellular vesicles allows for human breast cancer subtyping.	No related sentences available
33718342	Extracellular Vesicles Derived From Adult and Fetal Bone Marrow Mesenchymal Stromal Cells Differentially Promote ex vivo Expansion of Hematopoietic Stem and Progenitor Cells.	No related sentences available
37922300	Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women.	No related sentences available
38321535	Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles.	No related sentences available
39873726	Size-Dependent Separation of Extracellular Vesicle Subtypes with Exodisc Enabling Proteomic Analysis in Prostate Cancer.	No related sentences available
39949490	CRISPR-dCas9 Activation of TSG-6 in MSCs Modulates the Cargo of MSC-Derived Extracellular Vesicles and Attenuates Inflammatory Responses in Human Intervertebral Disc Cells In Vitro.	No related sentences available
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No related sentences available

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