Protein detail

IL31R

Interleukin-31 receptor subunit alpha (IL-31 receptor subunit alpha) (IL-31R subunit alpha) (IL-31R-alpha) (IL-31RA) (Cytokine receptor-like 3) (GLM-R) (hGLM-R) (Gp130-like monocyte receptor) (Gp130-like receptor) (ZcytoR17)

Entry name IL31R	UniProt ID Q8NI17	EVMP score 0.50
Frequency 1	Transmembrane count 1	Protein classification Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Protein Class

Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins

Protein Function

Disease related genes
Human disease related genes:Skin diseases:Skin and soft tissue diseases
Predicted intracellular proteins

Transmembrane

520..540; Helical

Transmembrane Count

Ensembl

ENSG00000164509

Entrez Gene Symbol

IL31RA

Gene Synonym

CRLCRL3GLM-RGlmrIL-31RA

Gene Description

Interleukin 31 receptor A

Chromosome

Position

55851357-55922854

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue SpecificintestineCell SpecificColonocytesSecretome LocationSecreted to digestive systemSecretome FunctionNo annotated function

Function & Pathway

Protein Function

Disease related genes
Human disease related genes:Skin diseases:Skin and soft tissue diseases
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Fusion and delivery mediationImmune mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

58 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
cytokine_type_1	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	HPMR	No	No	No	Yes	No
extracellular	extracellular	DGIdb	No	No	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	LOCATE	No	No	No	Yes	No
intracellular	intracellular	ComPPI	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No

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Regulatory Interaction Network

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
IL31R	Q8NI17	JAK2	O60674	Yes	Yes	No	SIGNORSignaLink3	SignaLink3:18926762 SignaLink3:23331499 SIGNOR:18926762
IL31	Q6EBC2	IL31R	Q8NI17	Yes	Yes	No	iTALKSIGNORSignaLink3UniProt_LRdbHPMR_talklrHPMRtalklrscConnectRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbBaccin2019EMBRACEGuide2PharmaFantom5_LRdbCellTalkDBconnectomeDB2020LRdb	connectomeDB2020:15184896 CellTalkDB:15184896 HPMR:15194700 Baccin2019:15184896 HPMR:15184896 SignaLink3:15184896 SIGNOR:15184896 LRdb:15184896 SignaLink3:23331499
IL31R	Q8NI17	JAK1	P23458	Yes	Yes	No	SIGNORSignaLink3	SignaLink3:18926762 SignaLink3:23331499 SIGNOR:18926762

Protein Complex Composition

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
IL31RA NTHL1	P78549 Q8NI17	0:0	hu.MAP2
IL31RA	Q8NI17	2	PDB	PDB:9eza
IL31RA OSMR	Q8NI17 Q99650	0:0	Guide2PharmaCellChatDBKEGG-MEDICUSICELLNETCellinker		18926762

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	7	39558134 29148239 39766158 36398564 39940923 38321535 39569406

Sequence, Structure & Domains

Sequences

Length

732

Mass

82,954

Sequence

MMWTWALWMLPSLCKFSLAALPAKPENISCVYYYRKNLTCTWSPGKETSYTQYTVKRTYAFGEKHDNCTTNSSTSENRASCSFFLPRITIPDNYTIEVEAENGDGVIKSHMTYWRLENIAKTEPPKIFRVKPVLGIKRMIQIEWIKPELAPVSSDLKYTLRFRTVNSTSWMEVNFAKNRKDKNQTYNLTGLQPFTEYVIALRCAVKESKFWSDWSQEKMGMTEEEAPCGLELWRVLKPAEADGRRPVRLLWKKARGAPVLEKTLGYNIWYYPESNTNLTETMNTTNQQLELHLGGESFWVSMISYNSLGKSPVATLRIPAIQEKSFQCIEVMQACVAEDQLVVKWQSSALDVNTWMIEWFPDVDSEPTTLSWESVSQATNWTIQQDKLKPFWCYNISVYPMLHDKVGEPYSIQAYAKEGVPSEGPETKVENIGVKTVTITWKEIPKSERKGIICNYTIFYQAEGGKGFSKTVNSSILQYGLESLKRKTSYIVQVMASTSAGGTNGTSINFKTLSFSVFEIILITSLIGGGLLILIILTVAYGLKKPNKLTHLCWPTVPNPAESSIATWHGDDFKDKLNLKESDDSVNTEDRILKPCSTPSDKLVIDKLVVNFGNVLQEIFTDEARTGQENNLGGEKNGYVTCPFRPDCPLGKSFEELPVSPEIPPRKSQYLRSRMPEGTRPEAKEQLLFSGQSLVPDHLCEEGAPNPYLKNSVTAREFLVSEKLPEHTKGEV

Alternative Products

Event=Alternative splicing; Named isoforms=12; Name=1; IsoId=Q8NI17-1; Sequence=Displayed; Name=2; Synonyms=v3; IsoId=Q8NI17-2; Sequence=VSP_022799; Name=3; Synonyms=v4; IsoId=Q8NI17-3; Sequence=VSP_022800, VSP_022812, VSP_022813; Name=4; Synonyms=v2; IsoId=Q8NI17-4; Sequence=VSP_022799, VSP_022801; Name=5; Synonyms=v1; IsoId=Q8NI17-5; Sequence=VSP_022799, VSP_022812, VSP_022813; Name=6; IsoId=Q8NI17-6; Sequence=VSP_022798; Name=7; IsoId=Q8NI17-7; Sequence=VSP_022800, VSP_022802, VSP_022804, VSP_022805; Name=8; IsoId=Q8NI17-8; Sequence=VSP_022799, VSP_022803, VSP_022807; Name=9; Synonyms=GPL560, short; IsoId=Q8NI17-9; Sequence=VSP_022800, VSP_022806; Name=10; Synonyms=GPL610; IsoId=Q8NI17-10; Sequence=VSP_022800, VSP_022809, VSP_022810; Name=11; Synonyms=GPL626; IsoId=Q8NI17-11; Sequence=VSP_022800, VSP_022808, VSP_022811; Name=12; Synonyms=GPL745, long; IsoId=Q8NI17-12; Sequence=VSP_022800

Alternative Sequence

1..110; Missing (in isoform 6); 1; M -> MCIRQLKFFTTACVCECPQNILSPQPSCVNLGM (in isoform 2, isoform 4, isoform 5 and isoform 8); 1; M -> MKLSPQPSCVNLGM (in isoform 3, isoform 7, isoform 9, isoform 10, isoform 11 and isoform 12); 325..732; Missing (in isoform 4); 464..469; GGKGFS -> A (in isoform 7); 469..550; SKTVNSSILQYGLESLKRKTSYIVQVMASTSAGGTNGTSINFKTLSFSVFEIILITSLIGGGLLILIILTVAYGLKKPNKLT -> CKHAHSEVEKNPKPQIDAMDRPVVGMAPPSHCDLQPGMNHLASLNLSENGAKSTHLLGFWGLNESEVTVPERRVLRKWKELL (in isoform 8); 498..501; TSAG -> YSGG (in isoform 7); 502..732; Missing (in isoform 7); 548..732; Missing (in isoform 9); 551..732; Missing (in isoform 8); 593..613; LKPCSTPSDKLVIDKLVVNFG -> KGSELGTKLKFKPLISLDCAF (in isoform 11); 593..598; LKPCST -> RARYQA (in isoform 10); 599..732; Missing (in isoform 10); 614..732; Missing (in isoform 11); 639..649; YVTCPFRPDCP -> TRILSSCPTSI (in isoform 3 and isoform 5); 650..732; Missing (in isoform 3 and isoform 5)

3D Structural Models

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Domain (FT)

24..122; Fibronectin type-III 1; 124..225; Fibronectin type-III 2; 223..315; Fibronectin type-III 3; 319..416; Fibronectin type-III 4; 421..515; Fibronectin type-III 5

Protein Families

Type I cytokine receptor family
Type 2 subfamily

Sequence Similarities

Belongs to the type I cytokine receptor family. Type 2 subfamily.

Clinical Relevance

Disease Involvement

AmyloidosisDisease variant

Drugs

NEMOLIZUMAB

Antibody

HPA068114