Protein detail

PCD19

Protocadherin-19

Entry name PCD19	UniProt ID Q8TAB3	EVMP confidence score 0.25
Supporting publications (n) 2	Transmembrane count 1	Protein classification Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Protocadherin-19

Protein Class (4)

Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins

Protein Function (3)

Human disease related genes:Nervous system diseases:Epilepsy
Disease related genes
Predicted intracellular proteins

Transmembrane

679..699; Helical

Transmembrane Count

Ensembl

ENSG00000165194

Entrez Gene Symbol

PCDH19

Gene Synonym (3)

EFMREIEE9KIAA1313

Gene Description

Protocadherin 19

Chromosome

Position

100291644-100410273

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization2

Tissue SpecificbrainCell SpecificBrain excitatory neurons

Function & Pathway8

Protein Function (3)

Human disease related genes:Nervous system diseases:Epilepsy
Disease related genes
Predicted intracellular proteins

Cellular Component

GO:0005886 plasma membrane

Molecular Function

GO:0005509 calcium ion binding

Biological Process (3)

KEGG

hsa04519 Cadherin signaling

Reactome (2)

Canonical Pathways

M145 Pid p53 downstream pathway

Mediation Categories

Adhesion and uptake mediation

Relations & Evidence36

Ligand-Receptor Signaling (29)

29 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
adhesion	adhesion	OmniPath	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane_predicted	transmembrane	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	TopDB	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No

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Regulatory Interaction Network (6)

6 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PCD19	Q8TAB3	GBRA1	P14867	Yes	Yes	No	SIGNOR	SIGNOR:29360992
PCD19	Q8TAB3	GBRA6	Q16445	Yes	Yes	No	SIGNOR	SIGNOR:29360992
PCD19	Q8TAB3	GBRA4	P48169	Yes	Yes	No	SIGNOR	SIGNOR:29360992
PCD19	Q8TAB3	GBRA2	P47869	Yes	Yes	No	SIGNOR	SIGNOR:29360992
PCD19	Q8TAB3	GBRA3	P34903	Yes	Yes	No	SIGNOR	SIGNOR:29360992
PCD19	Q8TAB3	GBRA5	P31644	Yes	Yes	No	SIGNOR	SIGNOR:29360992

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	40222457

Sequence, Structure & Domains12

Sequences

Length

1,148

Mass

126,253

Sequence

MESLLLPVLLLLAILWTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASAFRVVSNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVMSSSMEICVIKVEIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKTRGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSESTYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSESAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRLQEYESFSTILVDGRLDREQHDQYNLTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGYLVTVVKAEDYDEGENGRVTYDMTEGDRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSASALVLIYLSPALDAQESMGSVNLSLIFIIALGSIAGILFVTMIFVAIKCKRDNKEIRTYNCSNCLTITCLLGCFIKGQNSKCLHCISVSPISEEQDKKTEEKVSLRGKRIAEYSYGHQKKSSKKKKISKNDIRLVPRDVEETDKMNVVSCSSLTSSLNYFDYHQQTLPLGCRRSESTFLNVENQNTRNTSANHIYHHSFNSQGPQQPDLIINGVPLPETENYSFDSNYVNSRAHLIKSSSTFKDLEGNSLKDSGHEESDQTDSEHDVQRSLYCDTAVNDVLNTSVTSMGSQMPDHDQNEGFHCREECRILGHSDRCWMPRNPMPIRSKSPEHVRNIIALSIEATAADVEAYDDCGPTKRTFATFGKDVSDHPAEERPTLKGKRTVDVTICSPKVNSVIREAGNGCEAISPVTSPLHLKSSLPTKPSVSYTIALAPPARDLEQYVNNVNNGPTRPSEAEPRGADSEKVMHEVSPILKEGRNKESPGVKRLKDIVL

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8TAB3-1; Sequence=Displayed; Name=2; IsoId=Q8TAB3-2; Sequence=VSP_015081; Name=3; IsoId=Q8TAB3-3; Sequence=VSP_015081, VSP_054046

Alternative Sequence

716..762; Missing (in isoform 2 and isoform 3); 892; Missing (in isoform 3)

3D Structural Models

Turn

69..71; 76..78; 198..200; 293..295; 306..308; 413..415

Helix

42..49; 89..92; 159..161; 268..271; 284..288; 379..381

Beta Strand

23..32; 38..40; 61..67; 72..74; 81..85; 100..107; 112..120; 130..139; 147..149; 162..168; 172..184; 186..192; 203..212; 219..229; 237..239; 241..248; 253..259; 273..277; 289..291; 297..300; 310..324; 328..337; 345..349; 356..361; 367..374; 384..388; 393..399; 402..407; 417..431; 434..445

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

906..921; Basic and acidic residues; 1109..1123; Basic and acidic residues; 1130..1148; Basic and acidic residues

Domain (FT)

22..129; Cadherin 1; 130..238; Cadherin 2; 239..346; Cadherin 3; 350..453; Cadherin 4; 454..563; Cadherin 5; 569..672; Cadherin 6

Region

901..921; Disordered; 1100..1148; Disordered

Clinical Relevance2

Disease Involvement (3)

Disease variantEpilepsyIntellectual disability

Antibody

HPA027533

Supporting Publications2

PMID	Title	Abstract
30865381	Surfaceome of Exosomes Secreted from the Colorectal Cancer Cell Line SW480: Peripheral and Integral Membrane Proteins Analyzed by Proteolysis and TX114.	No abstract available
32384937	Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles.	No abstract available