Protein detail
PCD19
Protocadherin-19
Entry name PCD19 | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 2 | Transmembrane count 1 | Protein classification Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Protocadherin-19
Protein Class (4)
Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins
Protein Function (3)
- Human disease related genes:Nervous system diseases:Epilepsy
- Disease related genes
- Predicted intracellular proteins
Transmembrane
679..699; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
EFMREIEE9KIAA1313
Gene Description
Protocadherin 19
Chromosome
X
Position
100291644-100410273
Supporting publications (n)
2
EVMP confidence score
0.40
Fluorescence & Localization
Tissue SpecificbrainCell SpecificBrain excitatory neurons
Function & Pathway
Protein Function (3)
- Human disease related genes:Nervous system diseases:Epilepsy
- Disease related genes
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process (3)
Canonical Pathways
M145 Pid p53 downstream pathway
Mediation Categories
Adhesion and uptake mediation
Relations & Evidence36
Ligand-Receptor Signaling (29)
29 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| adhesion | adhesion | OmniPath | Yes | Yes | Yes | ||
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | Yes | ||
| transmembrane | transmembrane | UniProt_location | Yes | ||||
| transmembrane | transmembrane | UniProt_topology | Yes | ||||
| transmembrane | transmembrane | UniProt_keyword | Yes | ||||
| transmembrane_predicted | transmembrane | OmniPath | Yes | ||||
| transmembrane | transmembrane | TopDB | Yes | ||||
| transmembrane | transmembrane | Ramilowski_location | Yes | ||||
| transmembrane | transmembrane | OmniPath | Yes | ||||
| plasma_membrane | plasma_membrane | UniProt_location | Yes |
Regulatory Interaction Network (6)
6 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PCD19 | Q8TAB3 | GBRA1 | P14867 | Yes | Yes | SIGNOR | SIGNOR:29360992 | |
| PCD19 | Q8TAB3 | GBRA6 | Q16445 | Yes | Yes | SIGNOR | SIGNOR:29360992 | |
| PCD19 | Q8TAB3 | GBRA4 | P48169 | Yes | Yes | SIGNOR | SIGNOR:29360992 | |
| PCD19 | Q8TAB3 | GBRA2 | P47869 | Yes | Yes | SIGNOR | SIGNOR:29360992 | |
| PCD19 | Q8TAB3 | GBRA3 | P34903 | Yes | Yes | SIGNOR | SIGNOR:29360992 | |
| PCD19 | Q8TAB3 | GBRA5 | P31644 | Yes | Yes | SIGNOR | SIGNOR:29360992 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 40222457 |
Sequence, Structure & Domains
Sequences
Length
1,148
Mass
126,253
Sequence
MESLLLPVLLLLAILWTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASAFRVVSNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVMSSSMEICVIKVEIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKTRGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSESTYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSESAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRLQEYESFSTILVDGRLDREQHDQYNLTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGYLVTVVKAEDYDEGENGRVTYDMTEGDRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSASALVLIYLSPALDAQESMGSVNLSLIFIIALGSIAGILFVTMIFVAIKCKRDNKEIRTYNCSNCLTITCLLGCFIKGQNSKCLHCISVSPISEEQDKKTEEKVSLRGKRIAEYSYGHQKKSSKKKKISKNDIRLVPRDVEETDKMNVVSCSSLTSSLNYFDYHQQTLPLGCRRSESTFLNVENQNTRNTSANHIYHHSFNSQGPQQPDLIINGVPLPETENYSFDSNYVNSRAHLIKSSSTFKDLEGNSLKDSGHEESDQTDSEHDVQRSLYCDTAVNDVLNTSVTSMGSQMPDHDQNEGFHCREECRILGHSDRCWMPRNPMPIRSKSPEHVRNIIALSIEATAADVEAYDDCGPTKRTFATFGKDVSDHPAEERPTLKGKRTVDVTICSPKVNSVIREAGNGCEAISPVTSPLHLKSSLPTKPSVSYTIALAPPARDLEQYVNNVNNGPTRPSEAEPRGADSEKVMHEVSPILKEGRNKESPGVKRLKDIVL
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8TAB3-1; Sequence=Displayed; Name=2; IsoId=Q8TAB3-2; Sequence=VSP_015081; Name=3; IsoId=Q8TAB3-3; Sequence=VSP_015081, VSP_054046
Alternative Sequence
716..762; Missing (in isoform 2 and isoform 3); 892; Missing (in isoform 3)
3D Structural Models
Turn
69..71; 76..78; 198..200; 293..295; 306..308; 413..415
Helix
42..49; 89..92; 159..161; 268..271; 284..288; 379..381
Beta Strand
23..32; 38..40; 61..67; 72..74; 81..85; 100..107; 112..120; 130..139; 147..149; 162..168; 172..184; 186..192; 203..212; 219..229; 237..239; 241..248; 253..259; 273..277; 289..291; 297..300; 310..324; 328..337; 345..349; 356..361; 367..374; 384..388; 393..399; 402..407; 417..431; 434..445
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
906..921; Basic and acidic residues; 1109..1123; Basic and acidic residues; 1130..1148; Basic and acidic residues
Domain (FT)
22..129; Cadherin 1; 130..238; Cadherin 2; 239..346; Cadherin 3; 350..453; Cadherin 4; 454..563; Cadherin 5; 569..672; Cadherin 6
Region
901..921; Disordered; 1100..1148; Disordered
Clinical Relevance
Disease Involvement (3)
Disease variantEpilepsyIntellectual disability
Related Diseases (2)
Antibody
Supporting Publications2
| PMID | Title | Related sentences |
|---|---|---|
| 30865381 | Surfaceome of Exosomes Secreted from the Colorectal Cancer Cell Line SW480: Peripheral and Integral Membrane Proteins Analyzed by Proteolysis and TX114. | No related sentences available |
| 32384937 | Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. | No related sentences available |