Protein detail

SUN3

SUN domain-containing protein 3 (Sad1/unc-84 domain-containing protein 1)

Entry name SUN3	UniProt ID Q8TAQ9	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification Predicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

SUN domain-containing protein 3 (Sad1/unc-84 domain-containing protein 1)

Protein Class (2)

Predicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins

Transmembrane

48..64; Helical

Transmembrane Count

Ensembl

ENSG00000164744

Entrez Gene Symbol

SUN3

Gene Synonym (2)

MGC33329SUNC1

Gene Description

Sad1 and UNC84 domain containing 3

Chromosome

Position

47987148-48029119

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Cell SpecificEpicardial cellsBlood Lineage Specificdendritic cells

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component (3)

Molecular Function

GO:0043495 protein-membrane adaptor activity

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence17

Ligand-Receptor Signaling (9)

9 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No

Protein Complex Composition (7)

7 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
LINC complex	KASH5 SPAG4 SUN1 SUN2 SUN3 SUN5 SYNE1 SYNE2 SYNE3 SYNE4	O94901 Q6ZMZ3 Q8N205 Q8N6L0 Q8NF91 Q8TAQ9 Q8TC36 Q8WXH0 Q9NPE6 Q9UH99	0:0:0:0:0:0:0:0:0:0	SIGNOR	SIGNOR:SIGNOR-C303
SUN-KASH complex	SUN1 SUN2 SUN3 SYNE1 SYNE2 SYNE3	O94901 Q6ZMZ3 Q8NF91 Q8TAQ9 Q8WXH0 Q9UH99	1:1:1:1:1:1	Compleat	Compleat:HC1726	18396275
	CEBPZ DDX27 FBLL1 NAA20 NAA25 NIP7 NSUN3 PUM3 RBM28 RPL3L RRP1B RSL1D1 UBC URB1	A6NHQ2 O60287 O76021 P0CG48 P61599 Q03701 Q14684 Q14CX7 Q15397 Q92901 Q96GQ7 Q9H649 Q9NW13 Q9Y221	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5111
	CSNK2A1 DDX18 DDX27 GNL3 MDN1 NOP56 NSUN3 PUM3 RBM28 RPL5 RRP1B RSL1D1 SLIRP UBC URB1	O00567 O60287 O76021 P0CG48 P46777 P68400 Q14684 Q15397 Q96GQ7 Q9BVP2 Q9GZT3 Q9H649 Q9NU22 Q9NVP1 Q9NW13	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4746
	DDX27 NIP7 NSUN3 NVL PUM3 RBM28 RPL5 RRP1B RSL1D1 TTF2 UBC WDR37 WDR74	O15381 O76021 P0CG48 P46777 Q14684 Q15397 Q6RFH5 Q96GQ7 Q9H649 Q9NW13 Q9UNY4 Q9Y221 Q9Y2I8	1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8932
	CEBPZ DDX27 DDX31 EBNA1BP2 NIP7 NSUN3 RBM28 RPL5 RRP1B RSL1D1 UBC URB1 WDR74	O60287 O76021 P0CG48 P46777 Q03701 Q14684 Q6RFH5 Q96GQ7 Q99848 Q9H649 Q9H8H2 Q9NW13 Q9Y221	1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6897
	DDX27 EIF6 GTPBP4 MRTO4 NIP7 NOC3L NSUN3 PA2G4 PUM3 RPL3 UBC WDR37 WDR74	P0CG48 P39023 P56537 Q15397 Q6RFH5 Q8WTT2 Q96GQ7 Q9BZE4 Q9H649 Q9UKD2 Q9UQ80 Q9Y221 Q9Y2I8	1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6810

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry；Western blotting；Immunoelectron Microscopy；RNA Sequencing；Flow cytometry	2	40985879 38207106

Sequence, Structure & Domains8

Sequences

Length

357

Mass

40,503

Sequence

MSGKTKARRAAMFFRRCSEDASGSASGNALLSEDENPDANGVTRSWKIILSTMLTLTFLLVGLLNHQWLKETDVPQKSRQLYAIIAEYGSRLYKYQARLRMPKEQLELLKKESQNLENNFRQILFLIEQIDVLKALLRDMKDGMDNNHNWNTHGDPVEDPDHTEEVSNLVNYVLKKLREDQVEMADYALKSAGASIIEAGTSESYKNNKAKLYWHGIGFLNHEMPPDIILQPDVYPGKCWAFPGSQGHTLIKLATKIIPTAVTMEHISEKVSPSGNISSAPKEFSVYGITKKCEGEEIFLGQFIYNKTGTTVQTFELQHAVSEYLLCVKLNIFSNWGHPKYTCLYRFRVHGTPGKHI

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8TAQ9-1; Sequence=Displayed; Name=2; IsoId=Q8TAQ9-2; Sequence=VSP_029748, VSP_029749; Name=3; IsoId=Q8TAQ9-3; Sequence=VSP_055624

Alternative Sequence

1..100; Missing (in isoform 2); 2..61; SGKTKARRAAMFFRRCSEDASGSASGNALLSEDENPDANGVTRSWKIILSTMLTLTFLLV -> EDYSKYNAYTDFSSCRLECSGAILAHCNLHLLGSSISPASASRVAGTT (in isoform 3); 287; Y -> YVQRYMCRFVIQA (in isoform 2)

Domain & Motif Annotations

Coiled Coil

98..146

Domain (CC)

The short coiled coil domain is proposed to be not involved in load-bearing and force transmission from the cytoskeleton but in mere nucleus anchorage instead.

Domain (FT)

193..354; SUN

Clinical Relevance1

Antibody

HPA076890

Supporting Publications1

PMID	Title	Abstract
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No abstract available