Protein detail

S35G2

Solute carrier family 35 member G2 (Transmembrane protein 22)

Entry name S35G2	UniProt ID Q8TBE7	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 10	Protein classification Predicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Solute carrier family 35 member G2 (Transmembrane protein 22)

Protein Class (2)

Predicted membrane proteinsTransporters

Protein Function

Transporters:Electrochemical Potential-driven transporters

Transmembrane

105..125; Helical; Name=1; 131..151; Helical; Name=2; 169..189; Helical; Name=3; 194..214; Helical; Name=4; 218..238; Helical; Name=5; 255..275; Helical; Name=6; 286..306; Helical; Name=7; 319..339; Helical; Name=8; 346..366; Helical; Name=9; 368..388; Helical; Name=10

Transmembrane Count

Ensembl

ENSG00000168917

Entrez Gene Symbol

SLC35G2

Gene Synonym (3)

DKFZp564K2464MGC3295TMEM22

Gene Description

Solute carrier family 35 member G2

Chromosome

Position

136818647-136855888

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Cell SpecificCone photoreceptor cellsBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cells

Function & Pathway5

Protein Function

Transporters:Electrochemical Potential-driven transporters

Cellular Component (3)

Molecular Function

GO:0005515 protein binding

Biological Process (3)

Mediation Categories

Fusion and delivery mediation

Relations & Evidence20

Ligand-Receptor Signaling (17)

17 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
solute_carrier	transporter	Almen2009	No	Yes	No	No	No
transporter	transporter	OmniPath	No	Yes	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No

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Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	EVPLL HTR2C SLC35G2	A8MZ36 P28335 Q8TBE7	0:0:0	hu.MAP2
	LRRC36 SLC35G2 ZNF548	Q1X8D7 Q8NEK5 Q8TBE7	0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry；Western blotting；ELISA；Immunoelectron Microscopy；Flow cytometry	2	39558134 33709510

Sequence, Structure & Domains6

Sequences

Length

412

Mass

46,422

Sequence

MDTSPSRKYPVKKRVKIHPNTVMVKYTSHYPQPGDDGYEEINEGYGNFMEENPKKGLLSEMKKKGRAFFGTMDTLPPPTEDPMINEIGQFQSFAEKNIFQSRKMWIVLFGSALAHGCVALITRLVSDRSKVPSLELIFIRSVFQVLSVLVVCYYQEAPFGPSGYRLRLFFYGVCNVISITCAYTSFSIVPPSNGTTMWRATTTVFSAILAFLLVDEKMAYVDMATVVCSILGVCLVMIPNIVDEDNSLLNAWKEAFGYTMTVMAGLTTALSMIVYRSIKEKISMWTALFTFGWTGTIWGISTMFILQEPIIPLDGETWSYLIAICVCSTAAFLGVYYALDKFHPALVSTVQHLEIVVAMVLQLLVLHIFPSIYDVFGGVIIMISVFVLAGYKLYWRNLRKQDYQEILDSPIK

Domain & Motif Annotations

Domain (FT)

119..237; EamA 1; 268..388; EamA 2

Protein Families

SLC35G solute transporter family

Sequence Similarities

Belongs to the SLC35G solute transporter family.

Clinical Relevance1

Antibody (2)

HPA052054 HPA064728

Supporting Publications1

PMID	Title	Abstract
32384937	Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles.	No abstract available