Protein detail

TM254

Transmembrane protein 254

Entry name TM254	UniProt ID Q8TBM7	EVMP confidence score 0.50
Supporting publications (n) 3	Transmembrane count 3	Protein classification Predicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information12

Protein Names

Transmembrane protein 254

Protein Class

Predicted membrane proteins

Transmembrane

15..35; Helical; 61..81; Helical; 95..115; Helical

Transmembrane Count

Ensembl

ENSG00000133678

Entrez Gene Symbol

TMEM254

Gene Synonym (3)

bA369J21.6C10orf57FLJ13263

Gene Description

Transmembrane protein 254

Chromosome

Position

80078646-80092557

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization2

Cell SpecificEpididymal basal cellsSingle-Nuclei Brain Specificependymal cell

Function & Pathway4

Cellular Component

GO:0016020 membrane

Molecular Function

GO:0005515 protein binding

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence9

Ligand-Receptor Signaling (8)

8 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	4	40985879 38207106 30915084 31805958

Sequence, Structure & Domains5

Sequences

Length

123

Mass

14,243

Sequence

MATAAGATYFQRGSLFWFTVITLSFGYYTWVVFWPQSIPYQNLGPLGPFTQYLVDHHHTLLCNGYWLAWLIHVGESLYAIVLCKHKGITSGRAQLLWFLQTFFFGIASLTILIAYKRKRQKQT

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8TBM7-1; Sequence=Displayed; Name=2; IsoId=Q8TBM7-2; Sequence=VSP_047062; Name=3; IsoId=Q8TBM7-3; Sequence=VSP_047063

Alternative Sequence

85..123; Missing (in isoform 2); 85..123; HKGITSGRAQLLWFLQTFFFGIASLTILIAYKRKRQKQT -> QNELRIRIKMRKLILRDSE (in isoform 3)

Clinical Relevance1

Antibody (2)

HPA029105 HPA072613

Supporting Publications3

PMID	Title	Abstract
29603567	Involvement of serum-derived exosomes of elderly patients with bone loss in failure of bone remodeling via alteration of exosomal bone-related proteins.	No abstract available
32384937	Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles.	No abstract available
36028467	Plasma exosomal DOK3 reflects immunological states in lung tumor and predicts prognosis of gefitinib treatment.	No abstract available