Protein detail
BICD2
Protein bicaudal D homolog 2 (Bic-D 2)
Protein symbol BICD2 | UniProt ID | EVMP score 0.50 |
Frequency 6 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins |
Basic Information
Protein Names
Protein bicaudal D homolog 2 (Bic-D 2)
Protein Class
Disease related genesHuman disease related genesPredicted intracellular proteins
Protein Function
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Disease related genes
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
KIAA0699
Gene Description
BICD cargo adaptor 2
Chromosome
9
Position
92711363-92764833
Frequency
6
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificCytotrophoblasts
Function & Pathway
Protein Function
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Disease related genes
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| BICD2 | GSK3B | P49841 | S | 582 | phosphorylation | KEA | KEA:17570479 |
| BICD2 | MAPK9 | P45984 | S | 582 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| RBP2 | P49792 | BICD2 | Q8TD16 | Yes | Yes | No | SIGNOR | SIGNOR:20386726 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 31805958 |
Sequence, Structure & Domains
Sequences
Length
824
Mass
93,533
Sequence
MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQTRRGRAKAAPKTKPATPSL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8TD16-1; Sequence=Displayed; Name=2; IsoId=Q8TD16-2; Sequence=VSP_007969
Alternative Sequence
824; L -> VSHTCACASDRAEGTGLANQVFCSEKHSIYCD (in isoform 2)
3D Structural Models
Helix
6..16; 19..78; 715..740; 743..799
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
402..422; Basic and acidic residues; 604..618; Low complexity
Coiled Coil
20..269; 338..537; 666..808
Domain (CC)
The fourth coiled coil region is involved in Golgi targeting and in the interaction with DCTN2..
Region
25..398; Interacts with DYNLL1, DYNC1H1, DYNC1I2, DCTN1 and DCTN2; 311..330; Disordered; 334..599; Interaction with KIF5A; 398..425; Disordered; 559..622; Disordered; 590..824; Interaction with RANBP2; 666..814; Interacts with RAB6A; 804..824; Disordered
Protein Families
BicD family
Sequence Similarities
Belongs to the BicD family.