Protein detail
MO2R1
Cell surface glycoprotein CD200 receptor 1 (CD200 cell surface glycoprotein receptor) (Cell surface glycoprotein OX2 receptor 1)
Entry name MO2R1 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Cell surface glycoprotein CD200 receptor 1 (CD200 cell surface glycoprotein receptor) (Cell surface glycoprotein OX2 receptor 1)
Protein Function
Predicted intracellular proteins
Transmembrane
266..286; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Supporting publications (n)
1
EVMP confidence score
0.53
Fluorescence & Localization
Tissue SpecificbrainCell SpecificAstrocytesBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (5)
Molecular Function (4)
Biological Process (3)
Reactome (2)
Canonical Pathways (3)
- M184 Pid ecadherin keratinocyte pathway
- M72 Pid nectin pathway
- M266 Pid ncadherin pathway
Mediation Categories (2)
Fusion and delivery mediationImmune mediation
Relations & Evidence46
Ligand-Receptor Signaling (45)
45 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | OmniPath | Yes | Yes | |||
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | Yes | Yes | |||
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | Yes | Yes | |||
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | Yes | Yes | |||
| secreted | secreted | UniProt_keyword | Yes | Yes | |||
| secreted | secreted | UniProt_location | Yes | Yes | |||
| secreted | secreted | OmniPath | Yes | Yes | |||
| cell_surface | cell_surface | Surfaceome | Yes | Yes | |||
| cell_surface | cell_surface | connectomeDB2020 | Yes | Yes | |||
| cell_surface | cell_surface | OmniPath | Yes | Yes |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyPolymer PrecipitationImmunoaffinity Capture | Mass spectrometry | 15 | 268265363811336840465195353599233649718434064677401894973285431540985879375638574130796836146834318059583820710639207047 |
Sequence, Structure & Domains
Sequences
Length
348
Mass
39,041
Sequence
MLCPWRTANLGLLLILTIFLVAEAEGAAQPNNSLMLQTSKENHALASSSLCMDEKQITQNYSKVLAEVNTSWPVKMATNAVLCCPPIALRNLIIITWEIILRGQPSCTKAYKKETNETKETNCTDERITWVSRPDQNSDLQIRTVAITHDGYYRCIMVTPDGNFHRGYHLQVLVTPEVTLFQNRNRTAVCKAVAGKPAAHISWIPEGDCATKQEYWSNGTVTVKSTCHWEVHNVSTVTCHVSHLTGNKSLYIELLPVPGAKKSAKLYIPYIILTIIILTIVGFIWLLKVNGCRKYKLNKTESTPVVEEDEMQPYASYTEKNNPLYDTTNKVKASEALQSEVDTDLHTL
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=4; IsoId=Q8TD46-4; Sequence=Displayed; Name=1; IsoId=Q8TD46-1; Sequence=VSP_061888; Name=2; IsoId=Q8TD46-2; Sequence=VSP_061889, VSP_061890; Name=3; IsoId=Q8TD46-3; Sequence=VSP_061888, VSP_061889, VSP_061890
Alternative Sequence
22..45; AEAEGAAQPNNSLMLQTSKENHAL -> A (in isoform 1 and isoform 3); 174..188; VTPEVTLFQNRNRTA -> GKEHHILRYFTSPDL (in isoform 2 and isoform 3); 189..348; Missing (in isoform 2 and isoform 3)
3D Structural Models
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Domain (FT)
160..251; Ig-like C2-type
Protein Families
CD200R family
Sequence Similarities
Belongs to the CD200R family.
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 37862381 | Surfaceome analysis of extracellular vesicles from senescent cells uncovers uptake repressor DPP4. | Surfaceome analysis of extracellular vesicles from senescent cells uncovers uptake repressor DPP4. |