Protein detail

PKHO2

Pleckstrin homology domain-containing family O member 2 (PH domain-containing family O member 2) (Pleckstrin homology domain-containing family Q member 1) (PH domain-containing family Q member 1)

Entry name PKHO2	UniProt ID Q8TD55	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Pleckstrin homology domain-containing family O member 2 (PH domain-containing family O member 2) (Pleckstrin homology domain-containing family Q member 1) (PH domain-containing family Q member 1)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000241839

Entrez Gene Symbol

PLEKHO2

Gene Synonym (4)

DKFZp761K2312PLEKHQ1PP1628pp9099

Gene Description

Pleckstrin homology domain containing O2

Chromosome

Position

64841883-64868002

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization2

Tissue Specificskeletal muscleCell SpecificMyonuclei

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (2)

Molecular Function

GO:0005515 protein binding

Biological Process (3)

Reactome (2)

Mediation Categories

Immune mediation

Relations & Evidence9

Ligand-Receptor Signaling (5)

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm	ecm	MatrixDB	Yes	No	No	No	No
ecm	ecm	OmniPath	Yes	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (3)

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database
ARX CRISP2 MAP3K6 PLEKHO2 TACC3	O95382 P16562 Q8TD55 Q96QS3 Q9Y6A5	0:0:0:0:0	hu.MAP2
CAPZA1 CAPZB PLEKHO2	P47756 P52907 Q8TD55	0:0:0	hu.MAP2
PLEKHO2 TACC3	Q8TD55 Q9Y6A5	0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyMicrofluidics-Based Methods	Mass spectrometry	11	33718342 40545963 32795414 40784529 38490958 38576002 30760538 41216884 40311616 40091455 30451371

Sequence, Structure & Domains9

Sequences

Length

490

Mass

53,350

Sequence

MEEEGVKEAGEKPRGAQMVDKAGWIKKSSGGLLGFWKDRYLLLCQAQLLVYENEDDQKCVETVELGSYEKCQDLRALLKRKHRFILLRSPGNKVSDIKFQAPTGEEKESWIKALNEGINRGKNKAFDEVKVDKSCALEHVTRDRVRGGQRRRPPTRVHLKEVASAASDGLLRLDLDVPDSGPPVFAPSNHVSEAQPRETPRPLMPPTKPFLAPETTSPGDRVETPVGERAPTPVSASSEVSPESQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETSEAAPREGGKPPTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPSQAEGTPGTPPKDATTSTALPPWDLPPQFHPRCSSLGDLLGEGPRHPLQPRERLYRAQLEVKVASEQTEKLLNKVLGSEPAPVSAETLLSQAVEQLRQATQVLQEMRDLGELSQEAPGLREKRKELVTLYRRSAP

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8TD55-1; Sequence=Displayed; Name=2; IsoId=Q8TD55-2; Sequence=VSP_029212

Alternative Sequence

4..53; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

230..243; Low complexity; 244..257; Acidic residues; 277..297; Low complexity

Coiled Coil

439..481

Domain (FT)

18..119; PH

Region

173..402; Disordered

Clinical Relevance4

Antibody

HPA040055

Interaction Protein

ENSG00000077549

Interaction Count

Interaction Dataset

biogrid_opencell

Supporting Publications1

PMID	Title	Abstract
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available