Protein detail
GTR14
Solute carrier family 2, facilitated glucose transporter member 14 (Glucose transporter type 14) (GLUT-14)
Protein symbol GTR14 | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count 12 | Protein classification Metabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Solute carrier family 2, facilitated glucose transporter member 14 (Glucose transporter type 14) (GLUT-14)
Protein Class
Metabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Transporters:Electrochemical Potential-driven transporters
- Predicted intracellular proteins
Transmembrane
30..50; Helical; Name=1; 89..109; Helical; Name=2; 118..138; Helical; Name=3; 149..169; Helical; Name=4; 178..198; Helical; Name=5; 208..228; Helical; Name=6; 294..314; Helical; Name=7; 329..349; Helical; Name=8; 359..379; Helical; Name=9; 393..413; Helical; Name=10; 424..444; Helical; Name=11; 452..472; Helical; Name=12
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym
GLUT14SLC2A3P3
Gene Description
Solute carrier family 2 member 14
Chromosome
12
Position
7812512-7891148
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificadipose tissueCell SpecificNeutrophilsSingle-Nuclei Brain SpecificleukocyteBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
- Transporters:Electrochemical Potential-driven transporters
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
22 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | No | No |
| cell_surface | cell_surface | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation；Acoustic trapping | Mass spectrometry | 1 | 27487081 |
Sequence, Structure & Domains
Sequences
Length
520
Mass
56,320
Sequence
MEFHNGGHVSGIGGFLVSLTSRMKPHTLAVTPALIFAITVATIGSFQFGYNTGVINAPETIIKEFINKTLTDKANAPPSEVLLTNLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAATGGCLMGLCKIAESVEMLILGRLVIGLFCGLCTGFVPMYIGEISPTALRGAFGTLNQLGIVIGILVAQIFGLELILGSEELWPVLLGFTILPAILQSAALPCCPESPRFLLINRKKEENATRILQRLWGTQDVSQDIQEMKDESARMSQEKQVTVLELFRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAGVQQPIYATISAGVVNTIFTLLSLFLVERAGRRTLHMIGLGGMAFCSTLMTVSLLLKNHYNGMSFVCIGAILVFVACFEIGPGPIPWFIVAELFSQGPRPAAMAVAGCSNWTSNFLVGLLFPSAAYYLGAYVFIIFTGFLITFLAFTFFKVPETRGRTFEDITRAFEGQAHGADRSGKDGVMGMNSIEPAKETTTNV
Alternative Products
Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=GLUT14-L; IsoId=Q8TDB8-1; Sequence=Displayed; Name=2; Synonyms=GLUT14-S; IsoId=Q8TDB8-2; Sequence=VSP_014450; Name=3; IsoId=Q8TDB8-3; Sequence=VSP_014449; Name=4; IsoId=Q8TDB8-4; Sequence=VSP_055253; Name=5; IsoId=Q8TDB8-5; Sequence=VSP_055254
Alternative Sequence
1..359; Missing (in isoform 3); 1..113; MEFHNGGHVSGIGGFLVSLTSRMKPHTLAVTPALIFAITVATIGSFQFGYNTGVINAPETIIKEFINKTLTDKANAPPSEVLLTNLWSLSVAIFSVGGMIGSFSVGLFVNRFG -> MLLR (in isoform 4); 1..29; MEFHNGGHVSGIGGFLVSLTSRMKPHTLA -> MDNRQN (in isoform 2); 1..29; MEFHNGGHVSGIGGFLVSLTSRMKPHTLA -> MQRLQLLRVEVLLGVKQGDEMRHFFFSSQTSTLEKSQNGGVGEE (in isoform 5)
3D Structural Models
Domain & Motif Annotations
Region
493..520; Disordered
Protein Families
- Major facilitator superfamily
- Sugar transporter (TC 2.A.1.1) family
- Glucose transporter subfamily
Sequence Similarities
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Clinical Relevance
Antibody