Protein detail
GRP4
RAS guanyl-releasing protein 4
Entry name GRP4 | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 3 | Transmembrane count | Protein classification |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
RAS guanyl-releasing protein 4
Protein Function (2)
- Predicted intracellular proteins
- RAS pathway related proteins
Ensembl
Entrez Gene Symbol
Supporting publications (n)
3
EVMP confidence score
0.40
Function & Pathway
Protein Function (2)
- Predicted intracellular proteins
- RAS pathway related proteins
Cellular Component (5)
Molecular Function (4)
Biological Process (3)
KEGG (3)
Reactome (5)
Canonical Pathways
M11736 Sa mmp cytokine connection
Mediation Categories (2)
Immune mediationReceptor-signaling mediation
Relations & Evidence11
Ligand-Receptor Signaling (9)
9 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | |||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| transmembrane | transmembrane | Ramilowski_location | |||||
| transmembrane | transmembrane | OmniPath | |||||
| plasma_membrane | plasma_membrane | UniProt_location | |||||
| plasma_membrane | plasma_membrane | OmniPath |
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass spectrometryR Sequencing | 1 | 38343172 |
Sequence, Structure & Domains
Sequences
Length
673
Mass
74,882
Sequence
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS
Alternative Products
Event=Alternative splicing; Named isoforms=8; Name=1; IsoId=Q8TDF6-1; Sequence=Displayed; Name=2; Synonyms=variant 2; IsoId=Q8TDF6-2; Sequence=VSP_030480; Name=3; Synonyms=variant 1; IsoId=Q8TDF6-3; Sequence=VSP_030479; Name=4; IsoId=Q8TDF6-5; Sequence=VSP_043138; Name=5; IsoId=Q8TDF6-6; Sequence=VSP_043176; Name=6; IsoId=Q8TDF6-7; Sequence=VSP_043392; Name=7; IsoId=Q8TDF6-8; Sequence=VSP_046907; Name=8; IsoId=Q8TDF6-9; Sequence=VSP_046908
Alternative Sequence
171..673; Missing (in isoform 3); 171..184; Missing (in isoform 2); 221..409; Missing (in isoform 5); 222..318; Missing (in isoform 6); 222..255; Missing (in isoform 7); 319..410; Missing (in isoform 4); 319..387; Missing (in isoform 8)
3D Structural Models
Turn
133..136; 162..167
Helix
62..66; 80..92; 95..106; 115..131; 140..156; 202..218; 222..231; 238..259; 264..283; 287..298; 300..303; 306..311; 314..326; 330..342; 353..364; 376..394; 403..413; 419..429
Beta Strand
261..263; 372..374
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
1..10; Basic residues; 20..30; Basic residues
Zinc Finger
540..590; Phorbol-ester/DAG-type
Domain (CC)
The phorbol-ester/DAG-type zinc finger mediates the binding and the functional activation by DAG.
Domain (FT)
49..175; N-terminal Ras-GEF; 201..432; Ras-GEF; 466..501; EF-hand
Region
1..30; Disordered; 160..187; Disordered; 593..621; Disordered; 639..673; Disordered
Protein Families
RASGRP family
Sequence Similarities
Belongs to the RASGRP family.
Supporting Publications3
| PMID | Title | Related sentences |
|---|---|---|
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No related sentences available |
| 40619995 | A 96-Well Ultrafiltration Approach for the High-Throughput Proteome Analysis of Extracellular Vesicles Isolated From Conditioned Medium. | No related sentences available |
| 40784529 | Serum-derived exosome proteomics unveils the distinct and adjustable nature of the dampness constitution in traditional Chinese medicine. | No related sentences available |