Protein detail
GRP4
RAS guanyl-releasing protein 4
Entry name GRP4 | UniProt ID | EVMP score 0.38 |
Frequency 3 | Transmembrane count | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
RAS guanyl-releasing protein 4
Protein Function
- Predicted intracellular proteins
- RAS pathway related proteins
Ensembl
Entrez Gene Symbol
Frequency
3
EVMP Score
0.38
Fluorescence & Localization
Function & Pathway
Protein Function
- Predicted intracellular proteins
- RAS pathway related proteins
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Canonical Pathways
M11736 Sa mmp cytokine connection
Mediation Categories
Immune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
9 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass spectrometryR Sequencing | 1 | 38343172 |
Sequence, Structure & Domains
Sequences
Length
673
Mass
74,882
Sequence
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS
Alternative Products
Event=Alternative splicing; Named isoforms=8; Name=1; IsoId=Q8TDF6-1; Sequence=Displayed; Name=2; Synonyms=variant 2; IsoId=Q8TDF6-2; Sequence=VSP_030480; Name=3; Synonyms=variant 1; IsoId=Q8TDF6-3; Sequence=VSP_030479; Name=4; IsoId=Q8TDF6-5; Sequence=VSP_043138; Name=5; IsoId=Q8TDF6-6; Sequence=VSP_043176; Name=6; IsoId=Q8TDF6-7; Sequence=VSP_043392; Name=7; IsoId=Q8TDF6-8; Sequence=VSP_046907; Name=8; IsoId=Q8TDF6-9; Sequence=VSP_046908
Alternative Sequence
171..673; Missing (in isoform 3); 171..184; Missing (in isoform 2); 221..409; Missing (in isoform 5); 222..318; Missing (in isoform 6); 222..255; Missing (in isoform 7); 319..410; Missing (in isoform 4); 319..387; Missing (in isoform 8)
3D Structural Models
Turn
133..136; 162..167
Helix
62..66; 80..92; 95..106; 115..131; 140..156; 202..218; 222..231; 238..259; 264..283; 287..298; 300..303; 306..311; 314..326; 330..342; 353..364; 376..394; 403..413; 419..429
Beta Strand
261..263; 372..374
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
1..10; Basic residues; 20..30; Basic residues
Zinc Finger
540..590; Phorbol-ester/DAG-type
Domain (CC)
The phorbol-ester/DAG-type zinc finger mediates the binding and the functional activation by DAG.
Domain (FT)
49..175; N-terminal Ras-GEF; 201..432; Ras-GEF; 466..501; EF-hand
Region
1..30; Disordered; 160..187; Disordered; 593..621; Disordered; 639..673; Disordered
Protein Families
RASGRP family
Sequence Similarities
Belongs to the RASGRP family.