Protein detail

IGDC4

Immunoglobulin superfamily DCC subclass member 4 (Neighbor of punc e11) (Protein DDM36) (hDDM36)

Protein symbol IGDC4	UniProt ID Q8TDY8	EVMP score 0.25
Frequency 5	Transmembrane count 1	Protein classification Plasma proteinsPredicted membrane proteins

Basic Information

Protein Names

Immunoglobulin superfamily DCC subclass member 4 (Neighbor of punc e11) (Protein DDM36) (hDDM36)

Protein Class

Plasma proteinsPredicted membrane proteins

Transmembrane

958..978; Helical

Transmembrane Count

Ensembl

ENSG00000103742

Entrez Gene Symbol

IGDCC4

Gene Synonym

LOC57722NOPE

Gene Description

Immunoglobulin superfamily DCC subclass member 4

Chromosome

Position

65381484-65422947

Frequency

EVMP Score

0.25

Fluorescence & Localization

Cell SpecificNeutrophils

Function & Pathway

Cellular Component

GO:0005886 plasma membrane

Biological Process

Canonical Pathways

M5880 Naba ecm affiliated
M5885 Naba matrisome associated
M5889 Naba matrisome

Mediation Categories

Other mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

37 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	Surfaceome	No	Yes	No	Yes	No
ig_like	receptor	Almen2009	No	Yes	No	Yes	No
netrin	receptor	Almen2009	No	Yes	No	Yes	No
ig	receptor	Surfaceome	No	Yes	No	Yes	No
netrinr	receptor	Surfaceome	No	Yes	No	Yes	No
growth_factor	receptor	ICELLNET	No	Yes	No	Yes	No
cell_adhesion	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
intracellular	intracellular	LOCATE	No	No	No	Yes	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometryWestern blotting	2	38225453 38731868

Sequence, Structure & Domains

Sequences

Length

1,250

Mass

134,210

Sequence

MARGDAGRGRGLLALTFCLLAARGELLLPQETTVELSCGVGPLQVILGPEQAAVLNCSLGAAAAGPPTRVTWSKDGDTLLEHDHLHLLPNGSLWLSQPLAPNGSDESVPEAVGVIEGNYSCLAHGPLGVLASQTAVVKLATLADFSLHPESQTVEENGTARFECHIEGLPAPIITWEKDQVTLPEEPRLIVLPNGVLQILDVQESDAGPYRCVATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGKPISTDVIVLGRTNLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVLAAPAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSAGMACAAASLAVVVREGLPSAPTRVTATPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQLSLSSPNPSDIRVAWLPLPPSLSNGQVVKYKIEYGLGKEDQIFSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRTPSMHNQSHVPFAPAELKVQAKMESLVVSWQPPPHPTQISGYKLYWREVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEKAPAPDMPIQRGPPLPPAHVHAESNSSTSIWLRWKKPDFTTVKIVNYTVRFSPWGLRNASLVTYYTSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPSTPPSDLRLSPLTPSTVRLHWCPPTEPNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSAEVHGLESDTRYFFKMGARTEVGPGPFSRLQDVITLQEKLSDSLDMHSVTGIIVGVCLGLLCLLACMCAGLRRSPHRESLPGLSSTATPGNPALYSRARLGPPSPPAAHELESLVHPHPQDWSPPPSDVEDRAEVHSLMGGGVSEGRSHSKRKISWAQPSGLSWAGSWAGCELPQAGPRPALTRALLPPAGTGQTLLLQALVYDAIKGNGRKKSPPACRNQVEAEVIVHSDFSASNGNPDLHLQDLEPEDPLPPEAPDLISGVGDPGQGAAWLDRELGGCELAAPGPDRLTCLPEAASASCSYPDLQPGEVLEETPGDSCQLKSPCPLGASPGLPRSPVSSSA

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8TDY8-1; Sequence=Displayed; Name=2; IsoId=Q8TDY8-2; Sequence=VSP_028046

Alternative Sequence

1..331; MARGDAGRGRGLLALTFCLLAARGELLLPQETTVELSCGVGPLQVILGPEQAAVLNCSLGAAAAGPPTRVTWSKDGDTLLEHDHLHLLPNGSLWLSQPLAPNGSDESVPEAVGVIEGNYSCLAHGPLGVLASQTAVVKLATLADFSLHPESQTVEENGTARFECHIEGLPAPIITWEKDQVTLPEEPRLIVLPNGVLQILDVQESDAGPYRCVATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGKPISTDVIVLGRTNLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRV -> MGRRKGRSALSRSSLERVNQGEVKVIGRGAREGGGGQAWGTGGGGRDLSCGIPRSASPLAP (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Domain (FT)

29..137; Ig-like C2-type 1; 143..229; Ig-like C2-type 2; 242..330; Ig-like C2-type 3; 335..421; Ig-like C2-type 4; 431..525; Fibronectin type-III 1; 527..623; Fibronectin type-III 2; 632..741; Fibronectin type-III 3; 752..845; Fibronectin type-III 4; 850..945; Fibronectin type-III 5

Region

1140..1175; Disordered; 1215..1250; Disordered

Protein Families

Immunoglobulin superfamily
DCC family

Sequence Similarities

Belongs to the immunoglobulin superfamily. DCC family.

Clinical Relevance

Antibody

HPA008510 HPA008576

Interaction Protein

ENSG00000196950

Interaction Count

Interaction Dataset

biogrid_bioplex