Protein detail
GPX8
Probable glutathione peroxidase 8 (GPx-8) (GSHPx-8) (EC 1.11.1.9)
Entry name GPX8 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification EnzymesMetabolic proteinsPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Probable glutathione peroxidase 8 (GPx-8) (GSHPx-8) (EC 1.11.1.9)
Protein Class (3)
EnzymesMetabolic proteinsPredicted intracellular proteins
Protein Function (3)
- Enzymes
- ENZYME proteins:Oxidoreductases
- Predicted intracellular proteins
Transmembrane
18..40; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
EPLA847UNQ847
Gene Description
Glutathione peroxidase 8 (putative)
Chromosome
5
Position
55160167-55167297
Supporting publications (n)
1
EVMP confidence score
0.53
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificNeutrophil progenitorsBlood Cell SpecificneutrophilBlood Lineage SpecificgranulocytesSecretome LocationIntracellular and membraneSecretome FunctionCell adhesion
Function & Pathway
Protein Function (3)
- Enzymes
- ENZYME proteins:Oxidoreductases
- Predicted intracellular proteins
Cellular Component (2)
Molecular Function (3)
Biological Process (3)
KEGG (6)
Reactome (3)
Mediation Categories
Clinical-translation mediation
Relations & Evidence16
Ligand-Receptor Signaling (13)
13 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane_phobius | transmembrane_predicted | Almen2009 | |||||
| transmembrane_sosui | transmembrane_predicted | Almen2009 | |||||
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 |
Page 2 of 2Previous
Protein Complex Composition (2)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 27863537 |
Sequence, Structure & Domains
Sequences
Length
209
Mass
23,881
Sequence
MEPLAAYPLKCSGPRAKVFAVLLSIVLCTVTLFLLQLKFLKPKINSFYAFEVKDAKGRTVSLEKYKGKVSLVVNVASDCQLTDRNYLGLKELHKEFGPSHFSVLAFPCNQFGESEPRPSKEVESFARKNYGVTFPIFHKIKILGSEGEPAFRFLVDSSKKEPRWNFWKYLVNPEGQVVKFWKPEEPIEVIRPDIAALVRQVIIKKKEDL
3D Structural Models
Turn
97..99
Helix
47..49; 62..65; 82..96; 119..130; 149..158; 187..189; 191..207
Beta Strand
51..54; 59..61; 68..75; 77..79; 100..107; 168..171; 177..181
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Protein Families
Glutathione peroxidase family
Sequence Similarities
Belongs to the glutathione peroxidase family.
Clinical Relevance
Drug Targets
Literature-reported target
Antibody
Interaction Protein (2)
ENSG00000168484ENSG00000168899
Interaction Count
2
Interaction Dataset (2)
intact_biogrid_bioplexintact_biogrid
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 22329422 | Quantitative proteome profiling of normal human circulating microparticles. | No related sentences available |