Protein detail
ARH40
Rho guanine nucleotide exchange factor 40 (Protein SOLO) (Scambio) (Sabi)
Entry name ARH40 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Rho guanine nucleotide exchange factor 40 (Protein SOLO) (Scambio) (Sabi)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
FLJ10357solo
Gene Description
Rho guanine nucleotide exchange factor 40
Chromosome
14
Position
21070273-21090248
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization1
Cell SpecificAdrenal cortex cells
Function & Pathway7
Protein Function
Predicted intracellular proteins
Cellular Component (4)
Molecular Function (2)
Biological Process (3)
Reactome (10)
- R-hsa-204998 cell death signalling via nrage nrif and nade
- R-hsa-73887 death receptor signaling
- R-hsa-416482 g alpha 12 13 signalling events
- R-hsa-193648 nrage signals death through jnk
- R-hsa-193704 p75 ntr receptor mediated signalling
- R-hsa-8980692 rhoa gtpase cycle
- R-hsa-9013106 rhoc gtpase cycle
- R-hsa-9012999 rho gtpase cycle
- R-hsa-372790 signaling by gpcr
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
Canonical Pathways (3)
- M5880 Naba ecm affiliated
- M5885 Naba matrisome associated
- M5889 Naba matrisome
Mediation Categories (2)
Immune mediationReceptor-signaling mediation
Relations & Evidence5
Ligand-Receptor Signaling (4)
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass spectrometryMORPH | 1 | 33799461 |
Sequence, Structure & Domains9
Sequences
Length
1,519
Mass
164,658
Sequence
MEPEPVEDCVQSTLAALYPPFEATAPTLLGQVFQVVERTYREDALRYTLDFLVPAKHLLAKVQQEACAQYSGFLFFHEGWPLCLHEQVVVQLAALPWQLLRPGDFYLQVVPSAAQAPRLALKCLAPGGGRVQEVPVPNEACAYLFTPEWLQGINKDRPTGRLSTCLLSAPSGIQRLPWAELICPRFVHKEGLMVGHQPSTLPPELPSGPPGLPSPPLPEEALGTRSPGDGHNAPVEGPEGEYVELLEVTLPVRGSPTDAEGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPRGQDGARPPGEGSSTGASPESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGGGGQGAEGPPGTPRRTGKGNRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALGNLPSPSEHKLPECHLVKEEYEGSGKPESEPKELKTAGEKEPQLSEACGPTEEGAGERELEGPGLLCMAGHTGPEGPLSDTPTPPLETVQEGKGDNIPEEALAVSVSDHPDVAWDLMASGFLILTGGVDQSGRALLTITPPCPPEEPPPSRDTLNTTLHYLHSLLRPDLQTLGLSVLLDLRQAPPLPPALIPALSQLQDSGDPPLVQRLLILIHDDLPTELCGFQGAEVLSENDLKRVAKPEELQWELGGHRDPSPSHWVEIHQEVVRLCRLCQGVLGSVRQAIEELEGAAEPEEEEAVGMPKPLQKVLADPRLTALQRDGGAILMRLRSTPSSKLEGQGPATLYQEVDEAIHQLVRLSNLHVQQQEQRQCLRRLQQVLQWLSGPGEEQLASFAMPGDTLSALQETELRFRAFSAEVQERLAQAREALALEENATSQKVLDIFEQRLEQVESGLHRALRLQRFFQQAHEWVDEGFARLAGAGPGREAVLAALALRRAPEPSAGTFQEMRALALDLGSPAALREWGRCQARCQELERRIQQHVGEEASPRGYRRRRADGASSGGAQWGPRSPSPSLSSLLLPSSPGPRPAPSHCSLAPCGEDYEEEGPELAPEAEGRPPRAVLIRGLEVTSTEVVDRTCSPREHVLLGRARGPDGPWGVGTPRMERKRSISAQQRLVSELIACEQDYVATLSEPVPPPGPELTPELRGTWAAALSARERLRSFHRTHFLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLENGLAALSPLSKGSMEAGPYLPRALQQPLEQLTRYGRLLEELLREAGPELSSECRALGAAVQLLREQEARGRDLLAVEAVRGCEIDLKEQGQLLHRDPFTVICGRKKCLRHVFLFEHLLLFSKLKGPEGGSEMFVYKQAFKTADMGLTENIGDSGLCFELWFRRRRAREAYTLQATSPEIKLKWTSSIAQLLWRQAAHNKELRVQQMVSMGIGNKPFLDIKALGERTLSALLTGRAARTRASVAVSSFEHAGPSLPGLSPGACSLPARVEEEAWDLDVKQISLAPETLDSSGDVSPGPRNSPSLQPPHPGSSTPTLASRGILGLSRQSHARALSDPTTPL
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8TER5-1; Sequence=Displayed; Name=2; IsoId=Q8TER5-2; Sequence=VSP_030381; Name=3; IsoId=Q8TER5-3; Sequence=VSP_030382; Name=4; IsoId=Q8TER5-4; Sequence=VSP_030383
Alternative Sequence
1..714; Missing (in isoform 2); 1415..1519; AARTRASVAVSSFEHAGPSLPGLSPGACSLPARVEEEAWDLDVKQISLAPETLDSSGDVSPGPRNSPSLQPPHPGSSTPTLASRGILGLSRQSHARALSDPTTPL -> GEGQGAGGWPPGVKTLTMRIQRGGMVESQERHLVPKSVGLAGRPSVRLRVIPGSQEGFPTPAPHPPLPTLCSRPHPGLRGRVIL (in isoform 3); 1415..1462; Missing (in isoform 4)
Domain & Motif Annotations
Compositional Bias
200..218; Pro residues; 280..290; Basic residues; 314..341; Low complexity; 355..367; Gly residues; 374..386; Basic residues; 421..457; Basic and acidic residues; 980..996; Low complexity; 1467..1482; Polar residues
Coiled Coil
828..871; 934..961
Domain (FT)
1085..1253; DH; 1265..1372; PH
Region
1..329; Interaction with KRT18; 14..52; Required for punctate localization on the ventral side of the cell and promotion of actin filament assembly and tensional force-induced actin stress fiber reinforcement; 194..237; Disordered; 253..503; Disordered; 330..1057; Interaction with ITGB4; 955..1031; Disordered; 1058..1427; Interaction with KRT18; 1076..1510; Interacts with RAC3; 1466..1519; Disordered
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 37466513 | Amelioration of exosome and mesenchymal stem cells in rats infected with diabetic nephropathy by attenuating early markers and aquaporin-1 expression. | Compared to the DN group, the co-administration of Balanites aegyptiacae with MSCs or exosomes substantially improved the undesirable elevated values of TNF-α and IGF-1. |